Longitudinal analysis left ventricular chamber responses under durable LVAD support

Gunawan, Aaron; Robson, Desiree; Krishnaswamy, Rohan J.; Ramanayake, Anju; Kearney, Katherine; Muthiah, Kavitha; Jain, Pankaj; Adji, Audrey; Hayward, Christopher S.

doi:10.1016/j.healun.2023.10.004

The Journal of Heart and Lung Transplantation

2024

DOI: 10.1016/j.healun.2023.10.004

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Longitudinal analysis left ventricular chamber responses under durable LVAD support

Aaron Gunawan,

Desiree Robson,

Rohan J. Krishnaswamy

et al.

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2024

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Preoperative anatomical landmarks and longitudinal HeartMate 3 pump position in X‐rays: Relevance for adverse events

Widhalm,

Aigner,

Gruber

et al. 2024

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BackgroundLeft ventricular assist device (LVAD) malposition has been linked to hemocompatibility‐related adverse events (HRAEs). This study aimed to identify preoperative anatomical landmarks and postoperative pump position, associated with HRAEs during LVAD support.MethodsPre‐ and postoperative chest X‐ray measures (≤14 days pre‐implantation, first postoperative standing, 6, 12, 18, and 24 months post‐implantation) were analyzed for their association with HRAEs over 24 months in 33 HeartMate 3 (HM3) patients (15.2% female, age 66 (9.5) years).ResultsHM3 patients with any HRAE showed significantly lower preoperative distances between left ventricle and thoracic outline (dLVT) (25.3 ± 10.2 mm vs. 40.3 ± 15.5 mm, p = 0.004). A ROC‐derived cutoff dLVT ≤ 29.2 mm provided 85.7% sensitivity and 72.2% specificity predicting any HRAE during HM3 support (76.2% (>29.2 mm) vs. 16.7% (≤29.2 mm) freedom from HRAE, p < 0.001) and significant differences in cardiothoracic ratio (0.58 ± 0.04 vs. 0.62 ± 0.04, p = 0.045). Postoperative X‐rays indicated lower pump depths in patients with ischemic strokes (9.1 ± 16.2 mm vs. 38.0 ± 18.5 mm, p = 0.007), reduced freedom from any neurological event (pump depth ≤ 28.7 mm: 45.5% vs. 94.1%, p = 0.004), and a significant correlation between pump depth and inflow cannula angle (r = 0.66, p < 0.001). Longitudinal changes were observed in heart‐pump width (F(4,60) = 5.61, p < 0.001).ConclusionPreoperative X‐ray markers are associated with postoperative HRAE occurrence. Applying this knowledge in clinical practice may enhance risk stratification, guide therapy optimization, and improve HM3 recipient management.

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Preoperative anatomical landmarks and longitudinal HeartMate 3 pump position in X‐rays: Relevance for adverse events

Widhalm,

Aigner,

Gruber

et al. 2024

Artificial Organs

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show abstract

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Longitudinal analysis left ventricular chamber responses under durable LVAD support

Cited by 1 publication

References 37 publications

Preoperative anatomical landmarks and longitudinal HeartMate 3 pump position in X‐rays: Relevance for adverse events

Preoperative anatomical landmarks and longitudinal HeartMate 3 pump position in X‐rays: Relevance for adverse events

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