Longitudinal association between epilepsy and schizophrenia:A population-based study

Fruchter, Eyal; Kapara, Ori; Reichenberg, Avi; Yoffe, Rinat; Fono-Yativ, Oshrat; Kreiss, Yitshak; Davidson, Michael; Weiser, Mark

doi:10.1016/j.yebeh.2013.10.026

Cited by 32 publications

(4 citation statements)

References 13 publications

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“…The screening procedure includes medical, psychiatric, and cognitive assessments, in addition to collection of socio-demographic data. A detailed description of the pre-induction screening procedure is available elsewhere (Fruchter et al, 2014). The psychiatric diagnoses examined in this study correspond to the International Classification of Diseases (ICD) criteria and include personality disorders, non-affective psychosis, minor affective and anxiety disorders, major affective disorder, adjustment disorder, and substance abuse.…”

Section: Methodsmentioning

confidence: 99%

Functioning of Young Adults With ADHD in the Military

Fruchter¹,

Marom-Harel

Fenchel

et al. 2016

J Atten Disord

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Section: Methodsmentioning

confidence: 99%

Functioning of Young Adults With ADHD in the Military

Fruchter¹,

Marom-Harel

Fenchel

et al. 2016

J Atten Disord

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“…1G and S6B). When using Functional Annotation Clustering a representative term of that cluster was presented and the full datasets are presented in supplementary tables (Supplementary Table 2,4,6). Only Benjamini-Hochberg (BH) adjusted p-values were used in all results.…”

Section: Gene Ontology Analysismentioning

confidence: 99%

“…NPDs such as autism spectrum disorder (ASD), schizophrenia (SZ), intellectual disability (ID) are known to share behavioral symptoms and comorbidities 3,4,5 . Notably, all these conditions have a strong epidemiological association with epilepsy, indicating the potential for shared risk mechanisms 6,7,8,9 . Epilepsy is frequently comorbid in individuals with ASD, with (22%) or without (8%) ID, while ASDs occurs in 4-20% of children with epilepsy 7,10,11 .…”

Section: Introductionmentioning

confidence: 99%

Rescue of neuropsychiatric phenotypes in a mouse model of 16p11.2 duplication syndrome by genetic correction of an epilepsy network hub

Forrest

Santos

Piguel

et al. 2022

Preprint

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Neuropsychiatric disorders (NPDs) share genetic etiology and are frequently co-morbid with epilepsy, but the biological basis of this shared risk remains poorly understood. The 16p11.2 microduplication (16p11.2dup/+) is a highly pleiotropic copy number variant (CNV) conferring risk for multiple NPDs including autism spectrum disorder, schizophrenia and intellectual disability, and is associated with a high prevalence of seizures. We used a mouse model of the 16p11.2 duplication (16p11.2dup/+) to uncover molecular and circuit properties associated with this broad phenotypic spectrum, and examined genes within the locus capable of phenotype reversal. Quantitative proteomics of cortical membranes revealed alterations to synaptic protein networks and products of diverse NPD risk genes in 16p11.2dup/+ mice. Network analysis identified an epilepsy-associated protein subnetwork, which was dysregulated in 16p11.2dup/+ mice and proteomic datasets from human NPDs. We investigated circuit properties in 16p11.2dup/+ mice and found they exhibited hypersynchronous activity and enhanced network glutamate release, which increased susceptibility to seizures. We hypothesized that a regulator of the synaptic and epilepsy-associated protein network could have an important impact on pathophysiology. Human brain co-expression and interactome analysis revealed PRRT2 as a major hub in the dysregulated epilepsy subnetwork. Remarkably, restoring Prrt2 copy number to wild-type levels rescued aberrant circuit properties, seizure susceptibility and social interaction deficits in 16p11.2dup/+ mice. We show that proteomics and network biology can identify important disease hubs in multigenic CNVs, and reveal molecular and circuit phenotypes which may be relevant to the complex symptomatology of 16p11.2 duplication carriers.

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“…NPDs such as autism spectrum disorder (ASD), schizophrenia (SZ), intellectual disability (ID) are known to share behavioral symptoms and co-morbidities 3 – 5 . Notably, all these conditions have a strong epidemiological association with epilepsy, indicating the potential for shared risk mechanisms 6 – 9 . Epilepsy is frequently comorbid in individuals with ASD, with (22%) or without (8%) ID, while ASDs occurs in 4–20% of children with epilepsy 7 , 10 , 11 .…”

Section: Introductionmentioning

confidence: 99%

Rescue of neuropsychiatric phenotypes in a mouse model of 16p11.2 duplication syndrome by genetic correction of an epilepsy network hub

et al. 2023

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Neuropsychiatric disorders (NPDs) are frequently co-morbid with epilepsy, but the biological basis of shared risk remains poorly understood. The 16p11.2 duplication is a copy number variant that confers risk for diverse NPDs including autism spectrum disorder, schizophrenia, intellectual disability and epilepsy. We used a mouse model of the 16p11.2 duplication (16p11.2dup/+) to uncover molecular and circuit properties associated with this broad phenotypic spectrum, and examined genes within the locus capable of phenotype reversal. Quantitative proteomics revealed alterations to synaptic networks and products of NPD risk genes. We identified an epilepsy-associated subnetwork that was dysregulated in 16p11.2dup/+ mice and altered in brain tissue from individuals with NPDs. Cortical circuits from 16p11.2dup/+ mice exhibited hypersynchronous activity and enhanced network glutamate release, which increased susceptibility to seizures. Using gene co-expression and interactome analysis, we show that PRRT2 is a major hub in the epilepsy subnetwork. Remarkably, correcting Prrt2 copy number rescued aberrant circuit properties, seizure susceptibility and social deficits in 16p11.2dup/+ mice. We show that proteomics and network biology can identify important disease hubs in multigenic disorders, and reveal mechanisms relevant to the complex symptomatology of 16p11.2 duplication carriers.

show abstract

Longitudinal association between epilepsy and schizophrenia:A population-based study

Cited by 32 publications

References 13 publications

Functioning of Young Adults With ADHD in the Military

Functioning of Young Adults With ADHD in the Military

Rescue of neuropsychiatric phenotypes in a mouse model of 16p11.2 duplication syndrome by genetic correction of an epilepsy network hub

Rescue of neuropsychiatric phenotypes in a mouse model of 16p11.2 duplication syndrome by genetic correction of an epilepsy network hub

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