Longitudinal and prospective assessment of prenatal maternal sleep quality and associations with newborn hippocampal and amygdala volume

Nevarez-Brewster, Melissa; Demers, Catherine H.; Mejia, Alexandra; Haase, Mercedes Hoeflich; Bagonis, Maria M.; Kim, Sun Hyung; Gilmore, John H.; Hoffman, M. Camille; Styner, Martin; Hankin, Benjamin L.; Davis, Elysia Poggi

doi:10.1016/j.dcn.2022.101174

Cited by 7 publications

(5 citation statements)

References 79 publications

(117 reference statements)

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“…Circadian rhythms have been found to synchronize between mother and fetus [5][6][7] , and irregular maternal sleep-wake cycles may disrupt the synchronization of circadian rhythms between mother and fetus, in turn negatively impacting fetal neurodevelopment 8 . Altered brain development may also be a mechanism through which maternal prenatal sleep is associated with poorer infant outcomes; indeed, emerging evidence indicates that maternal sleep and circadian disturbances during pregnancy are associated with structural brain alterations in neonates 18,19 . Environmental in uences such as maternal stress, depression, and/or maternal postnatal sleep disturbances may also help explain these associations 34 .…”

Section: Discussionmentioning

confidence: 99%

“…To retain the largest sample size possible, we focused our analysis on the mean of the data collected over all three trimesters. However, previous research has identi ed trimester-speci c effects of maternal sleep disturbances on offspring outcomes 12,19 , so we have included a trimester-speci c analysis in Supplemental Appendix A (Supplemental Tables S1 and S2).…”

Section: Measures Maternal Sleep and Circadian Rhythms During Pregnancymentioning

confidence: 99%

“…Even less research has explored whether human maternal sleep and circadian rhythm disturbances during pregnancy relate to child socioemotional outcomes. Emerging evidence indicates that maternal sleep and circadian disturbances during pregnancy are associated with structural brain alterations in neonates 18,19 , and these brain alterations may be a possible pathway through which later socioemotional development is affected. In addition, infants of mothers who reported having poor quality sleep and short sleep durations during pregnancy demonstrated increased irritability at one month of age 16 .…”

Section: Introductionmentioning

confidence: 99%

“…3 , and altered neonatal brain volumes18,19 . This literature suggests that improving maternal sleep during pregnancy could be a useful target for interventions aimed at reducing maternal and fetal risk for negative outcomes.…”

mentioning

confidence: 99%

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The Association Between Maternal Sleep and Circadian Rhythms During Pregnancy and Infant Sleep and Socioemotional Outcomes

Hoyniak,

Donohue,

Luby

et al. 2024

Preprint

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Studies have established that maternal sleep and circadian rhythm disturbances during pregnancy are associated with poor prenatal and perinatal outcomes for mothers and offspring. However, little work has explored its effects on infant sleep or socioemotional outcomes. The current study examined the relationship between maternal sleep and circadian rhythm disturbances during pregnancy and infant sleep and socioemotional outcomes in a diverse sample of N=193 mothers and their infants (51% White; 52% Female; Mage= 11.95 months). Maternal sleep and circadian rhythms during pregnancy were assessed using self-reports and actigraphy. Mothers reported on infants’ sleep and socioemotional outcomes when infants were one year old. When controlling for infant sex, age, gestational age at birth, and family income-to-needs, mothers who reported more sleep problems during pregnancy had infants with more sleep disturbances and dysregulation (e.g., increased feeding difficulties, sensory sensitivities) when they were one year old. Moreover, mothers who had later sleep timing (i.e., went to bed and woke up later, measured via actigraphy) during pregnancy had infants with more dysregulation and externalizing problems, and mothers with increased intra-daily variability in rest-activity rhythms (as measured via actigraphy) had infants with more externalizing problems. Findings suggest that maternal sleep and circadian rhythm disturbances during pregnancy may be a risk factor for infant sleep problems and socioemotional difficulties.

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Section: Discussionmentioning

confidence: 99%

Section: Measures Maternal Sleep and Circadian Rhythms During Pregnancymentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

mentioning

confidence: 99%

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The Association Between Maternal Sleep and Circadian Rhythms During Pregnancy and Infant Sleep and Socioemotional Outcomes

Hoyniak,

Donohue,

Luby

et al. 2024

Preprint

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“…Poorer sleep across the lifespan is related to higher CVD risk ( 120 – 123 , 156 ). Stress-responsive hormones are involved in the regulation of circadian rhythm ( 157 ), and HPA axis dysregulation is often implicated in sleep disorders ( 158 ), as well as normative variability in sleep ( 159 ), pointing to the importance of stress-responsive hormones in regulating sleep.…”

Section: Prenatal Hormones and Offspring Health Behaviorsmentioning

confidence: 99%

A framework for testing pathways from prenatal stress-responsive hormones to cardiovascular disease risk

et al. 2023

Self Cite

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Cardiovascular disease (CVD) is a leading cause of death globally, with the prevalence projected to keep rising. Risk factors for adult CVD emerge at least as early as the prenatal period. Alterations in stress-responsive hormones in the prenatal period are hypothesized to contribute to CVD in adulthood, but little is known about relations between prenatal stress-responsive hormones and early precursors of CVD, such as cardiometabolic risk and health behaviors. The current review presents a theoretical model of the relation between prenatal stress-responsive hormones and adult CVD through cardiometabolic risk markers (e.g., rapid catch-up growth, high BMI/adiposity, high blood pressure, and altered blood glucose, lipids, and metabolic hormones) and health behaviors (e.g., substance use, poor sleep, poor diet and eating behaviors, and low physical activity levels). Emerging evidence in human and non-human animal literatures suggest that altered stress-responsive hormones during gestation predict higher cardiometabolic risk and poorer health behaviors in offspring. This review additionally highlights limitations of the current literature (e.g., lack of racial/ethnic diversity, lack of examination of sex differences), and discusses future directions for this promising area of research.

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The association between maternal sleep and circadian rhythms during pregnancy and infant sleep and socioemotional outcomes

Hoyniak,

Donohue,

Luby

et al. 2024

Eur Child Adolesc Psychiatry

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Longitudinal and prospective assessment of prenatal maternal sleep quality and associations with newborn hippocampal and amygdala volume

Cited by 7 publications

References 79 publications

The Association Between Maternal Sleep and Circadian Rhythms During Pregnancy and Infant Sleep and Socioemotional Outcomes

The Association Between Maternal Sleep and Circadian Rhythms During Pregnancy and Infant Sleep and Socioemotional Outcomes

A framework for testing pathways from prenatal stress-responsive hormones to cardiovascular disease risk

The association between maternal sleep and circadian rhythms during pregnancy and infant sleep and socioemotional outcomes

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