Longitudinal analysis of variation in status and diagnostic stability of untreated dry eye disease

Sabucedo-Villamarin, Belén; Pena-Verdeal, Hugo; Garcia-Queiruga, Jacobo; Giráldez, María Jesús; García-Resúa, Carlos; Yebra‐Pimentel, Eva

doi:10.1016/j.jtos.2023.06.004

Cited by 2 publications

(1 citation statement)

References 7 publications

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“…On the other hand, the study design should consider whether different healthcare environments (e.g., primary care, specialized clinics, or emergency departments) may present unique challenges that influence the applicability of the cutoff value. Furthermore, future longitudinal studies are needed to assess the predictive value of TMH|OD-OS| in monitoring disease progression and treatment responses over time [60][61][62].…”

Section: Discussionmentioning

confidence: 99%

A Comprehensive Study on Tear Meniscus Height Inter-Eye Differences in Aqueous Deficient Dry Eye Diagnosis

Pena-Verdeal,

Garcia-Queiruga,

Sabucedo-Villamarin

et al. 2024

JCM

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(1) Background: Dry eye disease (DED) is a chronic ocular surface condition that requires precise diagnostic tools. The present study aimed to investigate the diagnostic potential of the absolute inter-eye difference (|OD-OS|) in tear meniscus height (TMH) for the detection of the presence of aqueous deficient dry eye (ADDE). (2) Methods: A sample of 260 participants with dry eye complaints underwent ocular surface examinations thorough diagnostic assessments based on the Tear Film and Ocular Surface Society guidelines (TFOS DEWS II). Participants were subsequently categorized as No ADDE and ADDE based on TMH. Statistical analyses to determine the optimal TMH|OD-OS| cut-off value in a randomly selected study group (200 participants) were performed, while a separate validation analysis of the cut-off value obtained in a random cross-validation group (60 participants) was also performed. (3) Results: The significant diagnostic capability of TMH|OD-OS| (area under the curve = 0.719 ± 0.036, p < 0.001) was found. The identified cut-off value of 0.033 mm demonstrated reliable specificity (77.6%) and moderate sensitivity (59.1%). Cross-validation confirmed the cut-off value’s association with the TFOS DEWS II diagnostic criterion (Cramer’s V = 0.354, p = 0.006). (4) Conclusions: The present study provides evidence for the diagnostic potential of TMH|OD-OS| in identifying ADDE. The identified cut-off value enhances the specificity and offers moderate sensitivity, providing an objective tool for clinical decision making.

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Section: Discussionmentioning

confidence: 99%

A Comprehensive Study on Tear Meniscus Height Inter-Eye Differences in Aqueous Deficient Dry Eye Diagnosis

Pena-Verdeal,

Garcia-Queiruga,

Sabucedo-Villamarin

et al. 2024

JCM

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Temporal Progression of Entry Factors into the Vicious Circle of Dry Eye in Untreated Sufferers

Garcia-Queiruga,

Pena-Verdeal,

Sabucedo-Villamarin

et al. 2024

Life

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Background: Dry eye disease (DED) is characterized by the loss of ocular surface homeostasis with specific signs and symptoms. Studying the progression of a multifactorial disease is exceedingly challenging for researchers because several factors can influence it. The present study aims to study changes in tear meniscus height (TMH), lipid layer pattern (LLP), and bulbar hyperemia over time in untreated DED participants. Methods: This retrospective longitudinal study included 73 participants (146 eyes) diagnosed with DED since at least 2013. Participants underwent new examinations between 2021 and 2023, grouped by 8-, 6-, or 4-year follow-up periods. TMH, LLP, and bulbar hyperemia were assessed in both examinations. No participant received pharmacological treatment for DED. Results: Differences in TMH, bulbar hyperemia, and LLP between sessions were obtained in the 8-year group (p ≤ 0.027). Differences in bulbar hyperemia and LLP between sessions were obtained in the 6-year group (p ≤ 0.022). The only differences in LLP between sessions were obtained in the 4-year group (p < 0.005). Conclusion: Changes in TMH were obtained after periods of eight years from the first eye examination. Also, changes in bulbar hyperemia were obtained at periods of 8 and 6 years; however, changes in LLP could be found from 4-year follow-ups.

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Longitudinal analysis of variation in status and diagnostic stability of untreated dry eye disease

Cited by 2 publications

References 7 publications

A Comprehensive Study on Tear Meniscus Height Inter-Eye Differences in Aqueous Deficient Dry Eye Diagnosis

A Comprehensive Study on Tear Meniscus Height Inter-Eye Differences in Aqueous Deficient Dry Eye Diagnosis

Temporal Progression of Entry Factors into the Vicious Circle of Dry Eye in Untreated Sufferers

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