Long-Term Urban Particulate Air Pollution, Traffic Noise, and Arterial Blood Pressure

Fuks, Kateryna; Moebus, Susanne; Hertel, Sabine; Viehmann, Anja; Nonnemacher, Michael; Dragano, Nico; Möhlenkamp, Stefan; Jakobs, Hermann; Keßler, Christoph; Erbel, Raimund; Hoffmann, Barbara

doi:10.1289/ehp.1103564

Cited by 166 publications

(186 citation statements)

References 35 publications

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“…31 These three hypotheses provide contextual background to evaluate the experimental and clinical findings describing the extrapulmonary effect of particulate matter air pollution, where it has been reported that exposure to elevated levels of PM 2.5 is associated with increased inflammatory mediators (including TNF-a, IL-6, and plasminogen activator inhibitor-1), oxidative stress, [32][33][34] increased atherosclerotic plaque area, and exaggerated vasoconstrictor responses to phenylephrine and serotonin. 35 Evidence suggests that increased PM 2.5 concentrations are associated with significant decrease in flow-mediated dilatation, 36,37 increases in systolic BP and pulse pressure, [38][39][40] and disturbances in the hypothalamic-pituitary-adrenal axis. 41 Emerging evidence also suggests that exposure to ambient air pollutants can lead to metabolic disturbances, including glucose intolerance, decreased insulin sensitivity, higher blood lipid concentrations, weight gain, and increased risk of diabetes mellitus.…”

Section: Discussionmentioning

confidence: 99%

Particulate Matter Air Pollution and the Risk of Incident CKD and Progression to ESRD

Bowe¹,

Xie²,

Li³

et al. 2017

JASN

242

236

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Elevated levels of fine particulate matter ,2.5 mm in aerodynamic diameter (PM 2.5 ) are associated with increased risk of cardiovascular outcomes and death, but their association with risk of CKD and ESRD is unknown. We linked the Environmental Protection Agency and the Department of Veterans Affairs databases to build an observational cohort of 2,482,737 United States veterans, and used survival models to evaluate the association of PM 2.5 concentrations and risk of incident eGFR ,60 ml/min per 1.73 m 2 , incident CKD, eGFR decline $30%, and ESRD over a median follow-up of 8.52 years. In time-varying analyses, a 10-mg/m 3 increase in PM 2.5 concentration was associated with similarly increased risk of eGFR,60 ml/min per 1.73 m 2 , CKD, eGFR decline $30%, and ESRD. Spline analyses showed a linear relationship between PM 2.5 concentrations and risk of kidney outcomes. Exposure estimates derived from National Aeronautics and Space Administration satellite data yielded consistent results. Our findings demonstrate a significant association between exposure to PM 2.5 and risk of incident CKD, eGFR decline, and ESRD.

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Section: Discussionmentioning

confidence: 99%

Particulate Matter Air Pollution and the Risk of Incident CKD and Progression to ESRD

Bowe¹,

Xie²,

Li³

et al. 2017

JASN

242

236

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“…Those who have done so found that excess risks of air pollution in the proximity of roads generally remained after adjustment for noise for cardiovascular mortality (Beelen et al, 2008a;Gan et al, 2012), hypertension and diabetes mellitus (Coogan et al, 2012), hypertension (Fuks et al, 2011;Sørensen et al, 2012), and cognitive performance of primary schoolchildren (van Kempen et al, 2012). Therefore, these studies show effects of air pollution that cannot be explained by noise.…”

Section: Rationalementioning

confidence: 95%

A rapid assessment of the impact of hazard reduction burning around Sydney, May 2016

Broome¹,

Johnston

Horsley

et al. 2016

Medical Journal of Australia

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This document presents answers to 24 questions relevant to reviewing European policies on air pollution and to addressing health aspects of these policies. The answers were developed by a large group of scientists engaged in the WHO project "Review of evidence on health aspects of air pollution -REVIHAAP". The experts reviewed and discussed the newly accumulated scientific evidence on the adverse effects on health of air pollution, formulating science-based answers to the 24 questions. Extensive rationales for the answers, including the list of key references, are provided. The review concludes that a considerable amount of new scientific information on the adverse effects on health of particulate matter, ozone and nitrogen dioxide, observed at levels commonly present in Europe, has been published in recent years. This new evidence supports the scientific conclusions of the WHO air quality guidelines, last updated in 2005, and indicates that the effects in some cases occur at air pollution concentrations lower than those serving to establish these guidelines. It also provides scientific arguments for taking decisive actions to improve air quality and reduce the burden of disease associated with air pollution in Europe.This publication arises from the project REVIHAAP and has been co-funded by the European Union. Keywords AIR POLLUTANTS AIR POLLUTION -ADVERSE EFFECTS ENVIRONMENT AND PUBLIC HEALTH EVIDENCE BASED PRACTICE GUIDELINES HEALTH POLICYAddress requests about publications of the WHO Regional Office for Europe to: Publications WHO Regional Office for Europe Scherfigsvej 8 DK-2100 Copenhagen Ø, Denmark Alternatively, complete an online request form for documentation, health information, or for permission to quote or translate, on the Regional Office web site (http://www.euro.who.int/pubrequest). © World Health Organization 2013All rights reserved. The Regional Office for Europe of the World Health Organization welcomes requests for permission to reproduce or translate its publications, in part or in full.The designations employed and the presentation of the material in this publication do not imply the expression of any opinion whatsoever on the part of the World Health Organization concerning the legal status of any country, territory, city or area or of its authorities, or concerning the delimitation of its frontiers or boundaries. Dotted lines on maps represent approximate borderlines for which there may not yet be full agreement.The mention of specific companies or of certain manufacturers products does not imply that they are endorsed or recommended by the World Health Organization in preference to others of a similar nature that are not mentioned. Errors and omissions excepted, the names of proprietary products are distinguished by initial capital letters.All reasonable precautions have been taken by the World Health Organization to verify the information contained in this publication. However, the published material is being distributed without warranty of any kind, either express or implied. ...

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“…41 Oxidative stress may also increase the circulation of activated inflammatory cytokines, which may subsequently induce endothelial dysfunction, lead to an imbalance in vascular homeostatic response, and result in total peripheral resistance and a fixation of evaluated blood pressure. 40,42 PM may also elevate blood pressure by inducing autonomic nervous system imbalance and vasoconstriction. 24 In addition, PM exposure can also reduce daytime sodium excretion and blunt the normal nocturnal reduction in blood pressure.…”

mentioning

confidence: 99%

Associations of Short-Term and Long-Term Exposure to Ambient Air Pollutants With Hypertension

et al. 2016

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C ardiovascular disease is the leading cause of death in the world. It is responsible for ≈30% of all deaths or ≈17.5 million people in 2012.1 As the major risk factor for cardiovascular disease, hypertension has been identified as the most important cause of disability and the leading risk factor for death globally and causes ≈16.5% of all deaths.2 The causes of hypertension are complex and are related to genetic factors, lifestyle, diet structure, and environmental factors, including air pollution.3 Since the 1990s, many epidemiological studies have investigated the associations between air pollution exposure and hypertension. However, the results remain controversial. Some studies have shown an association, 4-8 whereas other studies have found either no association or an association only for selected pollutants or limitation based on short-term or long-term exposure.9-12 These inconsistent and controversial results indicate the need to quantitatively synthesize and interpret the available evidence to provide more explicit information for policy decisions and clinical use. Meta-analysis is the most commonly used statistical technique to quantitatively synthesize results from ≥2 separate studies. 13 To our knowledge, there is only one meta-analysis that summarized the association between exposure to traffic-related air pollution and hypertension.14 However, this study included only cohort studies conducted in the Europe and mainly focused on the traffic-related air pollutants, which might limit the external validity of their findings. Therefore, more such meta-analyses are urgently needed.The previous published studies on hypertension and air pollution can be broadly divided into 2 categories: short-term and long-term studies. The former estimate the acute effects of air pollution exposure and mostly include time-series analyses over a few days. The latter evaluate the chronic effects of air pollution, such as cohort survival analyses over years of exposure. 15The short-term and long-term effects of air pollution may have Abstract-Hypertension is a major disease of burden worldwide. Previous studies have indicated that air pollution might be a risk factor for hypertension, but the results were controversial. To fill this gap, we performed a meta-analysis of epidemiological studies to investigate the associations of short-term and long-term exposure to ambient air pollutants with hypertension. We searched all of the studies published before September 1, 2015, on the associations of ozone (O 3 ), carbon monoxide (CO), nitrogen oxide (NO 2 and NO X ), sulfur dioxide (SO 2 ), and particulate matter (PM 10 and PM 2.5 ) with hypertension in the English electronic databases. A pooled odds ratio (OR) for hypertension in association with each 10 μg/m 3 increase in air pollutant was calculated by a random-effects model (for studies with significant heterogeneity) or a fixed-effect model (for studies without significant heterogeneity). A total of 17 studies examining the effects of short-term (n=6) and long-term exposure ...

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Long-Term Urban Particulate Air Pollution, Traffic Noise, and Arterial Blood Pressure

Cited by 166 publications

References 35 publications

Particulate Matter Air Pollution and the Risk of Incident CKD and Progression to ESRD

Particulate Matter Air Pollution and the Risk of Incident CKD and Progression to ESRD

A rapid assessment of the impact of hazard reduction burning around Sydney, May 2016

Associations of Short-Term and Long-Term Exposure to Ambient Air Pollutants With Hypertension

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