Longitudinal analysis within one hospital in sub-Saharan Africa over 20 years reveals repeated replacements of dominant clones ofKlebsiella pneumoniaeand stresses the importance to include temporal patterns for vaccine design considerations
Eva Heinz,
Oliver Pearse,
Allan Zuza
et al.
Abstract:Infections caused by multidrug-resistant gram-negative bacteria present a severe threat to global public health. The WHO defines drug-resistantKlebsiella pneumoniaeas a priority pathogen for which alternative treatments are needed given the limited treatment options and the rapid acquisition of novel resistance mechanisms by this species. Longitudinal descriptions of genomic epidemiology ofKlebsiella pneumoniaecan inform management strategies but data from sub-Saharan Africa are lacking.We present a longitudin… Show more
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