Long-term use of bisphosphonates in osteoporosis

Sadat-Ali, Mir; AlAnii, Fawaz M

doi:10.15537/smj.2017.8.20748

Cited by 4 publications

(2 citation statements)

References 6 publications

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“…However, these treatment options primarily target the suppression of osteoclast activity, and their efficacy in treating osteoporosis associated with conditions other than postmenopausal hormone deficiency is limited [6]. Moreover, these medications are often associated with significant side effects, including gastrointestinal disturbances, musculoskeletal pain, and rare but serious complications such as atypical femoral fractures and osteonecrosis of the jaw [7]. Consequently, this restricted approach fails to address the diverse and evolving needs of the osteoporosis patient population.…”

Section: Introductionmentioning

confidence: 99%

Dolichos Lablab Linné Inhibits Bone Density Loss and Promotes Bone Union in Senile Osteoporosis through Osteogenesis

Kim,

Hong

et al. 2023

Pharmaceuticals

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As populations continue to age, osteoporosis has emerged as an increasingly critical concern. Most advancements in osteoporosis treatment are predominantly directed toward addressing abnormal osteoclast activity associated with menopause, with limited progress in developing therapies that enhance osteoblast activity, particularly in the context of aging and fractures, and serious side effects associated with existing treatments have highlighted the necessity for natural-product-based treatments targeting senile osteoporosis and fractures. Dolichos lablab Linné (DL) is a natural product traditionally used for gastrointestinal disorders, and its potential role in addressing bone diseases has not been extensively studied. In this research, we investigated the anti-osteoporosis and bone-union-stimulating effects of DL using the SAMP6 model, a naturally aged mouse model. Additionally, we employed MC3T3-E1 cells to validate DL’s osteoblast-promoting effect and to assess the involvement of core mechanisms such as the BMP-2/Smad and Wnt/β-catenin pathways. The experimental results revealed that DL promoted the formation of osteoblasts and calcified nodules by upregulating both the BMP-2/Smad and Wnt/β-catenin mechanisms. Based on its observed effects, DL demonstrated the potential to enhance bone mineral density in aged osteoporotic mice and promote bone union in fractured mice. These findings indicate the promising therapeutic potential of DL for the treatment of osteoporosis and bone-related conditions, thus warranting further investigation and potential clinical applications.

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Section: Introductionmentioning

confidence: 99%

Dolichos Lablab Linné Inhibits Bone Density Loss and Promotes Bone Union in Senile Osteoporosis through Osteogenesis

Kim,

Hong

et al. 2023

Pharmaceuticals

View full text Add to dashboard Cite

show abstract

“…It usually occurs in middle-aged and elderly people, and can be clinically manifested as pain, shortening of body length, hunchback and decreased respiratory function. Osteoporotic fractures are prone to occur due to increased bone fragility and decreased bone strength, with limited post-fracture mobility and complications, which bring a heavy burden to patients and their families (1). At present, there are many clinical theories about the etiology of osteoporosis, among which the relationship between abnormal iron metabolism and osteoporosis has become the focus of attention at home and abroad (2).…”

Section: Introductionmentioning

confidence: 99%