Long-term use of clomiphene citrate in induction of ovulation in PCO patients with clomiphene citrate resistance

Low dose Aspirin with clomid in pco

“…The polycystic ovary syndrome (PCOS) is the commonest cause of an ovulatory infertility accounting for approximately 75% of the cases. (Elkhateeb et al, 2017). PCOS is the most common form of WHO type II anovulatory infertility, and is the most common endocrine abnormality in reproductive age women.…”

“…Pituitary and this is often enough to reset the cycle of events leading to ovulation. This is achieved indirectly, through the action of CC, a non-steroidal compound closely resembling an estrogen, in blocking hypothalamic estrogen receptors, signaling a lack of circulating estrogen to the hypothalamus and inducing change in the pattern of pulsatile release of GnRH (Elkhateeb et al, 2017).…”

“…Clomiphene resistance defined as failure to ovulate after receiving 150 mg of CC daily for 5 days per cycle, for at least three cycles, is common and occurs in approximately 15 to 40% in Failure of CC to induce ovulation or CC resistance, is unpredictable and women with PCOS (National Collaborating Centre for Women's and Children's Health, National Institute, 2005). Foremost unexplainable event, some studies showed thatit is more likely in patients who are obese, insulin resistant and hyperandrogenic a genetic predisposition was suggested (Elkhateeb et al, 2017).…”

“…However, managed care studies have shown that the most effective dosage 100-150 mg/day and over 75% of ovulations occur within these dosages. After six to nine cycles of treatment with CC cumulative pregnancy rates reach 70-75% (Elkhateeb et al, 2017). Low dose Aspirin with clomid in pco Low-dose aspirin (LDA) has been shown to increase both ovarian and uterine blood flow through inhibiting the synthesis of thromboxane A2 resulting in vasodilatation and inhibition It was suggested that LDA treatment significantly improves of platelets aggregation (Aref et al, 2019).…”