Long‐term use and tapered dose reduction of intranasal desmopressin in the treatment of enuretic children

Abstract

Objective To determine the time taken to achieve comwith no relapses, remaining dry with no further treatment, 7% achieved dryness after relapses during plete dryness, the management of desmopressin dosage to reduce the relapse rate, the mean dosage in those or after therapy, 7% improved (no more than two wet nights per week) and 15% did not respond to therapy responding and any side eCects of long-term treatment. Patients and methods Enuretic children (155, 68% boys or improved only slightly (>2 wet nights per week). The mean duration of therapy was 28 weeks, the and 32% girls, mean age 8 years, range 5-19) were treated with desmopressin and assessed. Treatment mean dose of desmopressin was 30 mg and the median follow-up 18 months. There were no significant side-(intranasal spray) was started with 20 mg desmopressin and titrated to 40 mg (maximum 50 mg) after eCects. Conclusion This study indicates that rapid titration until 2 days if the child did not become dry within 48 h. The maximum dosage was maintained for at least dryness within 1-3 days, a long maintenance therapy of at least 4-6 weeks and a slow stepwise reduction 4-6 weeks. After 4 weeks of complete dryness, the dosage was reduced by 10 mg initially, and after each of dose decreases the frequency of relapse and improves the outcome. additional 4 dry weeks, by a further 10 mg; medication was stopped only after 4 dry weeks at 10 mg.

Management of nocturnal enuresis in Greek children

“…In Moffatt's review of randomized clinical studies using desmopressin therapy, nearly all studies demonstrated a statistically significant reduction in wet nights [6]. Moreover, studies have demonstrated that desmopressin was effective at rapidly reducing bedwetting in a variety of doses and forms [7,8,9]. In our study, intranasal desmopressin provided an effective and well-tolerated means of providing control in children with nocturnal enuresis.…”

Comparing alarms, desmopressin, and combined treatment in Chinese enuretic children

“…Discontinuation of desmopressin at 3 months might have led to prompt relapse. Since the start of our study, reports of long-term treatment with desmopressin for up to 1 or 2 years have shown long-lasting remission rates [21,28]. Secondly, some of our patients may have subclinical dysfunctional voiding, although this did not manifest as daytime urinary symptoms, as noted by Yeung et al [27].…”

Evaluation und management of enuresis

“…Vorzeitige Auslassversuche sind meist sinnlos und re sultieren in einer hohen Rückfallquote. Bei korrekter Dosierung und Anwendung liegt die Erfolgs rate bei 70% [18,19].…”