Longevity-associated mitochondrial DNA 5178 C/A polymorphism is associated with fasting plasma glucose levels and glucose tolerance in Japanese men

Kokaze, Akatsuki; Ishikawa, Mamoru; Matsunaga, Naomi; Yoshida, Masao; Makita, Ryuji; Satoh, Masao; Teruya, Koji; Sekiguchi, Kanako; Masuda, Yumi; Harada, Matsuko; Uchida, Yoshiko; Takashima, Yutaka

doi:10.1016/j.mito.2005.09.001

Cited by 16 publications

(16 citation statements)

References 25 publications

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“…This polymorphism is, thus, pathologically, biophysically, and biochemically associated with overall health. Longevity-associated ND2-237 Leu/Met polymorphism reportedly influences the effects of alcohol consumption on blood pressure (Kokaze et al 2004), serum TG levels (Kokaze et al 2003), FPG levels, and response to 75-g-OGTT (Kokaze et al 2005), and, as shown in this paper, SUA levels. The amino acid change from leucine to methionine at residue 237 of NADH dehydrogenase subunit-2 may bring about a functional change to NADH dehydrogenase.…”

Section: Discussionsupporting

confidence: 56%

“…Non-daily drinkers were defined as those who consume alcohol one or more times per week but not every day, those who consume alcohol less once per week, or non-/ex-drinkers. Bonferroni correction for multiple comparisons was applied *P < 0.05 versus non-daily drinkers with ND2-237Leu J Hum Genet (2006) 51:765-771 769 tolerance (Kokaze et al 2005) in healthy Japanese people. This polymorphism is, thus, pathologically, biophysically, and biochemically associated with overall health.…”

Section: Discussionmentioning

confidence: 99%

“…Moreover, genetic epidemiological research has shown that alcohol dehydrogenase 2 (ADH2) genotype (Hashimoto et al 2002) or endothelial constitutive nitric oxide synthase (ecNOS) genotype (Nishio et al 2005) influences the effects of alcohol consumption on serum uric acid (SUA) levels in the Japanese male population. We previously reported the interaction between ND2-237 Leu/Met polymorphism and daily alcohol intake on blood pressure (Kokaze et al 2004), serum triglyceride (TG) levels (Kokaze et al 2003), and fasting plasma glucose (FPG) levels and response to 75-g oral glucose tolerance tests (75-g-OGTT) (Kokaze et al 2005) in healthy Japanese men. To our knowledge, there have been no reports regarding the association between longevityassociated ND2-237 Leu/Met polymorphism and SUA levels, or the effect of ND2-237 Leu/Met polymorphism and drinking frequency on SUA levels.…”

Section: Introductionmentioning

confidence: 99%

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Longevity-associated NADH dehydrogenase subunit-2 237 Leu/Met polymorphism influences the effects of alcohol consumption on serum uric acid levels in nonobese Japanese men

et al. 2006

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NADH dehydrogenase subunit-2 237 leucine/methionine (ND2-237 Leu/Met) polymorphism is reportedly associated with longevity in the Japanese population. The ND2-237Met genotype may confer resistance to cardiovascular and cerebrovascular atherogenic diseases. Hyperuricemia is one of the risk factors for cardiovascular disease. To investigate whether ND2-237 Leu/Met polymorphism is associated with serum uric acid (SUA) levels, we conducted a cross-sectional study in 321 healthy Japanese male subjects. In nonobese (body mass index, BMI < 25) male subjects, interaction between ND2-237 Leu/Met genotypes and drinking frequency on SUA levels was observed (P=0.031). The SUA levels were significantly higher in daily drinkers with ND2-237Leu than in non-daily drinkers with ND2-237Leu (P=0.018). In nonobese men, after adjustment for covariates, daily drinkers with ND2-237Leu had a significantly higher odds ratio (OR) for hyperuricemia (SUA ‡6.5 mg/dl: vs. daily drinkers with ND2-237Met, OR=3.26, 95% confidence interval (CI) 1.14-9.29; vs. non-daily drinkers with ND2-237Leu, OR=3.22, 95% CI 1.39-7.45; SUA ‡7.0 mg/dl: vs. non-daily drinkers with ND2-237Met, OR=3.53, 95% CI 1.00-12.4). However, in obese (BMI ‡25) men, no significant interaction between ND2-237 Leu/Met polymorphism and habitual drinking on SUA levels or on the risk for hyperuricemia was observed. These results suggest that ND2-237 Leu/Met polymorphism modulates the effects of daily alcohol consumption on SUA levels in nonobese Japanese men.

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Section: Discussionsupporting

confidence: 56%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Longevity-associated NADH dehydrogenase subunit-2 237 Leu/Met polymorphism influences the effects of alcohol consumption on serum uric acid levels in nonobese Japanese men

et al. 2006

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“…14 This polymorphism is reportedly associated with serum lipid levels 15 and fasting plasma glucose levels. 16 Moreover, the Mt5178 C/A polymorphism modulates the effects of alcohol consumption on blood pressure, 17 risk of hypertension, 10 serum triglyceride levels, 18 yearly changes in serum low-density lipoprotein (LDL) cholesterol levels 19 and serum uric acid levels. 20 Previous studies have also reported the combined effects of the Mt5178 C/A polymorphism and coffee consumption on the risk of hypertension 21 or abnormal glucose tolerance 22 in middle-aged Japanese men.…”

Section: Introductionmentioning

confidence: 99%

Combined effect of longevity-associated mitochondrial DNA 5178 C/A polymorphism and coffee consumption on the risk of hyper-LDL cholesterolemia in middle-aged Japanese men

et al. 2010

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The objective of this study was to investigate whether the mitochondrial DNA 5178 cytosine/adenine (Mt5178 C/A) polymorphism modifies the effects of coffee consumption on serum lipid levels and the risk of dyslipidemia in middle-aged Japanese men. A total of 397 male subjects (age, 53.9±7.8 years; mean±s.d.) were selected from among individuals visiting the hospital for regular medical check-ups. After adjustment for age, body mass index, habitual alcohol consumption, habitual smoking and use of antihypertensive medication, among subjects who consumed o1 cup of coffee per day, the odds ratio (OR) for hyper-low-density lipoprotein (LDL) cholesterolemia (serum LDL cholesterol X140 mg per 100 ml) was significantly lower in those with Mt5178A than in those with Mt5178C (OR¼0.378, 95% confidence interval: 0.153-0.919). After adjustment, the association between the Mt5178A genotype and hyper-LDL cholesterolemia depended on coffee consumption (P for trend¼0.018). Coffee consumption was positively associated with serum LDL cholesterol levels only in subjects with Mt5178A. However, in subjects with Mt5178C, serum LDL cholesterol level or risk of hyper-LDL cholesterolemia did not seem to depend on coffee consumption. These results suggest that for men with Mt5178A, coffee consumption negates the genetic benefit of lower risk for hyper-LDL cholesterolemia.

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“…The frequency of the Mt5178A genotype, a genetic marker of mitochondrial haplogroup D, is significantly higher in Japanese centenarians than in the general population (Alexe et al 2007;Tanaka et al 1998) and it is reported that individuals with Mt5178A (mitochondrial haplogroup D) are less susceptible to lifestyle-related adult-onset diseases, for example hypertension (Kokaze et al 2007), diabetes (Wang et al 2001), metabolic syndrome ), myocardial infarction (Mukae et al 2003;Takagi et al 2004), and cerebrovascular diseases (Ohkubo et al 2002), than those with Mt5178C. Mt5178 C/A polymorphism is, moreover, also reported to be associated with blood pressure (Kokaze et al 2004a(Kokaze et al , 2007, serum lipid levels (Kokaze et al 2001(Kokaze et al , 2003a, fasting plasma glucose levels and glucose tolerance (Kokaze et al 2005a), serum uric acid levels (Kokaze et al 2006), intraocular pressure (Kokaze et al 2004b), hematological data (Kokaze et al 2005b), and serum protein fraction levels (Kokaze et al 2002(Kokaze et al , 2003b, and its interaction with smoking habits is associated with serum triglyceride levels (Kokaze et al 2003a), intraocular pressure (Kokaze et al 2004b), red blood cell counts (Kokaze et al 2005b), and serum protein fraction levels (Kokaze et al 2003b). As far as we are aware, however, no information is available about the relationship between Mt5178 C/A polymorphism and respiratory function or about its interaction with smoking habits in respiratory function.…”

Section: Introductionmentioning

confidence: 99%

Longevity-associated mitochondrial DNA 5178 C/A polymorphism and its interaction with cigarette consumption are associated with pulmonary function in middle-aged Japanese men

et al. 2007

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Pulmonary function is a crucial factor associated with longevity. Mitochondrial DNA 5178 cytosine/ adenine (Mt5178 C/A) polymorphism is reported to be associated with longevity in the Japanese population. We have previously reported that Mt5178 C/A polymorphism is widely associated with physiological and biochemical status. The objective of this study was to investigate whether Mt5178 C/A polymorphism is associated with pulmonary function. The subjects were 463 Japanese men (mean age ± SD 54.0 ± 7.6 years). Genotyping of Mt5178 C/A was performed by polymerase chain reaction-restriction fragment length polymorphism. A cross-sectional study of the relationship between genotype and spirometric data, namely forced vital capacity (FVC) and forced expiratory volume in 1 s (FEV 1 ), was conducted. Among younger subjects (age <55 years), FVC and FEV 1 were significantly higher for men with Mt5178A than for those with Mt5178C. Interaction between Mt5178 C/A polymorphism and smoking habits in FEV 1 /FVC ratio was observed. Cigarette consumption (pack-years of smoking) was significantly and negatively associated with FEV 1 / FVC ratio for men with Mt5178C. Among older subjects (age ‡55 years), FEV 1 /FVC ratio was significantly lower for current smokers with Mt5178C than for never smokers with Mt5178C or for never smokers with Mt5178A. Mt5178 C/A polymorphism and its interaction with cigarette consumption may be associated with pulmonary function in Japanese men.

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Longevity-associated mitochondrial DNA 5178 C/A polymorphism is associated with fasting plasma glucose levels and glucose tolerance in Japanese men

Cited by 16 publications

References 25 publications

Longevity-associated NADH dehydrogenase subunit-2 237 Leu/Met polymorphism influences the effects of alcohol consumption on serum uric acid levels in nonobese Japanese men

Longevity-associated NADH dehydrogenase subunit-2 237 Leu/Met polymorphism influences the effects of alcohol consumption on serum uric acid levels in nonobese Japanese men

Combined effect of longevity-associated mitochondrial DNA 5178 C/A polymorphism and coffee consumption on the risk of hyper-LDL cholesterolemia in middle-aged Japanese men

Longevity-associated mitochondrial DNA 5178 C/A polymorphism and its interaction with cigarette consumption are associated with pulmonary function in middle-aged Japanese men

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