Longitudinal analysis of somatic and germ‐cell telomere dynamics in outbred mice

Ramos‐Ibeas, Priscila; Pericuesta, Eva; Peral‐Sanchez, Irene; Heras, Sonia; Laguna‐Barraza, Ricardo; Pérez‐Cerezales, Serafín; Gutiérrez‐Adán, Alfonso

doi:10.1002/mrd.23218

Cited by 9 publications

(7 citation statements)

References 69 publications

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“…Fertilized mouse eggs treated with FCCP, which uncouples the mitochondrial electron transport pathway, also show significantly increased ROS and decreased developmental competence with telomere shortening and chromosomal fusion compared to control embryos (84). In reproductively aged mouse oocytes, Q-PCR and quantitative fluorescence in situ hybridization analyses show significant increase of OS and shortening of telomere lengths (6, 87). Human oocytes with shorter telomeres develop into more fragmented and more aneuploid preimplantation embryos with lower implantation rates (88, 89), whereas relative telomere length was comparable in aneuploid and euploid first polar bodies and blastomeres (90).…”

Section: Introductionmentioning

confidence: 99%

Impact of Oxidative Stress on Age-Associated Decline in Oocyte Developmental Competence

et al. 2019

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Reproductive capacity in women starts to decline beyond their mid-30s and pregnancies in older women result in higher rates of miscarriage with aneuploidy. Age-related decline in fertility is strongly attributed to ovarian aging, diminished ovarian reserves, and decreased developmental competence of oocytes. In this review, we discuss the underlying mechanisms of age-related decline in oocyte quality, focusing on oxidative stress (OS) in oocytes. The primary cause is the accumulation of spontaneous damage to the mitochondria arising from increased reactive oxygen species (ROS) in oocytes, generated by the mitochondria themselves during daily biological metabolism. Mitochondrial dysfunction reduces ATP synthesis and influences the meiotic spindle assembly responsible for chromosomal segregation. Moreover, reproductively aged oocytes produce a decline in the fidelity of the protective mechanisms against ROS, namely the ROS-scavenging metabolism, repair of ROS-damaged DNA, and the proteasome and autophagy system for ROS-damaged proteins. Accordingly, increased ROS and increased vulnerability of oocytes to ROS lead to spindle instability, chromosomal abnormalities, telomere shortening, and reduced developmental competence of aged oocytes.

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Section: Introductionmentioning

confidence: 99%

Impact of Oxidative Stress on Age-Associated Decline in Oocyte Developmental Competence

et al. 2019

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“…Again most data come from mammals, where the picture with respect to age-related changes is mixed. For example, sperm telomeres have been reported to both decline [91] and increase [101] with male age in mice Mus musculus, but decrease in rats Rattus norvegicus [104]. In humans, telomere lengths in sperm have been found to increase with male age [92,105] in contrast to the pattern in somatic tissues [106].…”

Section: (B) Telomere Attrition In the Germlinementioning

confidence: 99%

The deteriorating soma and the indispensable germline: gamete senescence and offspring fitness

2019

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The idea that there is an impenetrable barrier that separates the germline and soma has shaped much thinking in evolutionary biology and in many other disciplines. However, recent research has revealed that the so-called ‘Weismann Barrier’ is leaky, and that information is transferred from soma to germline. Moreover, the germline itself is now known to age, and to be influenced by an age-related deterioration of the soma that houses and protects it. This could reduce the likelihood of successful reproduction by old individuals, but also lead to long-term deleterious consequences for any offspring that they do produce (including a shortened lifespan). Here, we review the evidence from a diverse and multidisciplinary literature for senescence in the germline and its consequences; we also examine the underlying mechanisms responsible, emphasizing changes in mutation rate, telomere loss, and impaired mitochondrial function in gametes. We consider the effect on life-history evolution, particularly reproductive scheduling and mate choice. Throughout, we draw attention to unresolved issues, new questions to consider, and areas where more research is needed. We also highlight the need for a more comparative approach that would reveal the diversity of processes that organisms have evolved to slow or halt age-related germline deterioration.

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“…For example, in humans sperm telomeres increase with age, [ 60 ] but oocyte telomeres do not change. [ 58 ] In mice, sperm telomeres have been reported to both increase [ 91 ] and decrease [ 92 ] with age, and oocyte telomeres decline with age. [ 58 ] However, the influence of parental age on gamete telomeres has seldom been investigated.…”

Section: Factors That May Affect the Relationship Between Parental Agmentioning

confidence: 99%

Cross‐Generational Effects of Parental Age on Offspring Longevity: Are Telomeres an Important Underlying Mechanism?

Heidinger

Young

2020

BioEssays

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Parental age at offspring conception often influences offspring longevity, but the mechanisms underlying this link are poorly understood. One mechanism that may be important is telomeres, highly conserved, repetitive sections of non‐coding DNA that form protective caps at chromosome ends and are often positively associated with longevity. Here, the potential pathways by which the age of the parents at the time of conception may impact offspring telomeres are described first, including direct effects on parental gamete telomeres and indirect effects on offspring telomere loss during pre‐ or post‐natal development. Then a surge of recent studies demonstrating the effects of parental age on offspring telomeres in diverse taxa are reviewed. In doing so, important areas for future research and experimental approaches that will enhance the understanding of how and when these effects likely occur are highlighted. It is concluded by considering the potential evolutionary consequences of parental age on offspring telomeres.

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Longitudinal analysis of somatic and germ‐cell telomere dynamics in outbred mice

Cited by 9 publications

References 69 publications

Impact of Oxidative Stress on Age-Associated Decline in Oocyte Developmental Competence

Impact of Oxidative Stress on Age-Associated Decline in Oocyte Developmental Competence

The deteriorating soma and the indispensable germline: gamete senescence and offspring fitness

Cross‐Generational Effects of Parental Age on Offspring Longevity: Are Telomeres an Important Underlying Mechanism?

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