Longer-term use of electronic cigarettes when provided as a stop smoking aid: Systematic review with meta-analyses

Butler, Ailsa R.; Lindson, Nicola; Fanshawe, Thomas; Theodoulou, Annika; Begh, Rachna; Hájek, Peter; McRobbie, Hayden; Bullen, Chris; Notley, Caitlin; Rigotti, Nancy A.; Hartmann‐Boyce, Jamie

doi:10.1016/j.ypmed.2022.107182

Cited by 23 publications

(10 citation statements)

References 35 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Second, in contrast with short-term use of NRT, e-cigarettes may be continued after the target quit date for smoking . A meta-analysis of studies on long-term use of e-cigarettes as an aid to smoking cessation found that 54% of participants assigned to e-cigarette conditions continued using e-cigarettes at 6 months or longer after randomization, and 70% of participants who had quit cigarettes were still using e-cigarettes at 6 months or longer after randomization. Third, it may take cigarette users some time to adjust to differences in e-cigarette use, such as deeper inhalation and longer puff duration compared with smoking .…”

Section: Discussionmentioning

confidence: 99%

Cigarette Smoking Abstinence Among Pregnant Individuals Using E-Cigarettes or Nicotine Replacement Therapy

Wen,

Chung,

Liszewski

et al. 2023

JAMA Netw Open

View full text Add to dashboard Cite

ImportanceSmoking cigarettes during pregnancy can impair maternal and child health, and pregnant individuals have increasingly used electronic cigarettes (e-cigarettes) for various reasons, including quitting smoking.ObjectiveTo assess smoking abstinence rates among pregnant individuals who used e-cigarettes compared with those who used nicotine replacement therapy (NRT).Design, Setting, and ParticipantsThis cohort study is a secondary data analysis of phase 8 of the US Pregnancy Risk Assessment Monitoring System, conducted between 2016 and 2020. Eligible participants included pregnant individuals who smoked combustible cigarettes within the 3 months before pregnancy and either used e-cigarettes or NRT during pregnancy. Data analysis was conducted from March 2022 to April 2023.ExposuresCombustible cigarette use within 3 months before pregnancy and use of either e-cigarettes or NRT during pregnancy.Main Outcomes and MeasuresThe primary outcome was the individual’s self-reported smoking abstinence status during the last 3 months of pregnancy. Weighted percentages were reported and weighted multivariable logistic regression models were used to examine the association of e-cigarette use vs NRT with smoking abstinence. A propensity score was used to control for confounding by sociodemographics, pregnancy characteristics, prepregnancy smoking intensity, depression, behavioral support, and hookah use.ResultsThe cohort included 1329 pregnant individuals (759 ≥25 years [60.2%]; 766 non-Hispanic White individuals [79.8%]) of whom 781 had an education level of high school or lower (61.4%), and 952 had an annual household income of $48 000 or less (81.5%). Of the 1329 individuals, 890 (unweighted percentage, 67.0%) were existing e-cigarette users, 67 (unweighted percentage, 5.0%) were new e-cigarette users, and 372 (unweighted percentage, 28.0%) were NRT users. Compared with individuals who used NRT during pregnancy, individuals who used e-cigarettes had a higher rate of smoking abstinence in late pregnancy (456 individuals [50.8%] vs 67 individuals [19.4%]; propensity score adjusted odds ratio [OR], 2.47; 95% CI, 1.17-5.20; P = .02). In the secondary analysis stratified by the timing of e-cigarette use initiation, existing users of e-cigarettes who initiated before pregnancy had a higher smoking abstinence rate than NRT users (446 users [53.1%] vs 67 users [19.4%]; adjusted OR, 2.61; 95% CI, 1.23-5.51; P = .01). However, new e-cigarette users who initiated use during pregnancy had a similar smoking abstinence rate in late pregnancy when compared with NRT users (10 users [20.6%] vs 67 users [19.4%]; adjusted OR, 1.13; 95% CI, 0.22-5.87; P = .88).Conclusions and RelevanceThese findings suggest that individuals who used e-cigarettes during pregnancy had a higher smoking abstinence rate in late pregnancy than individuals who used NRT, especially for those who initiated e-cigarette use before pregnancy, indicating that replacement of cigarettes with e-cigarettes during pregnancy may be a viable strategy for harm reduction.

show abstract

Section: Discussionmentioning

confidence: 99%

Cigarette Smoking Abstinence Among Pregnant Individuals Using E-Cigarettes or Nicotine Replacement Therapy

Wen,

Chung,

Liszewski

et al. 2023

JAMA Netw Open

View full text Add to dashboard Cite

show abstract

“…Eine Gesamteinschätzung aller 6 Studien wird nicht berichtet. Jedoch zeigen die Ergebnisse von 2 Metaanalysen, dass Raucher, die laut Studienprotokoll E-Zigaretten erhielten, im Vergleich zu denen, die Nikotinersatzprodukte erhielten, bei der längsten Nachbeobachtungszeit signifikant niedrigere Nikotinabstinenzraten aufwiesen [31,32].…”

Section: E-zigaretten Zur Raucherentwöhnungunclassified

Beabsichtigte und unbeabsichtigte Wirkungen von E-Zigaretten in klinischen Studien – ein Plädoyer für (mehr) Transparenz

Hanewinkel,

Ulbricht

2024

Pneumologie

View full text Add to dashboard Cite

ZusammenfassungE-Zigaretten werden in klinischen Studien zur Tabakentwöhnung eingesetzt. Aufgrund der Gesundheitsrisiken, die mit dem Gebrauch von E-Zigaretten verbunden sind, sollten die Ergebnisse klinischer Studien vollständig berichtet werden, einschließlich des fortgesetzten ausschließlichen Gebrauchs und des gemeinsamen Gebrauchs von Tabak und E-Zigaretten. Die Ergebnisse zur Nikotinentwöhnung sollten als primärer Endpunkt ebenso wie die Analyse der bloßen Beendigung des Tabakkonsums berichtet werden. Da es derzeit keine stichhaltigen Belege dafür gibt, dass die Reduzierung des Zigarettenkonsums wesentliche gesundheitliche Vorteile mit sich bringt, sollte die Reduzierung des Zigarettenkonsums nicht als Gesundheitsendpunkt in klinischen Studien verwendet werden. Die fortbestehende Nikotinabhängigkeit sollte als „unerwünschtes Ereignis“ in die Berichterstattung über die Studienergebnisse aufgenommen werden.

show abstract

“…A large proportion of people randomized to electronic cigarettes continue to use electronic cigarettes in the long term. 20 In fact, the majority of the approximately 10.9 million American adults who currently use electronic cigarettes are either former smokers who report using electronic cigarettes to quit smoking, or current smokers who are using electronic cigarettes to reduce or quit smoking. 21 Moreover, individuals with schizophrenia have been shown to have a biologic basis for nicotine self-medication that worsens their dependence.…”

Section: The Role Of Electronic Cigarettes As a Smoking Cessation Toolmentioning

confidence: 99%

“…29,30 Practically speaking, since many people who use electronic cigarettes to quit smoking tend to continue to use them in the long term, they may be more accurately considered as a harm reduction tool. 20,21 Data above describe acute or short-term effects of electronic cigarettes; and although benefits appear sustained at 6 months of combustible smoking cessation, definite evidence that electronic cigarettes are less harmful must depend on long-term outcome studies-data that do not yet exist.…”

Section: Evidence That Electronic Cigarettes Are Less Harmful Than To...mentioning

confidence: 99%

Electronic Cigarettes: an Overlooked Tool to Alleviate Disparities in Tobacco Use Disorder Among People with Mental Health and Substance Use Disorders

et al. 2023

View full text Add to dashboard Cite

The remarkable decline in cigarette smoking since 1964 has plateaued; approximately 12.5% of Americans still smoke. People who continue to smoke are largely members of marginalized groups, such as people with behavioral health conditions (BHC), encompassing both mental health and substance use disorders. Certified smoking cessation interventions can increase smoking abstinence in trials in people with BHC, yet smoking rates remain markedly increased, leading to increased mortality from smoking-related diseases, and worsening health disparities. A novel approach tailored to the unique needs, characteristics, and circumstances of people with BHC is mandated. One promising approach, the electronic cigarette, has not been embraced in the USA, likely due to an understandable concern for non-smoking young people among whom electronic cigarettes have been popular. Recent data confirm that electronic cigarette use is declining among young people, yet cigarette smoking is not declining among people with BHC. We propose smoking cessation trials utilizing electronic cigarettes in people with BHC. To this goal, the UK has already begun allowing companies to submit their products for approval as medically licensed electronic cigarettes that can be prescribed as smoking cessation aids. Our proposal is timely, backed by evidence, and aims to save hundreds of thousands of American lives.

show abstract

Longer-term use of electronic cigarettes when provided as a stop smoking aid: Systematic review with meta-analyses

Cited by 23 publications

References 35 publications

Cigarette Smoking Abstinence Among Pregnant Individuals Using E-Cigarettes or Nicotine Replacement Therapy

Cigarette Smoking Abstinence Among Pregnant Individuals Using E-Cigarettes or Nicotine Replacement Therapy

Beabsichtigte und unbeabsichtigte Wirkungen von E-Zigaretten in klinischen Studien – ein Plädoyer für (mehr) Transparenz

Electronic Cigarettes: an Overlooked Tool to Alleviate Disparities in Tobacco Use Disorder Among People with Mental Health and Substance Use Disorders

Contact Info

Product

Resources

About