Longitudinal Changes in Computerized EEG and Mental Function of the Aged: A Nine-Year Follow-Up Study

Nakano, Takashi; Miyasaka, Makoto; Ohtaka, Tadashi; Ohmori, Ken

doi:10.1017/s1041610292000875

Cited by 22 publications

(12 citation statements)

References 10 publications

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“…In contrast to the P300 amplitudes that remain relatively stable during aging, the P300 latency prolongations appear to be cor related with the slowing of the resting EEG [98], which occurs together with the cognitive decline in late senescence [99], For a direct analysis of the relationship between EEG and P300 potentials, however, EEG epochs pre ceding and following P300-eliciting events have to be investigated [100,101]. Data on this approach are rather sparse.…”

Section: Discussionmentioning

confidence: 99%

The Event-Related P300 Potential Analysis of Cognitive Human Brain Aging: A Review

1993

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Event-related P300 potentials are closely reflecting cognitive functions such as stimulus evaluation time (P300 latency) and task relevance (P300 amplitude). Hence, both their potential clinical application for detecting slight cognitive disturbances and an increasing interest in the aging of cognitive human brain functions resulted in a growing number of studies on age-related P300 changes. Although there are converging lines of evidence that aging results in prolongations of P300 latencies, reductions of P300 amplitudes and a more equipotential P300 scalp distribution, the amount of these changes and the best fit for the P300-age interactions, respectively, remain still controversial. In general, these P300 alterations obviously reflect only minor cognitive changes during normal aging. For their clinical application, however, it is necessary to obtain an age-matched normative database. Furthermore, the increased P300 variability in the elderly has to be reduced – as far as possible – by appropriate simple P300 paradigms which should be preferentially applied in longitudinal analyses to differentiate normal from pathological aging of cognitive functions. Finally, additional cross-correlational analyses between the P300 and morphological as well as neurobiochemical data are needed. By these means, our knowledge about age-related changes of cognitive brain functions should be considerably enlarged.

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Section: Discussionmentioning

confidence: 99%

The Event-Related P300 Potential Analysis of Cognitive Human Brain Aging: A Review

1993

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“…There have been relatively few longitudinal studies of healthy elderly adults (e.g., Coben, Danziger, & Storandt, 1985;Nakano, Miyasaka, Ohtaka, & Ohmori, 1992;Obrist, Henry, & Justiss, 1961;Shigeta et al, 1995), and the results have been consistent. For example, one study of 41 healthy elderly individuals (64.6-82.2 years at entry) reported an increase in delta wave activity and decreases in beta waves and mean frequency over a 2.5-year period; there was no significant change in theta or alpha activity (Coben et al, 1985).…”

mentioning

confidence: 87%

“…For example, one study of 41 healthy elderly individuals (64.6–82.2 years at entry) reported an increase in delta wave activity and decreases in beta waves and mean frequency over a 2.5-year period; there was no significant change in theta or alpha activity (Coben et al, 1985). On the other hand, a 9-year follow-up investigation of individuals in their late 70s by Nakano et al (1992) reported, along with a decline in cognitive function, a significant increase in beta and theta wave activities, with reciprocal decreases in slow alpha activity.…”

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confidence: 99%

EEG Frequency Characteristics in Healthy Advanced Elderly

Mizukami

Katada

2018

Journal of Psychophysiology

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Abstract. Changes in electroencephalographic (EEG) activity over the course of the normal aging process demonstrate that elderly individuals exhibit an increase in slow wave activity. In this study, we reexamined findings that EEG activity in healthy elderly individuals aged over 85 years (range 85–94) was the same or different compared to individuals younger than 84 years (range 65–84). We performed EEG frequency analysis to investigate the characteristics of resting state frequency components in a cross-sectional study. In individuals aged 85 and older, the dominant frequency component demonstrated a significant shift toward the slower alpha frequency in the left temporal and occipital regions. However, among the oldest individuals, a spectral peak appeared at 9.0–10.0 Hz, and power curves at peak frequency exhibited a sharp rise. Interestingly, healthy individuals older than 85 did not exhibit an appreciable change in EEG, suggesting that “slowing” is not a characteristic sign of aging.

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“…Matsuura et al (1995) reported a relationship between the amount of alpha waves and psychometric evaluations such as the Benton visual retention and Kohs blockdesign tests. In a study of longitudinal changes in computerized EEG using Hasegawa's dementia rating scale and the Bender-Gestalt test, Nakano et al (1992) reported that the EEG slowing, increased theta waves, and decreased alpha frequency were more obvious in subjects with mental deterioration.…”

Section: Introductionmentioning

confidence: 99%

Quantitative EEG Data and Comprehensive ADL (Activities of Daily Living) Evaluation of Stroke Survivors Residing in the Community.

Yuasa

Maeda

Higuchi

et al. 2001

J. Physiol. Anthropol.

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The purpose of this study was to investigate the hypothesis that EEG values match other comprehensive activities of daily living (ADL) evaluations between stroke survivors and normal controls. Various functions related to ADL were examined by means of ADL assessments (Measurement of Competence in the Elderly Living at Home, Barthel Index, Stroke Impairment Assessment Set, t i me n e e d e d to w a l k 10 me tr e s ) a n d bi o s o ci a l synchronization (the questionnaire on biosocial rhythms of daily living). EEG was undertaken using a computerassisted portable EEG recorder. The power spectra were computed using a fast Fourier transformation analysis (FFT). The absolute and relative powers (percent of the total EEG power) of 5 frequency bands (delta, theta, alpha 1, alpha 2 and beta) and the peak frequency were analyzed. In comparing stroke survivors and the independent elderly, the latter had higher scores than the former in assessments of various functions related to ADL. The absolute and relative power of the delta band were lower in normal controls, and the relative power of the alpha (2) band and the peak frequency were higher than those of stroke survivors. Among the correlations between EEG and ADL assessments, the absolute and r elati ve p ower of the alpha (2) band cor related significantly with ADL assessments of stroke survivors with right hemiplegia. The peak frequency was significantly increased in cases with high ADL scores. In conclusion, significant correlations were identified between the quantitative EEG data of stroke survivors in the chronic stage, living in the community, and ADLrelated functions. Computer-assisted portable EEG recording is a potentially useful screening tool for objectively evaluating the functional levels of stroke survivors in field work.

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Longitudinal Changes in Computerized EEG and Mental Function of the Aged: A Nine-Year Follow-Up Study

Cited by 22 publications

References 10 publications

The Event-Related P300 Potential Analysis of Cognitive Human Brain Aging: A Review

The Event-Related P300 Potential Analysis of Cognitive Human Brain Aging: A Review

EEG Frequency Characteristics in Healthy Advanced Elderly

Quantitative EEG Data and Comprehensive ADL (Activities of Daily Living) Evaluation of Stroke Survivors Residing in the Community.

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