Longitudinal Assessments of Quality of Life in Endometrial Cancer Patients: Effect of Surgical Approach and Adjuvant Radiotherapy

Le, Tien; Menard, Chantal; Samant, Rajiv; Choan, E; Hopkins, Laura; Faught, Wylam; Fung-Kee-Fung, Michael

doi:10.1016/j.ijrobp.2008.11.018

Cited by 18 publications

(15 citation statements)

References 25 publications

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“…Our findings also suggest that age, body image, and relationship quality and pain may place women surgically treated for endometrial cancer at higher risk for sexual difficulties. Psychological and sexual morbidity connected with gynecologic cancer 12,13 both in the immediate posttreatment period 4,14,16 and in long-term survivorship 7,18 has been described in the literature. Despite the noted difficulties within our sample, improvement in sexual function and decreased fear of sex was seen by 6 months after surgery in those who responded to sexual function items.…”

Section: Discussionmentioning

confidence: 99%

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Sexual Function of Patients With Endometrial Cancer Enrolled in the Gynecologic Oncology Group LAP2 Study

Carter¹,

Huang

Chase

et al. 2012

International Journal of Gynecological Cancer

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Objectives To present responses to sexual function items contained within the quality of life (QOL) survey of the Gynecologic Oncology Group (GOG) LAP2 study, to investigate associations between sexual function and other factors such as relationship quality and body image), and to explore patterns of response in endometrial cancer patients. Methods Participants enrolled on the LAP2 QOL study arm completed a self-report QOL survey, which contained sexual function items, before surgery, and at 1, 3, 6-weeks and 6-months post surgery. Responses to sexual function questions were classified into three patterns—responder, intermittent responder and non-responder—based on whether the sexual function items were answered when the QOL survey was completed. Results Of 752 patients who completed the QOL survey, 225 completed the sexual function items within the QOL survey, 224 responded intermittently, and 303 did not respond at all. No significant differences of sexual function were found between the patients randomized to laparoscopy compared to laparotomy. Among those who responded completely or intermittently, sexual function scores declined after surgery and recovered to pre-surgery levels at 6 months. Sexual function was positively associated with better quality of relationship (P<0.001), body image (P<0.001), and QOL (P<0.001), and negatively associated with fear of sex (P<0.001). Conclusion Our findings suggest that younger patients, those who were married, and those who had quality relationships were more likely to answer the sexual function items and have better quality of sexual function. Factors such as age, relationship quality, body image, and pain may place women with endometrial cancer at risk for sexual difficulties in the immediate recovery period; however, sexual function improved by 6-months postoperatively in our cohort of early-stage endometrial cancer patients.

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Section: Discussionmentioning

confidence: 99%

“…10 Sexual morbidity is associated with poor psychological adjustment and QOL in gynecologic cancer survivors 11Y14 both immediately after treatment 4,14,15 and in long-term survivorship. 16Y18 Data on sexual dysfunction vary greatly within the gynecologic oncology literature.…”

mentioning

confidence: 99%

Sexual Function of Patients With Endometrial Cancer Enrolled in the Gynecologic Oncology Group LAP2 Study

Carter¹,

Huang

Chase

et al. 2012

International Journal of Gynecological Cancer

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“…Few articles measured the impacts of RT on the PFM structure or function in women treated for gynecological cancers, even though there are many studies reporting urinary, sexual, or fecal problems after radiotherapy versus surgery alone [4,6,9,12,11,3,52,53]. In this review, only two papers met our criteria and could be included.…”

Section: Effects Of Rt On the Pfm Functionmentioning

confidence: 99%

“…Furthermore, a high prevalence of pelvic floor dysfunctions following radiotherapy for pelvic neoplasms has also been reported: urinary incontinence and urgency [4,5], sexual dysfunction and dyspareunia [6][7][8], and fecal urgency and incontinence [9,10]. Such dysfunctions have been demonstrated not only to cause distress to cancer survivors [11], but also to diminish their participation in activities of daily living and social activities, leading to an overall decreased quality of life [12].…”

Section: Introductionmentioning

confidence: 99%

Effects of radiation therapy on the structure and function of the pelvic floor muscles of patients with cancer in the pelvic area: a systematic review

et al. 2015

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PurposeRadiation therapy (RT) is often recommended in the treatment of pelvic cancers. Following RT, a high prevalence of pelvic floor dysfunctions (urinary incontinence, dyspareunia, and fecal incontinence) is reported. However, changes in pelvic floor muscles (PFMs) after RT remain unclear. The purpose of this review was to systematically document the effects of RT on the PFM structure and function in patients with cancer in the pelvic area.

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“…Sexual morbidity is associated with poor psychologic adjustment and QOL in women treated for gynecologic cancer 19–21 in the immediate posttreatment period 16,22,23 and in long-term survival. 24,25 Dyspareunia, vaginal dryness, and loss of desire are the most common sexual difficulties after cancer treatment.…”

Section: Cancer Treatment and Sexualitymentioning

confidence: 99%

Contemporary Quality of Life Issues Affecting Gynecologic Cancer Survivors

Carter

Penson

Barakat

et al. 2012

Hematology/Oncology Clinics of North America

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Gynecologic cancers account for approximately 11% of the newly diagnosed cancers in women in the United States and 18% in the world.1 The most common gynecologic malignancies occur in the uterus and endometrium (53%), ovary (25%), and cervix (14%).2 Cervical cancer is most prevalent in premenopausal women, during their childbearing years, whereas uterine and ovarian cancers tend to present in the perimenopausal or menopausal period. Vaginal and vulvar cancers and malignancies arising from gestation, or gestational trophoblastic neoplasms, occur to a lesser extent. Regardless of cancer origin or age of onset, the disease and its treatment can produce short- and long-term sequelae (ie, sexual dysfunction, infertility, or lymphedema) that adversely affect quality of life (QOL). This article outlines the primary contemporary issues or concerns that may affect QOL and offers strategies to offset or mitigate QOL disruption. These contemporary issues are identified within the domains of sexual functioning, reproductive issues, lymphedema, and the contribution of health-related QOL (HRQOL) in influential gynecologic cancer clinical trials.

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Longitudinal Assessments of Quality of Life in Endometrial Cancer Patients: Effect of Surgical Approach and Adjuvant Radiotherapy

Cited by 18 publications

References 25 publications

Sexual Function of Patients With Endometrial Cancer Enrolled in the Gynecologic Oncology Group LAP2 Study

Sexual Function of Patients With Endometrial Cancer Enrolled in the Gynecologic Oncology Group LAP2 Study

Effects of radiation therapy on the structure and function of the pelvic floor muscles of patients with cancer in the pelvic area: a systematic review

Contemporary Quality of Life Issues Affecting Gynecologic Cancer Survivors

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