A new class of pattern forming systems is identified and investigated: anisotropic systems that are spatially inhomogeneous along the direction perpendicular to the preferred one. By studying the generic amplitude equation of this new class and a model equation, we show that branched stripe patterns emerge, which for a given parameter set are stable within a band of different wave numbers and different numbers of branching points (defects). Moreover, the branched patterns and unbranched ones (defect-free stripes) coexist over a finite parameter range. We propose two systems where this generic scenario can be found experimentally, surface wrinkling on elastic substrates and electroconvection in nematic liquid crystals, and relate them to the findings from the amplitude equation.