Long-Term Weight Gain Associated With High Omentin Levels at Hospital Discharge Improves Prognosis of Patients Following Acute Heart Failure

Agra-Bermejo, Rosa; González‐Ferreiro, Rocío; Lopez-Canoa, J N; Varela-Román, Alfonso; Gómez-Otero, Inés; Eiras, Sonia; González-Juanatey, José Ramón

doi:10.1007/s12265-018-9840-y

Cited by 5 publications

(5 citation statements)

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“…There were few studies that investigated the prognostic impact of weight loss after discharge in patients with AHF. Agra-Bermejo et al reported that 21.7% of the 92 patients with AHF had �6% weight loss at 6-month after discharge with a mean BMI of 30 in Spain, who were associated with poor outcomes [12]. In our study, 13.1% of the patients had �5% weight loss at 6-month…”

Section: Proportion Of Patients With Weight Loss In Patients With Ahf...supporting

confidence: 46%

Weight loss during follow-up in patients with acute heart failure: From the KCHF registry

et al. 2023

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Backgrounds The prognostic implication of weight loss after discharge from acute heart failure (AHF) remains unclear. We sought to investigate the association of weight loss between discharge and 6-month visit with subsequent clinical outcomes in patients with AHF. Methods We analyzed 686 patients with AHF in the prospective longitudinal follow-up study derived from the Kyoto Congestive Heart Failure registry, and divided them into 2 groups based on the weight loss at 6-month index visit. We defined the weight loss as ≥ 5% decrease in body weight from discharge to 6-month index visit. Results There were 90 patients (13.1%) with a weight loss at 6-month visit. Patients in the weight loss group compared with those in the no weight loss group had higher body weight at discharge and lower body weight at 6-mont visit. Patients in the weight loss group had a lower systolic blood pressure, higher brain-type natriuretic peptide, lower serum albumin, lower hemoglobin, higher prevalence of heart failure with reduced ejection fraction at 6-month visit, and a lower prescription rate of inhibitors of renin-angiotensin system than those in the no weight loss group. The cumulative 6-month incidence of all-cause death was significantly higher in the weight loss group than in the no weight loss group (14.2% and 4.3%, log-rank P<0.001). The excess adjusted risk of the weight loss group relative to the no weight loss group remained significant for all-cause death (HR 2.39, 95%CI 1.01–5.65, P = 0.048). Conclusion Body weight loss of ≥5% at 6-month visit after discharge was associated with subsequent all-cause death in patients with AHF.

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Section: Proportion Of Patients With Weight Loss In Patients With Ahf...supporting

confidence: 46%

Weight loss during follow-up in patients with acute heart failure: From the KCHF registry

et al. 2023

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“…It was reported that increasing omentin‐1 concentrations may lower the risk of mortality among ischemic stroke patients 16 . High omentin levels at hospital discharge could improve the prognosis of patients following acute heart failure 17 . Furthermore, several studies have demonstrated that decreased levels of omentin‐1 may be involved in the occurrence and development of coronary artery disease and predict the prevalence of CHD 18,19 .…”

Section: Discussionmentioning

confidence: 99%

“… 16 High omentin levels at hospital discharge could improve the prognosis of patients following acute heart failure. 17 Furthermore, several studies have demonstrated that decreased levels of omentin‐1 may be involved in the occurrence and development of coronary artery disease and predict the prevalence of CHD. 18 , 19 In addition, the previous studies revealed that omentin levels were significantly decreased in HF and were closely associated with HF severity.…”

Section: Discussionmentioning

confidence: 99%

Association between omentin‐1 and heart failure with preserved ejection fraction in Chinese elderly patients

Su,

Tian,

Liang

et al. 2023

Clinical Cardiology

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BackgroundOmentin‐1 is a novel adipokine and is associated with chronic inflammation and cardiovascular diseases. However, it remains unclear whether omentin‐1 levels are associated with diagnostic significance in elderly patients with heart failure with preserved ejection fraction (HFpEF). This study aimed to investigate the correlation between omentin‐1 and HFpEF in Chinese elderly patients.HypothesisOmentin‐1 may be invovled in HFpEF and there may be a difference of omentin‐1 levels between HFpEF and control.Methods217 subjects were selected, including 115 patients with HFpEF and 102 control subjects. Enzyme‐linked immuno sorbent assay (ELISA) was used to detect plasma levels of omentin‐1, tumor necrosis factor‐α (TNF‐α) and interleukin‐6 (IL‐6). The receiver operating characteristics (ROC) curve was used to examine the diagnostic performance of omentin‐1 in HFpEF.ResultsThe levels of omentin‐1 decreased significantly in the HFpEF group (14.02 ± 8.35 vs. 19.74 ± 8.45 ng/mL, p < .001), while NT‐proBNP, IL‐6, and TNF‐α levels were significantly increased in the HFpEF group compared with the control group. Spearman correlation analysis showed that omentin‐1 levels were negatively correlated with E/e' (r = −.340, p < .001). The multivariate logistic regression analysis indicated that omentin‐1 was an independent protective factor for HFpEF (odd ratio = 0.948, 95% confidence interval [CI] 0.905–0.993, p = .025). Omentin‐1 levels were negatively correlated with NT‐proBNP (r = −.273, p < .001) and TNF‐α (r = −.221, p = .001). Diagnostic efficiency by ROC curve analysis in the patients with HFpEF showed that the area under the curve (AUC) for omentin‐1 was equivalent to NT‐proBNP (AUC: 0.734, 95%CI 0.667–0.802; AUC: 0.800, 95%CI 0.738–0.861). Subgroup analysis showed that in the patients between the age of 70 and 80, the predictive capability of omentin‐1 was stronger than NT‐proBNP (AUC: 0.809, 95%CI 0.680–0.937; AUC: 0.674, 95%CI 0.514–0.833).ConclusionsOmentin‐1 levels which were associated with inflammation, were decreased in the HFpEF patients. It could be regarded as a valuable biomarker for the occurrence and development of HFpEF in elderly patients.

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“…Therefore, the elevated circulating levels of omentin-1 were mildly and positively associated with cardiac volumes and systolic function and negatively correlated with adiponectin, high-sensitivity C-reactive protein, and N-terminal pro-BNP (NT-proBNP) in HF patients ( 148 , 149 ). In addition, the elevated levels of omentin-1 were an independent predictor of weight gain in patients with acutely decompensated and chronic HF who had less mortality rate and hospital readmission regardless of leptin and NT-proBNP levels ( 150 , 151 ). However, the primary cause of a positive impact of omentin-1 on mortality among HF patients remains uncertain.…”

Section: Adipose Tissue Dysfunction and Heart Failurementioning

confidence: 93%

Emerging Role of Adipocyte Dysfunction in Inducing Heart Failure Among Obese Patients With Prediabetes and Known Diabetes Mellitus

Berezin

Lichtenauer

2020

Front. Cardiovasc. Med.

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Adipose tissue dysfunction is a predictor for cardiovascular (CV) events and heart failure (HF) in patient population with obesity, metabolic syndrome, and known type 2 diabetes mellitus. Previous preclinical and clinical studies have yielded controversial findings regarding the role of accumulation of adipose tissue various types in CV risk and HF-related clinical outcomes in obese patients. There is evidence for direct impact of infiltration of epicardial adipocytes into the underlying myocardium to induce adverse cardiac remodeling and mediate HF development and atrial fibrillation. Additionally, perivascular adipocytes accumulation is responsible for release of proinflammatory adipocytokines (adiponectin, leptin, resistin), stimulation of oxidative stress, macrophage phenotype switching, and worsening vascular reparation, which all lead to microvascular inflammation, endothelial dysfunction, atherosclerosis acceleration, and finally to increase in CV mortality. However, systemic effects of white and brown adipose tissue can be different, and adipogenesis including browning of adipose tissue and deficiency of anti-inflammatory adipocytokines (visfatin, omentin, zinc-α2-glycoprotein, glypican-4) was frequently associated with adipose triglyceride lipase augmentation, altered glucose homeostasis, resistance to insulin of skeletal muscles, increased cardiomyocyte apoptosis, lowered survival, and weak function of progenitor endothelial cells, which could significantly influence on HF development, as well as end-organ fibrosis and multiple comorbidities. The exact underlying mechanisms for these effects are not fully understood, while they are essential to help develop improved treatment strategies. The aim of the review is to summarize the evidence showing that adipocyte dysfunction may induce the onset of HF and support advance of HF through different biological mechanisms involving inflammation, pericardial, and perivascular adipose tissue accumulation, adverse and electrical cardiac remodeling, and skeletal muscle dysfunction. The unbalancing effects of natriuretic peptides, neprilysin, and components of renin-angiotensin system, as exacerbating cause of altered adipocytokine signaling Berezin et al. Adipocyte Dysfunction in Heart Failure on myocardium and vasculature, in obesity patients at high risk of HF are disputed. The profile of proinflammatory and anti-inflammatory adipocytokines as promising biomarker for HF risk stratification is discussed in the review.

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Long-Term Weight Gain Associated With High Omentin Levels at Hospital Discharge Improves Prognosis of Patients Following Acute Heart Failure

Cited by 5 publications

References 50 publications

Weight loss during follow-up in patients with acute heart failure: From the KCHF registry

Weight loss during follow-up in patients with acute heart failure: From the KCHF registry

Association between omentin‐1 and heart failure with preserved ejection fraction in Chinese elderly patients

Emerging Role of Adipocyte Dysfunction in Inducing Heart Failure Among Obese Patients With Prediabetes and Known Diabetes Mellitus

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