Longitudinal Changes in Insulin-Like Growth Factor-I, Insulin Sensitivity, and Secretion from Birth to Age Three Years in Small-for-Gestational-Age Children

Íñiguez, Germán; Ong, Ken K.; Bazaes, Rodrigo; Ávila, Alejandra; Salazar, Teresa; Dunger, David B.; Mericq, Verónica

doi:10.1210/jc.2006-0844

Cited by 103 publications

(59 citation statements)

References 32 publications

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“…In that study, a link was suggested between IUGR and polycystic ovary syndrome (PCOS), possibly caused by intrauterine programming affecting reproduction function in low-BW infant girls. Another explanation could be the positive relationship between insulin and AMH, as high-BW infants as well as low-BW infants who show catch-up growth are likely to have high insulin levels (33,34). Other recent studies showed no relation of BW with PCOS and AMH levels (30,35).…”

Section: Discussionmentioning

confidence: 98%

Influence of preterm birth and small birth size on serum anti-Müllerian hormone levels in young adult women

Kerkhof

Leunissen

Willemsen

et al. 2010

European Journal of Endocrinology

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Background/objectives: Preterm birth has been associated with reduced reproduction rates, and controversies remain regarding the effect of being born small for gestational age (SGA) on ovarian function. Recent findings in young men showed no effect of preterm and SGA birth on testis function. We hypothesised that follicle pool size in young adult women is also not affected by preterm and SGA birth. Design/methods: In 279 young women of the PROGRAM/PREMS study, aged 18-24 years, the influence of gestational age, birth length and birth weight on serum levels of anti-Mü llerian hormone (AMH) was analysed with multiple regression modelling. Additionally, AMH levels were analysed in preterm-versus term-born females and in three subgroups: females born SGA with either short stature or catch-up growth (SGA-CU), and females born term and appropriate for gestational age with normal stature (AGA controls). Results: Preterm and SGA birth did not affect AMH and other hormone levels. Older age at menarche and oral contraceptive pill use (OC-use) were related to lower AMH levels, and maternal smoking during gestation was related to higher AMH levels. After correction for maternal smoking, lower socioeconomic status (SES) was associated with lower AMH levels. In subgroup comparisons, SGA-CU women showed higher AMH levels than AGA controls, also after adjustment for several factors. Conclusion: Preterm and SGA birth did not affect AMH levels. Factors associated with serum AMH levels were OC-use, age at menarche, maternal smoking during gestation and SES. We conclude that preterm-and/or SGA-born females are not likely to have a reduced follicle pool size.

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Section: Discussionmentioning

confidence: 98%

Influence of preterm birth and small birth size on serum anti-Müllerian hormone levels in young adult women

Kerkhof

Leunissen

Willemsen

et al. 2010

European Journal of Endocrinology

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“…Serum IGF-I levels were determined by radioimmunoassay [22] . The sensitivity of this assay is 5.0 ng/ml, intra-assay CV is 8.6%, and the inter-assay CV is 10.2%.…”

Section: Methodsmentioning

confidence: 99%

Effects of Prenatal Ethanol Exposure on Postnatal Growth and the Insulin-Like Growth Factor Axis

et al. 2010

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“…Serum insulinlike growth factor 1 (IGF-1) was measured by radioimmunoassay by using a commercial kit (LincoResearch Inc, St Charles, MO) (sensitivity 5 ng/mL: intra-and interassay coefficients of variation: 8.6% and 10.2%, respectively). 17 In each of the visits, skeletal-maturation was assessed in duplicate by using an ultrasound-transmission method (BonAge; Sunlight Co, Medical, TelAviv, Israel). 18 …”

Section: Physical/sexual Maturationmentioning

confidence: 99%

Prepubertal Adiposity, Vitamin D Status, and Insulin Resistance

Cediel¹,

Romaña²,

Mericq

et al. 2016

Pediatrics

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OBJECTIVE: To evaluate the following from prepuberty to the puberty-onset: (1) changes in serum 25-hydroxyvitamin-D (25[OH]D), adiposity, and insulin resistance (IR); (2) the effect of prepubertal adiposity on serum 25(OH)D changes; and (3) the combined effect of prepubertal obesity and suboptimal-25(OH)D on IR at puberty-onset. METHODS:A total of 426 prepubertal children (∼54% girls) were followed during pubertalonset assessing before and after puberty-onset serum 25(OH)D, adiposity (BMI and waist circumference) and IR indicators (homeostasis-model-assessment of IR [HOMA-IR]). Associations were tested using multiple and logistic regression models adjusted by age, gender, and seasonality. CONCLUSIONS:We found that serum 25(OH)D declined with puberty-onset, likely because of adiposity increase. Moreover, children with the combined condition of central-obesity and suboptimal-25(OH)D before puberty-onset had higher pubertal IR. These results highlight the need of ensuring adequate-25(OH)D status before pubertal-onset, particularly in obese children.

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Longitudinal Changes in Insulin-Like Growth Factor-I, Insulin Sensitivity, and Secretion from Birth to Age Three Years in Small-for-Gestational-Age Children

Cited by 103 publications

References 32 publications

Influence of preterm birth and small birth size on serum anti-Müllerian hormone levels in young adult women

Influence of preterm birth and small birth size on serum anti-Müllerian hormone levels in young adult women

Effects of Prenatal Ethanol Exposure on Postnatal Growth and the Insulin-Like Growth Factor Axis

Prepubertal Adiposity, Vitamin D Status, and Insulin Resistance

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