Longitudinal Cerebral Perfusion Decrease in Mild Alzheimer’s Disease Revealed by SPECT with Statistical Parametric Mapping Method

Abstract

Fifteen patients with mild Alzheimer’s disease received baseline and follow-up technetium-99m hexamethylpropylene amine oxime SPECT examinations paired with neuropsychological assessments, including the Cognitive Ability Screening Instruments (CASI). The differences between baseline and follow-up SPECT images were analyzed by the voxel-based paired t test of the statistical parametric mapping technique. A simple regression analysis was also conducted to analyze the correlation between CASI sub-scores and both sets of SPECT images. In comparison with baseline images, cerebral perfusion at follow-up was significantly reduced in the left superior and middle temporal gyri, right middle and inferior temporal gyri, and right fusiform gyrus. A significant correlation was demonstrated between the list-generating fluency CASI sub-score and perfusion of the left fusiform gyrus. The visual construction sub-score was significantly correlated with perfusion of the right superior and medial frontal gyri.

Longitudinal changes in cerebral blood flow and their relation with cognitive decline in patients with dementia: Current knowledge and future directions

“…Fourteen studies, 20–23,50,52–60 including 21 patient (sub)groups, reported on longitudinal changes in rCBF in smaller brain regions (Table 3), such as specific gyri that have been associated with AD pathology. Although longitudinal increases in rCBF have been rarely observed, two studies found an increase in the postcentral gyrus 20,59 .…”

“…For consensus, disagreements were resolved by discussion and/or by consulting a third reviewer (JC). Eventually, 20 studies [19][20][21][22][23][24][47][48][49][50][51][52][53][54][55][56][57][58][59][60] were included in this systematic review, including five studies [19][20][21][22][23] eligible for quantitative synthesis. A flowchart of the study identification and selection process can be found in Figure 1.…”