2012
DOI: 10.1371/journal.pone.0033415
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Long Time to Diagnosis of Medulloblastoma in Children Is Not Associated with Decreased Survival or with Worse Neurological Outcome

Abstract: BackgroundThe long time to diagnosis of medulloblastoma, one of the most frequent brain tumors in children, is the source of painful remorse and sometimes lawsuits. We analyzed its consequences for tumor stage, survival, and sequelae.Patients and MethodsThis retrospective population-based cohort study included all cases of pediatric medulloblastoma from a region of France between 1990 and 2005. We collected the demographic, clinical, and tumor data and analyzed the relations between the interval from symptom o… Show more

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Cited by 38 publications
(39 citation statements)
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“…It was not associated with an adverse outcome in medulloblastoma [20]. In leukemia patients, the delay did not have an impact on survival [21].…”
Section: Discussionmentioning
confidence: 81%
“…It was not associated with an adverse outcome in medulloblastoma [20]. In leukemia patients, the delay did not have an impact on survival [21].…”
Section: Discussionmentioning
confidence: 81%
“…As the most common malignant intracranial tumor in childhood, medulloblastoma represents a very heterogeneous group of biologically different tumor subsets arising from stem and/or progenitor cells of the cerebellum [1]. The clinical outcome for patients with medulloblastoma has been improved dramatically over the past decades.…”
Section: Introductionmentioning
confidence: 99%
“…Instead of questioning their study design, many have ignored statistically significant reverse effects and claimed that the time duration of both diagnostic and treatment processes is too short to have any clinical relevance(Brasme et al, 2012;Flemming et al, 2017;Iversen, Antonsen, Laurberg, & Lautrup, 2009;Nagle et al, 2011;Polissar, Sim, & Francis, 1981;Porta, Gallen, Malats, & Planas, 1991;Rupassara, Ponnusamy, Withanage, & Milewski, 2006;Sainsbury, Johnston, & Haward, 1999). Instead of questioning their study design, many have ignored statistically significant reverse effects and claimed that the time duration of both diagnostic and treatment processes is too short to have any clinical relevance(Brasme et al, 2012;Flemming et al, 2017;Iversen, Antonsen, Laurberg, & Lautrup, 2009;Nagle et al, 2011;Polissar, Sim, & Francis, 1981;Porta, Gallen, Malats, & Planas, 1991;Rupassara, Ponnusamy, Withanage, & Milewski, 2006;Sainsbury, Johnston, & Haward, 1999).…”
mentioning
confidence: 99%