Longitudinal associations of physical activity with plasma metabolites among colorectal cancer survivors up to 2 years after treatment

Abstract

We investigated longitudinal associations of moderate-to-vigorous physical activity (MVPA) and light-intensity physical activity (LPA) with plasma concentrations of 138 metabolites after colorectal cancer (CRC) treatment. Self-reported physical activity data and blood samples were obtained at 6 weeks, and 6, 12 and 24 months post-treatment in stage I-III CRC survivors (n = 252). Metabolite concentrations were measured by tandem mass spectrometry (BIOCRATES AbsoluteIDQp180 kit). Linear mixed models were used to evaluate confounder-adjusted longitudinal associations. Inter-individual (between-participant differences) and intra-individual associations (within-participant changes over time) were assessed as percentage difference in metabolite concentration per 5 h/week of MVPA or LPA. At 6 weeks post-treatment, participants reported a median of 6.5 h/week of MVPA (interquartile range:2.3,13.5) and 7.5 h/week of LPA (2.0,15.8). Inter-individual associations were observed with more MVPA being related (FDR-adjusted q-value < 0.05) to higher concentrations of arginine, citrulline and histidine, eight lysophosphatidylcholines, nine diacylphosphatidylcholines, 13 acyl-alkylphosphatidylcholines, two sphingomyelins, and acylcarnitine C10:1. No intra-individual associations were found. LPA was not associated with any metabolite. More MVPA was associated with higher concentrations of several lipids and three amino acids, which have been linked to anti-inflammatory processes and improved metabolic health. Mechanistic studies are needed to investigate whether these metabolites may affect prognosis.

Effect of WeChat-Based Health Education Combined with Satir Model on Self-Management Behaviors and Social Adaptation in Colorectal Cancer Patients during the Perioperative Period

“…For surgical CRC patients, the Satir model is an effective tool for them to face their physiological changes, and its positive meaning lies in that the patients can deeply feel that they are not alone in fighting the disease and that there are many people facing the same situation, thereby alleviating their loneliness and inferiority feeling. In addition, compared to the conventional psychological intervention, the Satir model improves the patients' trust [ 23 ]. To be specific, in a relaxed and loving group atmosphere, the patients can gradually build a sense of communication and trust to share their own experiences with those undergoing the same situation and benefit from the positive experiences of others.…”

Longitudinal associations of plasma metabolites with persistent fatigue among colorectal cancer survivors up to 2 years after treatment

“…The Absolute IDQ p180 kit (BIOCRATES Life Sciences AG, Austria) was applied for targeted metabolomics analysis at the International Agency for Research on Cancer (IARC), Lyon, France, as previously described 23 . Briefly, the kit measures a panel of up to 188 metabolites, including acylcarnitines, amino acids, biogenic amines, a sum of hexoses, phosphatidylcholines (PCs), including lysoPCs, diacylPCs, and acyl‐alkylPCs, and sphingomyelins (SMs).…”

“…including heat maps of correlations and the longitudinal development over time have previously been reported. 23 During the posttreatment period, reported mean levels of fatigue, including the total fatigue score and all subdomains, decreased over time (Figure 1). In linear mixed models with only time since treatment as independent variable and using data for men and women combined, statistically significant negative changes over time were observed for the "total fatigue" score (β, that is, change in fatigue score per 6 months: À3.0; 95% CI: À4.1, À2.0), "fatigue severity" (β: À1.7, 95% CI: À2.2, À1.1), "reduced motivation" (β: À0.5; 95% CI: À0.8, À0.2) and "reduced activity" (β: À0.7; 95% CI: À1.0, À0.5), while a nonsignificant and small negative change was found for "concentration problems" (β: À0.1; 95% CI: À0.4, 0.2).…”

“…The EnCoRe study is an ongoing prospective cohort study, which was For the current analysis, we used data collected up until November 1, 2016 as described in a previous publication on self-reported physical activity in relation to these metabolite data. 23 In the current analysis on targeted metabolite data and fatigue, individuals with at least one posttreatment measurement of targeted metabolomics, selfreported fatigue, and covariates were included (n = 252, 69% men).…”

“…There is a need for confounder‐adjusted longitudinal studies to investigate how changes in metabolite concentrations are associated with changes in fatigue in the years after colorectal cancer treatment. We recently published results of a longitudinal analysis of associations of self‐reported physical activity in relation to targeted metabolite data among colorectal cancer survivors up to 2 years posttreatment, using data of the Energy for Life after ColoRectal Cancer (EnCoRe) study 23 . In the current analysis, we investigated longitudinal associations of plasma concentrations of 138 targeted metabolites with total fatigue and subdomains of fatigue up to 2 years after colorectal cancer treatment in the same study sample.…”