Longer duration of obesity is associated with a reduction in urinary angiotensinogen in prepubertal children

Morato, Manuela; Correia-Costa, Liane; Sousa, Teresa; Cosme, Dina; Schaefer, Franz; Areias, José Carlos; Guerra, António; Afonso, Alberto Caldas; Barros, Henrique; Azevedo, Ana; Albino‐Teixeira, António

doi:10.1007/s00467-017-3639-y

Cited by 3 publications

(3 citation statements)

References 49 publications

(81 reference statements)

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“…We here showed that SCr values of children with overweight and obesity are within the reference range. While some studies have demonstrated similar SCr values between children with lean weight and overweight or obesity [32][33][34][35], in other studies [36,37], SCr values were higher in children with overweight or obesity compared to lean controls. It is not excluded that these inconsistent results are due to confounding factors such as age, height, and sex and/or due to the heterogeneity of the methods for SCr measurements.…”

Section: Discussionmentioning

confidence: 96%

Creatinine-based GFR-estimating equations in children with overweight and obesity

2022

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Background With the increasing prevalence of childhood obesity and related development of chronic kidney disease (CKD), there is a critical need to understand how best to assess kidney function in children with obesity. Since serum creatinine (SCr) is recommended as marker of first choice for GFR estimation, we evaluated and compared creatinine-based GFR equations in children with overweight and obesity. Methods Six hundred children with overweight and obesity (53.5% female; mean age 12.20 ± 3.28 years; mean BMI z-score 3.31 ± 0.75) were included from the Centre for Overweight Adolescent and Children’s Healthcare (COACH). Results Serum creatinine (SCr), normalized using Q-age polynomials obtained from reference values, results in median and mean SCr/Q value close to “1” for all age groups, and 96.5% of the children have a SCr/Q within the reference band [0.67–1.33], corresponding to the 2.5th and 97.5th percentile. eGFR CKiD (bedside Schwartz equation) and Schwartz-Lyon decreased with age, whereas eGFR EKFC and modified CKD-EPI40 showed no age-dependency, but the distribution of eGFR values was not symmetrical. eGFR CKiD under 25 (CKiDU25) demonstrated no age-dependency but major sex differences were observed. eGFR FAS age, FAS height, and adjusted-creatinine revised Lund-Malmö (LMR18) showed a relatively symmetrical distribution and no age-dependency. Conclusions Serum creatinine (SCr) values of children with overweight and obesity are mostly within the reference range for children. Normalization of SCr using reference Q-age polynomials works very well in this cohort. After evaluation of the different equations, we suggest that FAS age, FAS height, and LMR18 are the preferred creatinine-based GFR-estimating equations in children with overweight and obesity. Clinical trial registration. ClinicalTrial.gov; Registration Number: NCT02091544. Graphical abstract A higher resolution version of the Graphical abstract is available as Supplementary information

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Section: Discussionmentioning

confidence: 96%

Creatinine-based GFR-estimating equations in children with overweight and obesity

2022

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“…Urinary excretion of H2O2 (U-H2O2) was evaluated by a microplate fluorimetric assay (Amplex Red Hydrogen Peroxide/Peroxidase Assay Kit; Molecular Probes, AlfaGene). Data concerning oxidative stress and NO bioavailability markers have been recently used by our group as part of studies on the same cohort to evaluate the association of these biomarkers with cardiometabolic risk, renal function and angiotensinogen 8,9,30 .…”

Section: Laboratory Proceduresmentioning

confidence: 99%

Gender-related differences in cardiometabolic risk factors and oxidative stress among prepubertal children with obesity

Godinho,

Morato,

Albino-Teixeira

et al. 2023

Journal of Pediatric Endocrinology and Metabolism

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Objectives Gender-related differences in oxidative stress, nitric oxide bioavailability, and cardiometabolic risk factors were examined in a cross-sectional study involving 313 prepubertal children (8–9 years old) from the generation XXI birth-cohort. Methods Anthropometric measurements, cardiometabolic variables, and redox markers were assessed, including plasma and urinary isoprostanes (P-Isop, U-Isop), plasma total antioxidant status (P-TAS), serum myeloperoxidase (MPO), plasma and urinary nitrates and nitrites (P-NOX, U-NOX), and urinary hydrogen peroxide (U-H2O2). Results Girls showed higher levels of total/non-HDL cholesterol, triglycerides, and insulin resistance (HOMA-IR) compared to boys. Notably, U-H2O2 values were lower in girls. When stratifying by body mass index (BMI) and gender, both girls and boys exhibited higher MPO concentration and U-Isop values. Uric acid concentration was higher in overweight and obese girls than in normal weight girls, while no significant differences were observed among boys across BMI categories. Furthermore, U-NOX values differed only in boys, with higher levels observed in overweight and obese individuals compared to those with normal weight. Multivariate analysis, adjusted for age and BMI z-score, demonstrated inverse associations between U-H2O2 and pulse wave velocity values, as well as between U-NOX and total or non-HDL cholesterol, exclusively in boys. In girls, a positive association between U-Isop and HOMA-IR values was observed. Conclusions In conclusion, gender differentially impacts oxidative stress, nitric oxide bioavailability, and cardiometabolic risk factors in prepubertal children. Prepubertal girls appear more susceptible to oxidative stress-induced metabolic dysfunction, while in boys, elevated levels of redox and nitric oxide bioavailability markers seem to provide protection against arterial stiffness and lipid homeostasis.

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“…Data concerning oxidative stress and markers of NO bioavailability have been recently used by our group as part of studies on the same cohort to evaluate the association of these biomarkers with cardiometabolic risk, renal function and angiotensinogen [3,21,33].…”

Section: Inflammatory and Oxidative Stress Biomarkersmentioning

confidence: 99%

Impact of physical activity on redox status and nitric oxide bioavailability in nonoverweight and overweight/obese prepubertal children

Leite-Almeida

Morato

Cosme

et al. 2021

Free Radical Biology and Medicine

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Longer duration of obesity is associated with a reduction in urinary angiotensinogen in prepubertal children

Cited by 3 publications

References 49 publications

Creatinine-based GFR-estimating equations in children with overweight and obesity

Creatinine-based GFR-estimating equations in children with overweight and obesity

Gender-related differences in cardiometabolic risk factors and oxidative stress among prepubertal children with obesity

Impact of physical activity on redox status and nitric oxide bioavailability in nonoverweight and overweight/obese prepubertal children

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