Longitudinal changes in calcaneal quantitative ultrasound measures during childhood

Lee, M.; Nahhas, Ramzi W.; Choh, Audrey C.; Demerath, Ellen W.; Duren, Dana L.; Chumlea, William Cameron; Sherwood, Richard J.; Towne, Bradford; Siervogel, R. M.; Czerwinski, Stefan A.

doi:10.1007/s00198-010-1458-0

Cited by 14 publications

(6 citation statements)

References 67 publications

(107 reference statements)

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“…While BUA is a measure of how the ultrasound signal is absorbed or scattered by the bone and therefore reflects its porosity (density) without taking into account the surrounding soft tissue23. In healthy girls, BUA has been shown to increase with age2324 while data for AD-SOS is less consistent with one study showing an increase24, and another no change23. In our cohort of TS patients BMD did not alter with age, AD-SOS decreased and BUA increased.…”

Section: Discussioncontrasting

confidence: 50%

Body composition and bone mineral status in patients with Turner syndrome

Shi

Liu

et al. 2016

Sci Rep

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Turner syndrome (TS) is associated with decreased bone mineral density and increased fracture rate. However, the developmental trajectory of bone density or body composition in patients with TS is still unclear. The present study tested the hypothesis that different karyotypes and/or age contributes to abnormal body composition and decreased bone mineral status parameters in patients with TS. This study included 24 girls with TS, in which 13 girls exhibited X0 karyotype and 11 had mosaicism. Quantitative ultrasound (QUS) assessed the bone mineral status of the calcaneus, including bone mineral density (BMD), amplitude-dependent speed of sound (AD-SOS), broadband ultrasound attenuation (BUA) and InBody 770 assessed body composition. Pearson’s test was performed to correlate measured parameters with patient age. The body composition and bone mineral status parameters were not significantly influenced by patient karyotype. There was a correlation between patient age and AD-SOS (r = −0.61, P = 0.002) and BUA (r = 0.50, P = 0.013) but not BMD (r = −0.19, P = 0.379). In conclusion, there was no effect of karyotype on body composition or body mineral status. Bone mineral status, as evidenced by changes in AD-SOS and BUA, alters with age regardless of karyotype. The developmental trajectory demonstrated in the current study warrants further validation in a longitudinal study.

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Section: Discussioncontrasting

confidence: 50%

Body composition and bone mineral status in patients with Turner syndrome

Shi

Liu

et al. 2016

Sci Rep

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“…Age and BMI were good predictors of BUA and BQI values in our linear regression model. These results are consistent with some studies (8,9). A previous study reported that overweight prepubertal boys had better DEXA bone parameters than that of boys with normal nutritional status (24).…”

Section: Anthropometry and Qussupporting

confidence: 92%

“…The beneficial effects of exercise on skeletal health is evident (5)(6)(7). Bone parameters are also associated with age, several anthropometric variables and body fat percentage (8,9). Some previous studies have focused on the relationship between calcium and vitamin D intake and bone properties, and the effect of calcium supplementation on bone health during the prepubertal years (2,9).…”

Section: Introductionmentioning

confidence: 99%

Relationship between physical activity, dietary intake and bone parameters in 10-12 years old Hungarian boys and girls

Szmodis

Bosnyák

Protzner

et al. 2019

Cent Eur J Public Health

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Objectives: Physical activity (PA) and adequate macro-and micronutrient intake have favourable influence on the bone status. The aim of this study was to analyse the relationships among PA, anthropometric data, dietary intake and ultrasound bone characteristics in children.Methods: 10-12 years old Hungarian children (N = 123, 59 girls, 64 boys) provided physical activity, diet, anthropometric and bone data. PA was measured with accelerometer (Actigraph GT3X+). Diet was evaluated with three-day, 24-hour food recall. Calcaneal quantitative ultrasound (QUS) bone parameters were registered with Sonost3000 bone densitometer.Results: Nutrition and anthropometry did not differ by gender. The values of broadband ultrasound attenuation (BUA) were significantly higher in boys. Girls spent significantly more time being sedentary, boys had greater light, moderate, vigorous, and moderate to vigorous physical activity (MVPA) levels. The children accumulated more than twice the suggested amount of public health guidelines for MVPA. QUS parameters correlated significantly with vigorous physical activity in boys, and with age, height, weight, fat percentage, and body mass index (BMI) for both genders. There was no significant relationship between nutrition and QUS; however, inadequate vitamin K intake correlated with less favourable bone parameters. Multiple linear regression analysis confirmed the importance of vigorous PA -speed of sound (SOS): β = 0.358, p = 0.006; BUA: β = 0.340, p = 0.007; bone quality index (BQI): β = 0.377, p = 0.002; vitamin K intake -SOS: β = 0.256, p = 0.025; BUA: β = 0.235, p = 0.033; BQI: β = 0.295, p = 0.007; BMI − SOS: β = 0.207, p = 0.064; BUA: β = 0.455, p < 0.001; BQI: β = 0.284, p = 0.008; and age -SOS: β = 0.450, p < 0.001; BUA: β = 0.318, p = 0.004; BQI: β = 0.444, p < 0.001).Conclusions: Changes in the characteristics of ultrasound bone parameters among 10-12 years old children mainly depended on the amount of intense PA, adequate vitamin K intake and anthropometric variables related to age.

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“…QUS, measuring the attenuation and velocity of ultrasound waves passing through the calcaneus bone, is now part of bone health assessment [28]. It has been reported that Broadband Ultrasound Attenuation (BUA) and Speed of Sound (SOS) exhibit distinct structural properties of bone, with BUA more related to structural parameters such as connectivity and porosity of the skeleton, and SOS more influenced by bone mineral mass and elasticity [29].…”

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confidence: 99%

Body Composition and Bone Mineral Quality in Phenylketonuria: Influence of Pubertal Development

Tummolo¹,

Aricò²,

Pesce³

et al. 2021

jendocrdisord

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Background/Objectives: Early diagnosis and a low-Phe diet significantly improved prognosis of PKU patients whose management is now-a-day mostly focused on preventing nutritional imbalances and resulting comorbidities. Puberty is a turning point for the risk to develop overweight and bone quality impairment. The present study aims to evaluate body composition and bone quality in prepubertal and pubertal PKU patients. Subjects/Methods: This is an observational, prospective study on an historical cohort of patients with PKU aged between 4.1 and 18 years, with early diagnosis and continuous protein-restrictive diet treatment. Bioimpedance, weight measurements, height, body mass index calculation, and quantitative ultrasound were collected. Sexual maturity was evaluated by using the Tanner staging. Results: Thirty PKU patients (14 prepubertal, 16 pubertal) were included in the study. Mean BMI was within the normal range in both groups, although fat content was higher in prepubertal, whereas lean mass was higher in the pubertal group who had also a higher total protein content. Among QUS parameters, bone quality index and broadband ultrasound were lower in prepubertal children than in adolescents, with a Z-score BQI within the osteopenia range in both of them. Conclusions: Pubertal patients with PKU develop a higher lean mass and protein content. If on one hand the high non-Phe protein intake in the pubertal period may promote increase in bone mineral quality, on the other hand the higher protein retention, typical of this period, may increase the risk for hyperinsulinism and glucose intolerance in later life. Adjusting dietary management by modulating total protein intake in the peripubertal period could result in better management of PKU patients.

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Longitudinal changes in calcaneal quantitative ultrasound measures during childhood

Cited by 14 publications

References 67 publications

Body composition and bone mineral status in patients with Turner syndrome

Body composition and bone mineral status in patients with Turner syndrome

Relationship between physical activity, dietary intake and bone parameters in 10-12 years old Hungarian boys and girls

Body Composition and Bone Mineral Quality in Phenylketonuria: Influence of Pubertal Development

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