Longitudinal assessment of myocardial function in childhood chronic kidney disease, during dialysis, and following kidney transplantation

Abstract

There are differences in diastolic parameters in childhood CKD that persist during dialysis and after transplantation. Systolic parameters are preserved, with significant improvement in systolic myocardial deformation following transplantation. The impact of persistent diastolic changes on long-term outcomes requires further investigation.

Changes in cardiac function after renal transplantation in children: Significance of pre‐transplantation left ventricular hypertrophy

“…However, the LVMI did not change in children without LVH before RTx. Although some investigators have reported controversial findings regarding the change in the LVMI associated with RTx in children, this study specifically evaluated the LVMI according to the presence of pre‐existing LVH.…”

“…Accordingly, removal of volume overload and uremic toxins following RTx is likely to lead to the improvement of LVH. However, the effects of RTx on cardiac function in children with CKD remain controversial …”

“…However, the effects of RTx on cardiac function in children with CKD remain controversial. 2,[7][8][9] On the background of these controversial results in children, classification by the presence of baseline LVH might have a significant effect on transition of the LVMI after RTx. As shown in Table 3 Regardless, most patients maintained their BP Z-score at <2.0 during the study period, and children without LVH before RTx exhibited no significant change in their LVMI and a slight increase in their LVM (58.49 ± 29.99 vs 65.93 ± 32.88, P = .059).…”

“…RTx will correct these factors; therefore, successful RTx should improve the cardiovascular risk factors inherent to CKD and recover the recipients from LVH. However, the effect of RTx on LVH in children has been controversial . The variation in cardiac function before RTx in children might be associated with the controversial results that have been obtained to date.…”

“…been controversial. 2,[7][8][9] The variation in cardiac function before RTx in children might be associated with the controversial results that have been obtained to date. Actually, in adults, LVH before RTx can reportedly modulate the transition of cardiac function following RTx.…”