Longitudinal analysis of haplotypes and polymorphisms of the APOA5 and APOC3 genes associated with variation in serum triglyceride levels: the Bogalusa Heart Study

Hallman, David; Srinivasan, Sathanur R.; Chen, Wei; Boerwinkle, Eric; Berenson, Gerald S.

doi:10.1016/j.metabol.2006.07.018

Cited by 33 publications

(34 citation statements)

References 37 publications

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“…In this study, the TG levels did not differ between the genotypes of the APOC3 3238C>G SNP, which is inconsistent with results of previous studies in a Tehranian and an Indian population [24,32]; other studies have indicated that this association was found to be either independent of other polymorphisms in the APOC3/APOA5 region [33] or dependent on them [34]. …”

Section: Discussioncontrasting

confidence: 99%

Western Dietary Pattern Interaction with APOC3 Polymorphism in the Risk of Metabolic Syndrome: Tehran Lipid and Glucose Study

Hosseini-Esfahani

Mirmiran²,

Daneshpour³

et al. 2014

Lifestyle Genomics

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Background/Aims: Gene-dietary pattern interactions may contribute to the determination of a susceptibility to metabolic syndrome (MetS). The aim of this study was to evaluate the potential interactions of dietary patterns with the common genetic variant of APOC3 in relation to MetS in adults. Methods: In this individual matched nested case-control study, 755 MetS subjects and 755 controls were selected from among participants in the Tehran Lipid and Glucose Study. Dietary patterns were determined by factor analysis. APOC3 3238C>G rs5128 was genotyped by polymerase chain reaction and restriction fragment length polymorphism. Results: Fat-sweet, healthy and Western dietary patterns (WDP) were extracted from the data. In the joint analysis, the associations of the WDP and APOC3 rs5128 with MetS risk tended to be dependent on APOC3 3238C>G gene variants (p for interaction = 0.009) in women. The MetS risk was increased in women with the CC genotype with increasing tertiles of WDP scores compared with women with the CG + GG genotype, whose MetS risk was decreased with increasing tertiles of WDP scores. In addition, we found that intakes of fast food, salty snacks and soft drinks showed significant interactions with the rs5128 genotypes in relation to MetS risk (p for interactions <0.05). Conclusion: The results obtained demonstrate a diet-gene interaction between APOC3 rs5128 polymorphism and the WDP in relation to MetS risk.

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Section: Discussioncontrasting

confidence: 99%

Western Dietary Pattern Interaction with APOC3 Polymorphism in the Risk of Metabolic Syndrome: Tehran Lipid and Glucose Study

Hosseini-Esfahani

Mirmiran²,

Daneshpour³

et al. 2014

Lifestyle Genomics

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“…Based on population-based studies, there is an association between the level of TG and the ApoAI-CIII-AIV gene cluster in individuals with hyper triglyceridemia [5]. Increasing the level of TG is a major independent risk factor for CAD across populations from America [6,7], Europe [8,9], and Asia [10,11]. In addition, there are other studies assessing the association between ApoE and ApoB gene polymorphisms with lipid levels in Iranians [12], and they show that this population has an inherent tendency for dyslipidemia associated with high risk of CAD [12,13].…”

Section: Introductionmentioning

confidence: 99%

Haplotype analysis of Apo AI-CIII-AIV gene cluster and lipids level: Tehran lipid and glucose study

et al. 2011

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Iranian populations show an increased tendency for abnormal lipid levels and high risk of Coronary artery disease. Considering the important role played by the ApoAI-CIII-AIV gene cluster in the regulation of the level and metabolism of lipids, this study aimed at elucidating the association between five single nucleotide polymorphisms on the Apo11q cluster gene and lipid levels. A cross-sectional study of 823 subjects (340 males and 483 females) from the Tehran lipid and glucose study (TLGS) was conducted. Levels of TG, Chol, HDL-C, Apo AI, Apo AIV, Apo B, and Apo CIII were measured, and the selected segments of the APOAI-CIII-AIV gene cluster were amplified by PCR and the polymorphisms were revealed by RFLP using restriction enzymes. The allele frequencies for each SNP between males and females were not significantly different. The distribution of Genotypes and alleles was in Hardy-Weinberg equilibrium except for Apo AI (+83C>T). The results showed a significant association between TG, HDL-C, HDL(2), Apo AI, and Apo B levels and the presence of some alleles in the polymorphisms studied. After haplotype analysis not only did the association between these variables and SNPs remain but also levels of Chol and LDL-C were added. This study demonstrates that the level of lipids such as TG, HDL-C, HDL(2), Apo AI, and Apo B, maybe regulated partly by genetic factors and their haplotype within the Apo11q gene cluster.

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“…19 Among these, APOCIII and the recently identified APOA5 genes have a regulatory role in triglyceride metabolism. [20][21][22] APOA5 influences the triglyceride metabolism by 2 possible mechanisms: (1) enhancing intravascular triglyceride hydrolysis by activating the lipoprotein lipase, and (2) decreasing the serum concentration of triglycerides through inhibition of hepatic very-low-density lipoprotein-triglyceride production. 23,24 Polymorphisms of APOA5 can influence the function of the protein transcript, which can modify secondarily the interaction of APOA5 with the lipoprotein lipase and result ultimately in increased circulating triglyceride levels.…”

Section: Discussionmentioning

confidence: 99%

Apolipoprotein A5 Gene IVS3+G476A Allelic Variant Confers Susceptibility for Development of Ischemic Stroke

Maász

Kisfali

Járomi

et al. 2008

Circ J

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troke is an acute temporary, or often permanent damage of the brain. In industrialized countries stroke is the third leading cause of death after cardiovascular disorders and malignant tumors. 1 It can affect both sexes at any time of life; however, it is more prevalent in males and people over 50 years of age. Ischemic stroke results in local dysfunction of the brain and comprises 80% of cases. 2 Ischemic stroke can be unequivocally attributed to numerous classic clinical and environmental risk factors, such as diabetes mellitus, hypertension, smoking and excessive alcohol or drug consumption. 3 The role of several factors in the development of the disease is still the subject of investigations, including the possible significance of increased triglyceride levels. In the past decade numerous genetic susceptibility factors have been verified, which alone or in combination with other genes or exogenous factors can have a role in the development of stroke. [4][5][6][7] The apolipoprotein A5 (APOA5) gene is located nearby the APOAI-APOCIII-APOAIV cluster in the 11q23 chroCirculation Journal Vol.72, July 2008 mosome. It includes 3 exons and encodes 366 amino acids. The mature APOA5 protein is synthesized by the liver and secreted into the plasma where it plays a crucial regulatory role in triglyceride metabolism. 8,9 All of the most frequently occurring variants, T-1131C, T1259C, C56G, IVS3+G476A, have been reported as associated with elevated triglyceride levels, and some of them were also found to be independent risk factors for cardio-and cerebrovascular diseases. [10][11][12] Albeit limited data are available about the role of the T1259C and IVS3+G476A variants in triglyceride metabolism, 11,13 their possible significance in stroke has not been examined at all. We have demonstrated that the T-1131C variant confers susceptibility for ischemic stroke, 14 so as a natural extension, the goal of the present study was to investigate the possible pathogenic role of the 1259C and IVS3+476A allelic variants, and the T-1131C variant was also tested in the study population. Methods Study PopulationA total of 378 Caucasian unrelated patients (150 males, 228 females; mean age: 66.1±0.74 years, range: 24-95) with ischemic stroke were enrolled. All of them underwent extended clinical assessment, including general physical and laboratory cardiological and neurological examinations, and past medical and familial histories. After receiving the magnetic resonance imaging (MRI) and clinical neurological results the 378 patients were allocated to 1 of 3 stroke subgroups as previously described. 14 The first group had

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Longitudinal analysis of haplotypes and polymorphisms of the APOA5 and APOC3 genes associated with variation in serum triglyceride levels: the Bogalusa Heart Study

Cited by 33 publications

References 37 publications

Western Dietary Pattern Interaction with APOC3 Polymorphism in the Risk of Metabolic Syndrome: Tehran Lipid and Glucose Study

Western Dietary Pattern Interaction with APOC3 Polymorphism in the Risk of Metabolic Syndrome: Tehran Lipid and Glucose Study

Haplotype analysis of Apo AI-CIII-AIV gene cluster and lipids level: Tehran lipid and glucose study

Apolipoprotein A5 Gene IVS3+G476A Allelic Variant Confers Susceptibility for Development of Ischemic Stroke

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