“…One observation is that chronic age-related pathologies heavily remodel the ECM during disease development and progression [280]. Not so surprising is that interventions that slow aging and prevent chronic diseases also rebalance pathological ECM remodeling [280]. Interestingly, analyzing chromatin immunoprecipitation (ChIP) sequencing and transcriptomic data, we found that the 12 most established longevity-promoting transcription factors (i.e., CREB1, FOXO1,3, GATA1,2,3,4, HIF1A, JUN, KLF4, MYC, NFE2L2/Nrf2, RELA/NF-κB, REST, STAT3,5A, and TP53/p53), directly and indirectly transcriptionally regulate ECM genes [280].…”