Longevity-associated mitochondrial DNA 5178 A/C polymorphism influences effects of cigarette smoking on serum protein fraction levels in Japanese men

Kokaze, Akatsuki; Ishikawa, Mamoru; Matsunaga, Naomi; Yoshida, Masao; Sekine, Yasuko; Sekiguchi, Kanako; Satoh, Masao; Harada, Matsuko; Teruya, Koji; Takeda, Nobuo; Uchida, Yoshiko; Takashima, Yutaka

doi:10.1016/s0047-6374(03)00110-6

Cited by 13 publications

(14 citation statements)

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“…We have discovered gene-environment interactions between Mt5178 C/A polymorphism and smoking habits for serum triglyceride levels (Kokaze et al 2003a), intraocular pressure (Kokaze et al 2004b), hematological data (Kokaze et al 2005b), serum protein fraction levels (Kokaze et al 2003b), and, in this study, FEV 1 /FVC ratio. The precise mechanisms through which Mt5178 C/A polymorphism exerts its interaction with habitual smoking, and thereby affects biophysical and biochemical status, are unknown.…”

Section: Discussionmentioning

confidence: 60%

“…The frequency of the Mt5178A genotype, a genetic marker of mitochondrial haplogroup D, is significantly higher in Japanese centenarians than in the general population (Alexe et al 2007;Tanaka et al 1998) and it is reported that individuals with Mt5178A (mitochondrial haplogroup D) are less susceptible to lifestyle-related adult-onset diseases, for example hypertension (Kokaze et al 2007), diabetes (Wang et al 2001), metabolic syndrome ), myocardial infarction (Mukae et al 2003;Takagi et al 2004), and cerebrovascular diseases (Ohkubo et al 2002), than those with Mt5178C. Mt5178 C/A polymorphism is, moreover, also reported to be associated with blood pressure (Kokaze et al 2004a(Kokaze et al , 2007, serum lipid levels (Kokaze et al 2001(Kokaze et al , 2003a, fasting plasma glucose levels and glucose tolerance (Kokaze et al 2005a), serum uric acid levels (Kokaze et al 2006), intraocular pressure (Kokaze et al 2004b), hematological data (Kokaze et al 2005b), and serum protein fraction levels (Kokaze et al 2002(Kokaze et al , 2003b, and its interaction with smoking habits is associated with serum triglyceride levels (Kokaze et al 2003a), intraocular pressure (Kokaze et al 2004b), red blood cell counts (Kokaze et al 2005b), and serum protein fraction levels (Kokaze et al 2003b). As far as we are aware, however, no information is available about the relationship between Mt5178 C/A polymorphism and respiratory function or about its interaction with smoking habits in respiratory function.…”

Section: Introductionmentioning

confidence: 99%

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Longevity-associated mitochondrial DNA 5178 C/A polymorphism and its interaction with cigarette consumption are associated with pulmonary function in middle-aged Japanese men

et al. 2007

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Pulmonary function is a crucial factor associated with longevity. Mitochondrial DNA 5178 cytosine/ adenine (Mt5178 C/A) polymorphism is reported to be associated with longevity in the Japanese population. We have previously reported that Mt5178 C/A polymorphism is widely associated with physiological and biochemical status. The objective of this study was to investigate whether Mt5178 C/A polymorphism is associated with pulmonary function. The subjects were 463 Japanese men (mean age ± SD 54.0 ± 7.6 years). Genotyping of Mt5178 C/A was performed by polymerase chain reaction-restriction fragment length polymorphism. A cross-sectional study of the relationship between genotype and spirometric data, namely forced vital capacity (FVC) and forced expiratory volume in 1 s (FEV 1 ), was conducted. Among younger subjects (age <55 years), FVC and FEV 1 were significantly higher for men with Mt5178A than for those with Mt5178C. Interaction between Mt5178 C/A polymorphism and smoking habits in FEV 1 /FVC ratio was observed. Cigarette consumption (pack-years of smoking) was significantly and negatively associated with FEV 1 / FVC ratio for men with Mt5178C. Among older subjects (age ‡55 years), FEV 1 /FVC ratio was significantly lower for current smokers with Mt5178C than for never smokers with Mt5178C or for never smokers with Mt5178A. Mt5178 C/A polymorphism and its interaction with cigarette consumption may be associated with pulmonary function in Japanese men.

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Section: Discussionmentioning

confidence: 60%

Section: Introductionmentioning

confidence: 99%

Longevity-associated mitochondrial DNA 5178 C/A polymorphism and its interaction with cigarette consumption are associated with pulmonary function in middle-aged Japanese men

et al. 2007

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“…Kokaze and colleagues18 reported that serum concentrations of high‐density lipoprotein (HDL) cholesterol were significantly higher in men carrying 5178A than in those carrying 5178C and that serum concentrations of triglycerides (TG) were significantly lower in women carrying 5178A than in those carrying 5178C, suggesting that the antiatherogenic effect of Mt5178A may be in part attributable to favorable lipid metabolism. Kokaze and colleagues19 examined whether Mt5178 A/C polymorphism influenced the effects of habitual smoking on serum protein fraction levels in 321 healthy Japanese men. In Mt5178C genotype men, alpha‐1 and alpha‐2 globulin levels were higher in smokers than in nonsmokers, whereas in Mt5178A genotype men no significant difference was observed in alpha‐1 or alpha‐2 globulin levels between smokers and nonsmokers.…”

Section: Characteristics and Phenotypes Of Mitochondrial Haplogroupsmentioning

confidence: 99%

Mitochondrial Genome Single Nucleotide Polymorphisms and Their Phenotypes in the Japanese

Tanaka¹,

Takeyasu²,

Fuku³

et al. 2004

Annals of the New York Academy of Sciences

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Polymorphisms in the human mitochondrial genome have been used for the elucidation of phylogenetic relationships among various ethnic groups. Because analysis by mitochondrial genetics has detected pathogenic mutations causing mitochondrial encephalomyopathy or cardiomyopathy, most of the mitochondrial single nucleotide polymorphisms (mtSNPs) found in control subjects have been regarded as merely normal variants. However, we cannot exclude the possibility that the mitochondrial functional differences among individuals are ascribable at least in part to the mtSNPs of each individual. Human lifespan in ancient history was much shorter than that at the present time. Therefore, it is reasonable to speculate that certain mtSNPs that predispose one toward susceptibility to adult- or elderly-onset diseases, such as Parkinson's disease and Alzheimer's disease, have never been a target for natural selection in the past. Similarly, thrifty mtSNPs that had been advantageous for survival under severe famine or cold climate conditions might turn out to be related to satiation-related diseases, such as diabetes mellitus and obesity. To examine these hypotheses, we have constructed a mtSNP database by sequencing the entire mitochondrial genomes of 672 subjects: 96 in each of seven groups (i.e., centenarians, young obese or non-obese subjects, diabetic patients with or without major vascular involvement, patients with Parkinson's disease, and those with Alzheimer's disease).

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“…17 It also modifies the effects of habitual smoking on serum lipid levels, 21 hematological parameters, 23 pulmonary function, 16 intraocular pressure, 17 and serum protein fraction levels. 24 As compared to Japanese with ND2-237Leu, those with ND2-237Met are more resistant to lifestyle-related adult-onset diseases, such as hypertension, 20 diabetes, 25 myocardial infarction, 26 , 27 and cerebrovascular disorders. 28 Primary prevention of hypertension is crucial for the prevention of adult-onset atherosclerotic diseases.…”

Section: Introductionmentioning

confidence: 99%

NADH Dehydrogenase Subunit-2 237 Leu/Met Polymorphism Modulates the Effects of Coffee Consumption on the Risk of Hypertension in Middle-Aged Japanese Men

Kokaze

Ishikawa

Matsunaga

et al. 2009

Journal of Epidemiology

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BackgroundHabitual coffee consumption has been reported to lower blood pressure in the Japanese population. The NADH dehydrogenase subunit-2 237 leucine/methionine (ND2-237 Leu/Met) polymorphism is associated with longevity and modifies the effects of alcohol consumption on blood pressure in the Japanese population. The objective of this study was to determine whether this polymorphism also modifies the effects of coffee consumption on blood pressure or the risk of hypertension in middle-aged Japanese men.MethodsA total of 398 men (mean age ± standard deviation, 53.8 ± 7.8 years) were selected from among individuals visiting the hospital for regular medical check-ups. Hypertension was defined as a systolic blood pressure ≥140 mm Hg, diastolic blood pressure ≥90 mm Hg, or antihypertensive drug treatment. Polymerase chain reaction-restriction fragment length polymorphism using the restriction enzyme AluI was performed to determine ND2-237 Leu/Met genotype.ResultsIn subjects with ND2-237Leu, coffee consumption was significantly and negatively associated with diastolic blood pressure (P = 0.007). The odds ratio (OR) for hypertension was significantly lower in subjects with ND2-237Leu who consumed 2 or 3 cups of coffee per day than in those who consumed less than 1 cup of coffee per day (OR, 0.517; 95% confidence interval [CI], 0.276 to 0.968; P = 0.039). After adjustment, the OR remained significant (OR = 0.399; 95% CI, 0.184 to 0.869; P = 0.020). Moreover, after adjustment, the OR was significantly lower in subjects with ND2-237Leu who consumed more than 4 cups of coffee per day than in those who consumed less than 1 cup of coffee per day (OR, 0.246; 95% CI, 0.062 to 0.975; P = 0.046). However, the association between ND2-237Met genotype and hypertension did not depend on coffee consumption.ConclusionsThe present results suggest that the ND2-237 Leu/Met polymorphism modulates the effects of coffee consumption on hypertension risk in middle-aged Japanese men.

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Longevity-associated mitochondrial DNA 5178 A/C polymorphism influences effects of cigarette smoking on serum protein fraction levels in Japanese men

Cited by 13 publications

References 38 publications

Longevity-associated mitochondrial DNA 5178 C/A polymorphism and its interaction with cigarette consumption are associated with pulmonary function in middle-aged Japanese men

Longevity-associated mitochondrial DNA 5178 C/A polymorphism and its interaction with cigarette consumption are associated with pulmonary function in middle-aged Japanese men

Mitochondrial Genome Single Nucleotide Polymorphisms and Their Phenotypes in the Japanese

NADH Dehydrogenase Subunit-2 237 Leu/Met Polymorphism Modulates the Effects of Coffee Consumption on the Risk of Hypertension in Middle-Aged Japanese Men

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