Longitudinal analysis of serum cystatin C for estimating the glomerular filtration rate in preterm infants

Nakashima, Tsunehiko; Inoue, Hirosuke; Fujiyoshi, Junko; Matsumoto, Naoko

doi:10.1007/s00467-015-3309-x

Cited by 20 publications

(18 citation statements)

References 33 publications

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“…Recent research suggests that CysC levels are independent of birth weight and gestational age. 3,18,24,25 In this study, with larger samples, we confirmed that CysC is independent of BW and GA in newborns, at least within 3 days after birth (p > 0.05).…”

Section: Discussionsupporting

confidence: 71%

Gestational and Age-Specific Cystatin C Reference Intervals for Newborns

Tong

et al. 2021

Am J Perinatol

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Objective Cystatin C (CysC) references are useful for the monitoring of renal function in neonates. However, the standard CysC references in newborn infants have not been determined. The aim of this study was to establish a useful reference range for CysC in newborns. Study Design Serum CysC levels were measured in 1,919 blood samples from 1,044 newborns during their first 28 days of life. CysC levels were analyzed for associations between subgroups dichotomized by postnatal age (PA) and gestational age (GA). The serum CysC reference intervals were determined according to the PA and GA. The associations between the serum CysC level and other biochemical parameters as well as perinatal factors were also analyzed. Results In this study, the mean GA was 35.8 ± 2.9 weeks and the birth weight (BW) was 2,614 ± 697 g. Reference ranges of serum CysC were determined, and a general decreasing trend of CysC levels was observed as the GA increased. CysC levels differed significantly among the PA and GA categories (p < 0.001). Serum CysC levels were relatively stable throughout the GA range but were impacted by the white blood cell count within the first postnatal 24 hours. Moreover, CysC levels always correlated positively with serum creatinine concentrations (p < 0.001). Serum Cr levels were influenced by multiple factors, including BW, GA, total bilirubin, direct bilirubin, white blood cell count, C-reactive protein, and blood urea nitrogen. Conclusion Reference levels of serum CysC should be determined according to the PA and GA. In contrast to Cr, serum CysC is a reliable index for assessing renal function in neonates as it is influenced by very few factors. The CysC reference levels will allow neonatologists to accurately evaluate renal function in the neonatal population. Key Points

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Section: Discussionsupporting

confidence: 71%

Gestational and Age-Specific Cystatin C Reference Intervals for Newborns

Tong

et al. 2021

Am J Perinatol

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“…The available literatures have shown that CysC is independent of birth weight and gestational age [3,24,25,19]. In this study, with larger samples, we further confirmed CysC is independent of BW and GA in newborn, at least within 3 days after birth (P>0.01).…”

Section: (Show In Table 2)supporting

confidence: 83%

Gestational and age-specific cystatin C reference intervals for newborns in China

Tong

et al. 2019

Preprint

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Backgroud : To establish reference values of serum cystatin C (CysC) in Chinese newborn infants.Methods: Serum CysC levels were measured in 1919 blood samples from 1044 newborns during their first 28 days of life. CysC levels were analyzed for association between subgroups dichotomized by postnatal age (PA) and gestational age (GA). Reference intervals of serum CysC were determined according to the PA and GA. The association between serum CysC level and other biochemical parameters as well as perinatal factors were also analyzed.Results: In this study, the mean GA was 35.75±2.90 weeks and birth weight was 2613.77±696.72 g.Reference ranges of serum CysC were determined and a general decreasing trend of CysC levels was observed as GA increased. CysC levels differed significantly among the PA and GA groups (P 0.001).Serum CysC levels were relatively stable throughout GA, except being impacted by white blood cell count within postnatal 24 hours. Moreover, their levels always correlated positively with serum creatinine concentrations (P<0.001).Conclusion: The reference level of serum CysC should be determined according to PA and GA. In contrast to creatinine, serum CysC is a dependable index for assessing renal function in neonate, for there are rare factors influencing it.

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“…18 As for preterm infants, the Cys-C level varied widely in previous reports. 22,23 With regards to this issue Kandasamy et al once summarised a related systematic review, and found the Cys-C level of neonates fluctuates between 1.00 and 2.52 mg/L in different researches. 24 In our opinion, the inconsistent data was mainly caused by different grouping methods, different sample sizes, the interference of diseases and so on.…”

Section: Discussionmentioning

confidence: 99%

Reference values for serum cystatin C in very low‐birthweight infants: From two centres of China

Yang

Pan

et al. 2017

J Paediatrics Child Health

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Longitudinal analysis of serum cystatin C for estimating the glomerular filtration rate in preterm infants

Abstract: Reference ranges for Cys-C in premature infants decline gradually over the first year after birth. Cys-C appears to be a more reliable marker than Cre for estimating GFR in preterm infants.

Cited by 20 publications

References 33 publications

Gestational and Age-Specific Cystatin C Reference Intervals for Newborns

Gestational and Age-Specific Cystatin C Reference Intervals for Newborns

Gestational and age-specific cystatin C reference intervals for newborns in China

Reference values for serum cystatin C in very low‐birthweight infants: From two centres of China

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