Longer &lt;i&gt;HSD11B2&lt;/i&gt; CA-repeat in impaired glucose tolerance and type 2 diabetes

Mune, Tomoatsu; Suwa, Tetsuya; Morita, Hiroyuki; Isomura, Yukinori; Takada, Nobuki; Yamamoto, Yuhei; Hayashi, Makoto; Yamakita, Noriyoshi; Sasaki, Akihiko; Takeda, Noriyuki; Takeda, Jun; White, Perrin C.; Kaku, Kohei

doi:10.1507/endocrj.ej12-0108

Cited by 8 publications

(7 citation statements)

References 29 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Negative findings were yielded for HSD11B2 SNPs with adolescent obesity (Ruan et al, 2014 ); similarly, gene regulation studies identified only microRNA relevant to renal functioning (Rezaei et al, 2014 ). However, the polymorphic CA-repeat polymorphism in the first intron of HSD11B2 was significantly related to insulin insensitivity (Mune et al, 2013 ).…”

Section: Genomic Foundation Of Basic Regulatory Mechanisms In Metsmentioning

confidence: 99%

Neuroendocrinological and Epigenetic Mechanisms Subserving Autonomic Imbalance and HPA Dysfunction in the Metabolic Syndrome

2016

View full text Add to dashboard Cite

Impact of environmental stress upon pathophysiology of the metabolic syndrome (MetS) has been substantiated by epidemiological, psychophysiological, and endocrinological studies. This review discusses recent advances in the understanding of causative roles of nutritional factors, sympathomedullo-adrenal (SMA) and hypothalamic-pituitary adrenocortical (HPA) axes, and adipose tissue chronic low-grade inflammation processes in MetS. Disturbances in the neuroendocrine systems for leptin, melanocortin, and neuropeptide Y (NPY)/agouti-related protein systems have been found resulting directly in MetS-like conditions. The review identifies candidate risk genes from factors shown critical for the functioning of each of these neuroendocrine signaling cascades. In its meta-analytic part, recent studies in epigenetic modification (histone methylation, acetylation, phosphorylation, ubiquitination) and posttranscriptional gene regulation by microRNAs are evaluated. Several studies suggest modification mechanisms of early life stress (ELS) and diet-induced obesity (DIO) programming in the hypothalamic regions with populations of POMC-expressing neurons. Epigenetic modifications were found in cortisol (here HSD11B1 expression), melanocortin, leptin, NPY, and adiponectin genes. With respect to adiposity genes, epigenetic modifications were documented for fat mass gene cluster APOA1/C3/A4/A5, and the lipolysis gene LIPE. With regard to inflammatory, immune and subcellular metabolism, PPARG, NKBF1, TNFA, TCF7C2, and those genes expressing cytochrome P450 family enzymes involved in steroidogenesis and in hepatic lipoproteins were documented for epigenetic modifications.

show abstract

Section: Genomic Foundation Of Basic Regulatory Mechanisms In Metsmentioning

confidence: 99%

Neuroendocrinological and Epigenetic Mechanisms Subserving Autonomic Imbalance and HPA Dysfunction in the Metabolic Syndrome

2016

View full text Add to dashboard Cite

show abstract

“…For example, the HSD11B2 gene can encode type 2 11β-hydroxysteroid dehydrogenase and participate in intracellular homeostasis, and convert cortisol to cortisone. It is an inactive corticosteroid that can prevent obesity and high blood pressure (Mune et al 2013). In the present study, we found that LRPAP1, a gene related to myopia, was elevated in giant pandas, which provided a new clue for the giant pandas' poor eyesight (Aldahmesh et al 2013).…”

Section: Discussionmentioning

confidence: 55%

Comparative genomics reveals bamboo feeding adaptability in the giant panda (Ailuropoda melanoleuca)

He¹,

Hsu²,

Hou³

et al. 2020

View full text Add to dashboard Cite

The giant panda (Ailuropoda melanoleuca) is one of the world’s most endangered mammals and remains threatened as a result of intense environmental and anthropogenic pressure. The transformation and specialization of the giant panda’s diet into a herbivorous diet have resulted in unique adaptabilities in many aspects of their biology, physiology and behavior. However, little is known about their adaptability at the molecular level. Through comparative analysis of the giant panda’s genome with those of nine other mammalian species, we found some genetic characteristics of the giant panda that can be associated with adaptive changes for effective digestion of plant material. We also found that giant pandas have similar genetic characteristics to carnivores in terms of olfactory perception but have similar genetic characteristics to herbivores in terms of immunity and hydrolytic enzyme activity. Through the analysis of gene family expansion, 3752 gene families were found, which were enriched in functions such as digestion. A total of 93 genes under positive selection were screened out and gene enrichment identified these genes for the following processes: negative regulation of cellular metabolic process, negative regulation of nitrogen compound metabolic process, negative regulation of macromolecule metabolic process and negative regulation of metabolic process. Combined with the KEGG pathway, it was found that genes such as CREB3L1, CYP450 2S1, HSD11B2, LRPAP1 play a key role in digestion. These genes may have played a key role in the pandas’ adaptation to its bamboo diet.

show abstract

“…This polymorphism is much more frequent in the general population and was shown to affect cortisol plasma concentrations [11,16]. The HSD11B2[CA]n microsatellite polymorphism in the first intron is associated with sodium sensitive essential hypertension [11,17], impaired glucose tolerance and type 2 diabetes [16] and birth weight-adolescent blood pressure associations [18]. But polymorphisms in the gene have not been consistently associated with hypertension [11,17,19,20].…”

Section: Discussionmentioning

confidence: 99%

A Functional Fetal HSD11B2[CA]n Microsatellite Polymorphism is Associated with Maternal Serum Cortisol Concentrations in Pregnant Women

Chen

Zi-neng

et al. 2013

Kidney Blood Press Res

View full text Add to dashboard Cite

Background/Aims: Cortisol plays an important role during pregnancy. It controls maternal glucose metabolism and fetal development. Cortisol metabolism is partially controlled by the 11b-HSD2. This enzyme is expressed in the kidney and human placenta. The activity of the enzyme is partially controlled by functional polymorphisms: the HSD11B2[CA]n microsatellite polymorphism. The impact of this functional gene polymorphism on cortisol metabolism and potential effects on the newborn's is unknown so far. Methods: In the current prospective birth cohort study in southern Asia, we analyzed the association of the HSD11B2[CA]n microsatellite polymorphisms in 187 mothers and their newborn's on maternal and newborn's serum cortisol concentrations. Results: Using multivariable regression analyses considering known confounding (gestational age, newborn's gender, the labor uterine contraction states and the timing during the day of blood taking), we showed that the fetal HSD11B2[CA]n microsatellite polymorphisms in the first intron was related to maternal cortisol concentration (R2=0.26, B=96.27, p=0.007), whereas as the newborn's cortisol concentrations were independent of fetal and maternal HSD11B2[CA]n microsatellite polymorphism. Conclusions: Our study showed for the first time that the fetal HSD11B2[CA]n microsatellite polymorphism of the HSD11B2 gene in healthy uncomplicated human pregnancy is associated with maternal cortisol concentration. This indicates that fetal genes controlling cortisol metabolism may affect maternal cortisol concentration and hence physiology in healthy pregnant women.

show abstract

Longer <i>HSD11B2</i> CA-repeat in impaired glucose tolerance and type 2 diabetes

Cited by 8 publications

References 29 publications

Neuroendocrinological and Epigenetic Mechanisms Subserving Autonomic Imbalance and HPA Dysfunction in the Metabolic Syndrome

Neuroendocrinological and Epigenetic Mechanisms Subserving Autonomic Imbalance and HPA Dysfunction in the Metabolic Syndrome

Comparative genomics reveals bamboo feeding adaptability in the giant panda (Ailuropoda melanoleuca)

A Functional Fetal HSD11B2[CA]n Microsatellite Polymorphism is Associated with Maternal Serum Cortisol Concentrations in Pregnant Women

Contact Info

Product

Resources

About