Longitudinal brain magnetic resonance imaging of children with perinatal Chikungunya encephalitis

Corrêa, Diogo Goulart; Ferreira, Fátima Cristiane Pinho de Almeida Di Maio; Cruz, Luiz Celso Hygino da; Brasil, Patrícia; Lopes, Fernanda Cristina Rueda

doi:10.1177/1971400920959070

Cited by 4 publications

(4 citation statements)

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“…Most studies (n = 35; 83,3%) were case reports and case series [9,[16][17][18][19][20][21][23][24][25][26][27][28][29][30][31][32][33][34][35][36][37][38][39][40][41][42][45][46][47][48][49][51][52][53]. The clinical and perinatal manifestations of pregnancy and the outcome of gestation were described in ten studies [9,10,[16][17][18][19][20][21]23,25,27,[49][50][51]. Stillbirths and miscarriage associated with CHIKV vertical transmission with laboratory evidence were reported in three studies …”

Section: Characteristics Of Selected Studiesmentioning

confidence: 99%

“…All included studies (n = 42) reported CHIKV vertical transmission confirmed by laboratory and clinical-epidemiological evidence in pregnant women (Table 1). The maternal infection diagnosis was confirmed by molecular and serological tests in 31 (73.8%) studies [6,9,10,[16][17][18][19][20][21][22][23][24][25][26][27][28]30,31,[33][34][35]39,41,[43][44][45][47][48][49][50][51]53,54] and in 243 (96.8%) women.…”

Section: Pregnancy Outcome Clinical and Perinatal Characteristics Of The Pregnant Women (Table 2)mentioning

confidence: 99%

“…Only in twelve studies (28.5%), magnetic resonance imagery (MRI) was done, demonstrating the evolution of lesions from edema to cavitation or subcortical atrophy [5,16,18,29,55].…”

Section: Neonate Outcomes (Table 2)mentioning

confidence: 99%

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Vertical transmission of chikungunya virus: A systematic review

et al. 2021

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Objectives To describe and estimate the frequency of pregnancy outcomes, clinical and laboratory characteristics of vertical transmission of CHIKV in the neonate. Study design We performed a systematic review evaluating the clinical presentation of perinatally-acquired CHIKV infection in neonates. The search was performed using Medline (via PubMed), LILACS, Web of Science, Scielo, Google Scholar and Open grey to identify studies assessing vertical transmission of CHIKV up to November 3, 2020. There were no search restrictions regarding the study type, the publication date or language. Studies with no documented evidence of CHIKV infection in neonates (negative RT-PCR or absence of IgM) were excluded. Results From the 227 studies initially identified, 42 were selected as follows: 28 case reports, 7 case series, 2 cross-sectional studies and 5 cohort studies, for a total of 266 CHIKV infected neonates confirmed by serological and/or molecular tests. The vertical transmission rate was 50% in the Reunion Island outbreak, which was the subject of the majority of the studies; the premature delivery were reported in 19 (45.2%) studies; the rate of fetal distress was 19.6% of infected babies and fetal loss occurred in 2% of the cases. Approximately 68.7% of newborns were diagnosed with encephalopathy or encephalitis after perinatally acquired CHIKV. Most of the infected neonates were born healthy, developing CHIKV sepsis clinical syndrome within the first week of life. Conclusions We alert neonatologists to the late manifestations of neonatal CHIKV infection, relevant to the management and reduction of morbidity. A limitation of our review was that it was not possible to carry out meta-analysis due to differences in study design and the small number of participants.

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Section: Characteristics Of Selected Studiesmentioning

confidence: 99%

Section: Pregnancy Outcome Clinical and Perinatal Characteristics Of The Pregnant Women (Table 2)mentioning

confidence: 99%

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Vertical transmission of chikungunya virus: A systematic review

et al. 2021

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“…Moreover, long-term sequelae can occur after infection. During the CHIKV epidemic in Brazil, atypical and severe cases were reported, including neuronal impairment in adults and newborns (mother-to-child infection) [ 149 , 150 , 151 , 152 , 153 ].…”

Section: Viruses Commonly Associated With Cns Infection In Brazilmentioning

confidence: 99%

Viral and Prion Infections Associated with Central Nervous System Syndromes in Brazil

Sousa

Santos

Paula

et al. 2021

Viruses

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Virus-induced infections of the central nervous system (CNS) are among the most serious problems in public health and can be associated with high rates of morbidity and mortality, mainly in low- and middle-income countries, where these manifestations have been neglected. Typically, herpes simplex virus 1 and 2, varicella-zoster, and enterovirus are responsible for a high number of cases in immunocompetent hosts, whereas other herpesviruses (for example, cytomegalovirus) are the most common in immunocompromised individuals. Arboviruses have also been associated with outbreaks with a high burden of neurological disorders, such as the Zika virus epidemic in Brazil. There is a current lack of understanding in Brazil about the most common viruses involved in CNS infections. In this review, we briefly summarize the most recent studies and findings associated with the CNS, in addition to epidemiological data that provide extensive information on the circulation and diversity of the most common neuro-invasive viruses in Brazil. We also highlight important aspects of the prion-associated diseases. This review provides readers with better knowledge of virus-associated CNS infections. A deeper understanding of these infections will support the improvement of the current surveillance strategies to allow the timely monitoring of the emergence/re-emergence of neurotropic viruses.

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Chikungunya Encephalitis: an Inconsistently Reported Headache and Cause of Death in Patients with Pre-Existing Conditions

2022

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Chikungunya virus (CHIKV) is an alphavirus of the family Togaviridae with outbreaks occurring across Africa, Asia, parts of Europe, and South and Central America. There are three main lineages of CHIKV, including the West African lineage, the East Central South African (ECSA) lineage, and the Asian lineage. While CHIKV infection usually results in a self-limited febrile illness, there have been reports of concerning neurological manifestations, including encephalitis. Herein we discuss findings of over 700 cases of CHIKV encephalitis and risk factors for death. Additionally, we examined the genotypes of CHIKV associated with encephalitis and found that both the Asian and ECSA lineages were responsible for encephalitis but not the West African lineage. Protein analysis of consensus sequences of CHIKV strains associated with encephalitis identified mutations in the nsP1, nsP2, and nsP3 proteins. Reports and manuscripts of CHIKV encephalitis were inconsistent in reporting viral, demographic, and clinical features which complicated the delineation of risk factors associated with the disease and viral evolution. As climate change contributes to the range expansion of natural vectors, it is important for researchers and clinicians to consistently report patient and viral data to facilitate research and countermeasures for the ecology and epidemiology of CHIKV due to the lack of a targeted treatment or vaccine.

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Longitudinal brain magnetic resonance imaging of children with perinatal Chikungunya encephalitis

Cited by 4 publications

References 16 publications

Vertical transmission of chikungunya virus: A systematic review

Vertical transmission of chikungunya virus: A systematic review

Viral and Prion Infections Associated with Central Nervous System Syndromes in Brazil

Chikungunya Encephalitis: an Inconsistently Reported Headache and Cause of Death in Patients with Pre-Existing Conditions

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