Longitudinal assessment of the neuroanatomical consequences of deep brain stimulation: Application of fornical DBS in an Alzheimer’s mouse model

Gallino, Daniel; Devenyi, Gabriel A.; Germann, Jürgen; Guma, Elisa; Anastassiadis, Chloe; Chakravarty, M. Mallar

doi:10.1016/j.brainres.2019.03.030

Cited by 24 publications

(25 citation statements)

References 52 publications

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“…Recently, Gallino et al designed an experiment of fornix DBS in an Alzheimer's mouse model [77]. It combined brain imaging and behaviour by a proof-of-concept methodology in longitudinal assessments.…”

Section: Alzheimer's Disease (Ad)mentioning

confidence: 99%

The effect of fornix deep brain stimulation in brain diseases

Liu

Temel

Boonstra

et al. 2020

Cell. Mol. Life Sci.

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Deep brain stimulation is used to alleviate symptoms of neurological and psychiatric disorders including Parkinson's disease, epilepsy, and obsessive-compulsive-disorder. Electrically stimulating limbic structures has been of great interest, and in particular, the region of the fornix. We conducted a systematic search for studies that reported clinical and preclinical outcomes of deep brain stimulation within the fornix up to July 2019. We identified 13 studies (7 clinical, 6 preclinical) that examined the effects of fornix stimulation in Alzheimer's disease (n = 9), traumatic brain injury (n = 2), Rett syndrome (n = 1), and temporal lobe epilepsy (n = 1). Overall, fornix stimulation can lead to decreased rates of cognitive decline (in humans), enhanced memory (in humans and animals), visuo-spatial memorization (in humans and animals), and improving verbal recollection (in humans). While the exact mechanisms of action are not completely understood, studies suggest fornix DBS to be involved with increased functional connectivity and neurotransmitter levels, as well as enhanced neuroplasticity.

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Section: Alzheimer's Disease (Ad)mentioning

confidence: 99%

The effect of fornix deep brain stimulation in brain diseases

Liu

Temel

Boonstra

et al. 2020

Cell. Mol. Life Sci.

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“…Most experiments in animal research are dominated by male animals. Fornix DBS can significantly improve the performance of male mice in the water maze without affecting the performance of females (Gallino et al, 2019). Human clinical studies have not considered the sex of patients with AD.…”

Section: Discussionmentioning

confidence: 99%

“…One hour of fornix DBS improved spatial memory deficits and caused local volume differences in various regions of the brain in AD mice. These changes can last at least 45 days, suggesting that the role of DBS in AD is more than immediate (Gallino et al, 2019). The improvement of spatial memory and recognition memory caused by DBS for 24 h in the AD rat model induced by Aβ 42 can last for at least 4 weeks (Zhang et al, 2015).…”

Section: Stimulation Durationmentioning

confidence: 99%

“…Since then, DBS in the fornix has gradually been applied to AD. Chronic fornix DBS can stabilize or slow memory decline and increase hippocampal volume and cerebral metabolism in some patients with AD (Laxton et al, 2010;Smith et al, 2012;Fontaine et al, 2013;Sankar et al, 2015;Lozano et al, 2016) and improve spatial learning memory and recognition memory and reduce amyloidosis, the inflammatory response, the loss of neurons and the local changes in brain volume in AD model mice (Hescham et al, 2013b;Zhang et al, 2015;Gallino et al, 2019;Leplus et al, 2019). Therefore, the fornix is a good target choice for the treatment of DBS in human clinical research and animal research on AD (Senova et al, 2020).…”

Section: Fornixmentioning

confidence: 99%

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Deep Brain Stimulation for Alzheimer's Disease: Stimulation Parameters and Potential Mechanisms of Action

Luo

Sun

Tian

et al. 2021

Front. Aging Neurosci.

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Deep brain stimulation (DBS) is a neurosurgical technique that regulates neuron activity by using internal pulse generators to electrodes in specific target areas of the brain. As a blind treatment, DBS is widely used in the field of mental and neurological diseases, although its mechanism of action is still unclear. In the past 10 years, DBS has shown a certain positive effect in animal models and patients with Alzheimer's disease (AD), but there are also different results that may be related to the stimulation parameters of DBS. Based on this, determining the optimal stimulation parameters for DBS in AD and understanding its mechanism of action are essential to promote the clinical application of DBS in AD. This review aims to explore the therapeutic effect of DBS in AD, and to analyze its stimulation parameters and potential mechanism of action. The keywords “Deep brain stimulation” and “Alzheimer's Disease” were used for systematic searches in the literature databases of Web of Science and PubMed (from 1900 to September 29, 2020). All human clinical studies and animal studies were reported in English, including individual case studies and long-term follow-up studies, were included. These studies described the therapeutic effects of DBS in AD. The results included 16 human clinical studies and 14 animal studies, of which 28 studies clearly demonstrated the positive effect of DBS in AD. We analyzed the current stimulation parameters of DBS in AD from stimulation target, stimulation frequency, stimulation start time, stimulation duration, unilateral/bilateral treatment and current intensity, etc., and we also discussed its potential mechanism of action from multiple aspects, including regulating related neural networks, promoting nerve oscillation, reducing β-amyloid and tau levels, reducing neuroinflammation, regulating the cholinergic system, inducing the synthesis of nerve growth factor.

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“…Stimulation of LN structures has been found to reverse patterns of atrophy seen in rodent models of AD. Stimulating the fornix, Gallino et al demonstrated volumetric changes, including increases in the superior colliculus, dorsal subiculum, rostral thalamus, and cerebral peduncle, but decreases in the inferior colliculus, dorsomedial periaqueductal gray, and fimbria (275). Interestingly, males and females showed differential volumetric changes, suggesting hormonal and/or developmental differences in response to stimulation (275).…”

Section: Dbs In Ad: Evidence From Animal Studiesmentioning

confidence: 99%