“…The simple prescriptions to "eat less and move more" are becoming complicated by research findings that show how a 5 wide range of metabolic processes are affected by weight loss and implicated in the weight regain that often follows (e.g., Rosenbaum, Hirsch, Gallagher, & Leibel, 2008;Sumithran et al, 2011). Despite the increasing sophistication of exercise and nutrition programs designed for weight loss, sustained weight loss remains an elusive goals for many people; although the precise success rate for long term maintenance of weight loss is difficult to determine, a recent review suggests that only around 17% of Americans who have ever been overweight or obese have maintained a loss of at least 10% of their body weight for at least one year (Kraschnewski et al, 2010). In addition to the considerable problems with establishing the efficacy of weight loss programs, there is the potential for iatrogenic effects of deliberate weight loss attempts.…”