Long-term use of a diabetes-specific oral nutritional supplement results in a low-postprandial glucose response in diabetes patients

Magnoni, Daniel; Rouws, C.; Lansink, Mirian; Laere, K.M.J. van; Campos, Antônio Carlos Ligocki

doi:10.1016/j.diabres.2007.10.027

Cited by 25 publications

(16 citation statements)

References 22 publications

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“…Durations of follow-up ranged from 4 to 12 weeks, and sample sizes were small (12–60 participants in the fiber intervention). All studies were randomized; all studies analyzed participants according to treatment assignment; completion of follow-up was >80% for two of the studies (46,51); two of the studies blinded participants to diet treatment (48,51); and two were double-blinded (45,46). In general, these studies support the idea that fiber supplements may improve postprandial glycemia; however, little improvement in A1C was observed.…”

Section: Carbohydrate Typementioning

confidence: 99%

Macronutrients, Food Groups, and Eating Patterns in the Management of Diabetes

Wheeler¹,

et al. 2012

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Section: Carbohydrate Typementioning

confidence: 99%

Macronutrients, Food Groups, and Eating Patterns in the Management of Diabetes

Wheeler¹,

et al. 2012

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“…In addition to previous studies examining fiber-rich whole foods, fiber supplement trials provide further support that dietary fiber may improve PPG in T2DM (138,140). In a group of 40 T2DM patients at risk of malnutrition, Magnoni et al (140) demonstrated that postprandial glucose excursion and iAUC were significantly lower in the group supplemented with a high-MUFA, NU35CH05- Tay ARI 28 April 2015 14:15 high-fiber (10 g fiber) oral nutrition supplement consumed over 12 weeks, compared to a control group supplemented with an isocaloric, fiber-free standard oral nutrition supplement.…”

Section: Dietary Fibermentioning

confidence: 89%

Glycemic Variability: Assessing Glycemia Differently and the Implications for Dietary Management of Diabetes

2015

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The primary therapeutic target for diabetes management is the achievement of good glycemic control, of which glycated hemoglobin (HbA1c) remains the standard clinical marker. However, glycemic variability (GV; the amplitude, frequency, and duration of glycemic fluctuations around mean blood glucose) is an emerging target for blood glucose control. A growing body of evidence supports GV as an independent risk factor for diabetes complications. Several techniques have been developed to assess and quantify intraday and interday GV. Additionally, GV can be influenced by several nutritional factors, including carbohydrate quality, quantity; and distribution; protein intake; and fiber intake. These factors have important implications for clinical nutrition practice and for optimizing blood glucose control for diabetes management. This review discusses the available evidence for GV as a marker of glycemic control and risk factor for diabetes complications. GV quantification techniques and the influence of nutritional considerations for diabetes management are also discussed.

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“…Figueiredo et al (2006) avaliaram o efeito de suplementação com a fi bra solúvel goma guar por 3 meses em pacientes com DM2 e observaram que o IMC deles não foi alterado ao longo do estudo (p = 0,77). Magnoni et al (2008), em seu estudo de 12 semanas com pacientes diabéticos, não verifi caram alterações signifi cativas tanto no peso corporal quanto no IMC.…”

Section: Discussionunclassified

“…Todavia, aumentos signifi cativos foram observados (p < 0,001) nos níveis de HbA1c durante o estudo. Magnoni et al (2008), também não verifi caram alterações signifi cativas nos níveis de glicose basal e HbA1c (p = 0,056 e 0,569, respectivamente) em seu estudo de 12 semanas com pacientes diabéticos.…”

Section: Discussionunclassified

Efeito da farinha da casca do maracujá-amarelo (Passiflora edulis f. flavicarpa Deg.) nos níveis glicêmicos e lipídicos de pacientes diabéticos tipo 2

Janebro¹,

Queiroz²,

Ramos³

et al. 2008

Rev. bras. farmacogn.

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RESUMO: A suplementação da dieta com fi bras solúveis pode ser considerada uma importante medida terapêutica no tratamento de pacientes diabéticos e obesos. Para avaliar o efeito da farinha da casca de maracujá amarelo rica em pectina, foi realizado um ensaio clínico fase II com 43 pacientes portadores de Diabetes Mellitus tipo 2. Estes receberam diariamente 30 g do produto testado durante 60 dias. Observou-se diferença estatística signifi cante na glicemia de jejum (p = 0,000) acompanhada pela redução nos valores médios da hemoglobina glicada (p = 0,032). Em relação ao perfi l lipídico, não foi verifi cado redução dos níveis de colesterol total e colesterol LDL nos pacientes ao longo deste estudo; entretanto, houve redução nos níveis de Triglicerídeos e aumento do colesterol HDL nos mesmos. Os níveis glicêmicos apresentados pelos pacientes antes e após o uso da farinha da casca do maracujá são compatíveis com uma ação positiva no controle da glicemia como adjuvante das terapias convencionais. Unitermos:Passifl ora edulis, Passifl oracea, pectina, diabetes, atividade hipoglicemiante, produtos naturais.ABSTRACT: "Effect of the fl our of the yellow passion fruit peel (Passifl ora edulis f. fl avicarpa Deg.) in the glycemic and lipid levels of type 2 diabetes patients". The supplementation of diet with soluble dietary fi ber can be considered an important therapy measure in the treatment of diabetic and obese patients. In order to evaluate the effect of the fl our of the yellow passion fruit peel which is rich in pectin, a phase II clinical trial with 43 patients with type 2 Diabetes Mellitus was performed. They received daily 30 g of the tested product for 60 days. Statistically signifi cant difference was observed in fasting plasma glucose (p = 0.000) accompanied by a reduction in the average values of glycated hemoglobin (p = 0.032). In relation to the lipid profi le, there were no reduced levels of total cholesterol and LDL-cholesterol in patients during this study; however, there were reduction in the levels of Triglycerides and increase in HDL cholesterol in them. The glycemic levels presented by the patients before and after the use of the passion fruit peel fl our are compatible to a positive action to control blood glucose as an adjunct of conventional therapies. Keywords:Passifl ora edulis, Passifl oracea, pectin, diabetes, hypoglycemic activity, natural products. INTRODUÇÃOO Diabetes Mellitus (DM) constitui um grave problema de saúde pública por sua alta prevalência na população, suas complicações crônicas, mortalidade, altos custos fi nanceiros e sociais envolvidos no tratamento e deterioração signifi cativa da qualidade de vida.Em países, como o Brasil, está previsto aumento na prevalência de DM de 170% no período de 1995de a 2025de (King et al., 1998Narayan et al., 2000;Figueiredo & Modesto-Filho, 2008). Mesmo em países desenvolvidos, apesar dos avanços científi cos e o acesso fácil a cuidados contínuos de saúde, a prevalência do diabetes está aumentando e intervenções com a fi nalidade de prev...

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Long-term use of a diabetes-specific oral nutritional supplement results in a low-postprandial glucose response in diabetes patients

Cited by 25 publications

References 22 publications

Macronutrients, Food Groups, and Eating Patterns in the Management of Diabetes

Macronutrients, Food Groups, and Eating Patterns in the Management of Diabetes

Glycemic Variability: Assessing Glycemia Differently and the Implications for Dietary Management of Diabetes

Efeito da farinha da casca do maracujá-amarelo (Passiflora edulis f. flavicarpa Deg.) nos níveis glicêmicos e lipídicos de pacientes diabéticos tipo 2

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