Long wavelength light that improves aged mitochondrial function selectively increases cytokine expression in serum and the retina

Abstract

Aged mitochondrial function can be improved with long wavelength light exposure. This reduces cellular markers of inflammation and can improve system function from fly though to human. Here, we ask what impact 670nm light has on cytokine expression using a 40 cytokine array in blood serum and retina in C57Bl6 mice. There was a relatively uniform increase in cytokine expression between 3 and 12 months of age in serum and retina.670nm exposure was delivered daily for a week in 12 month old mice. This shifted patterns of cytokine expression in both serum and retina inducing a selective increase with some in serum increasing >5 fold. Changes in retina were smaller. In serum there were major increases in IL-7, 6, 13, 16 and 23, also in TNF-α and CXCL 9 and 10. In retina the increases were found mainly in some IL (interleukins) and CXCL’s (chemokines). A few cytokines were reduced by light exposure.Changes in serum cytokines implies that long wavelengths impacts systemically even to unexposed tissues deep in the body. In the context of wider literature, increased cytokine expression may be protective. However, their upregulation by light merits further analysis as cytokines upregulation can also be negative.

Optical stimulation of mitochondria reduces blood glucose levels

“…[6] Signi cant reduction in blood glucose was observed following local red light illumination of the body, rather than requiring whole body exposure. Red light exposure has been shown to have an abscopal effect [22] and results in systemic changes in cytokine expression in the blood [23]. It is likely that this systemic cytokine change may play a role in the marked widespread changes in blood glucose to a distal region of illumination.…”