Long-term triple tetracycline ("Deteclo") treatment of non-specific urethritis.

Bhattacharyya, M. N.; Morton, R S

doi:10.1136/sti.49.6.521

Cited by 10 publications

(10 citation statements)

References 6 publications

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“…Prolonged courses lasting up to three weeks have been advocated, but the results reported B. A. Evans fall within the figures quoted above (John, 1971;Bhattacharyya and Morton, 1973). The current trial is the first to report the effect of low-dose oxytetracycline (250mg twice daily).…”

Section: Discussionsupporting

confidence: 72%

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The role of tetracyclines in the treatment of non-specific urethritis.

Evans¹

1977

Sexually Transmitted Infections

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suMMARY An assessment of the clinical findings and treatment in 400 patients with non-specific urethritis (NSU) is reported, and the effect of treating their contacts is analysed. Three tetracyclines were compared in a randomised trial which showed that low-dose oxytetracycline (250 mg twice a day) was as effective as preparations formulated specifically for twice daily administration (triple tetracycline and sustained-release tetracycline hydrochloride). The question of multiple aetiology was explored by testing statistically whether various clinical features such as age, incubation period, severity of symptoms, and previous infection were related to outcome. No subgrouping of the condition could be found. Clinical relapse proved to be independent of empirical treatment of asymptomatic contacts, which therefore appeared not to confer any benefit on either partner. It is suggested that the infective aspect of NSU is readily controlled, and that other factors, probably psychological, determine relapse.

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Section: Discussionsupporting

confidence: 72%

“…Treatment of NSU with a single course of a tetracycline was unsuccessful in 10 to 20% of patients observed during a period of three months (Willcox et al, 1975 (John, 1971;Bhattacharyya and Morton, 1973). The current trial is the first to report the effect of low-dose oxytetracycline (250mg twice daily).…”

Section: Discussionmentioning

confidence: 81%

The role of tetracyclines in the treatment of non-specific urethritis.

Evans¹

1977

Sexually Transmitted Infections

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“…(Fowler, 1970). The findings in the Deteclo series are by no means as impressive as those obtained by Bhattacharyya and Morton (1973) with a smaller amount of Deteclo (300 mg. 12-hrly for 3 weeks). Nor are they as good as those reported by John (1971) after oxytetracycline 250 mg. 6-hrly for the same length of time, although experience in this Clinic indicates that Deteclo is not inferior to the other tetracyclines in the treatment of NSU (Fowler and Bernstein, 1969).…”

Section: Discussioncontrasting

confidence: 53%

“…for 4 days "Percentage of cases followed D This is a remarkably low figure for this Clinic. A low default rate was a marked feature also of the trial carried out by Bhattacharyya and Morton (1973) and, although no attention is drawn to it, would appear to have been a feature of the trial reported by John (1971). It was formerly thought that the low default rate could have been partly due to selection of cases, but it was more probably due to the detailed explanation given by the nursing staff.…”

Section: Resultsmentioning

confidence: 97%

Intensive and prolonged tetracycline therapy in non-specific urethritis.

Helmy¹,

Fowler²

1975

Sexually Transmitted Infections

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“…It is in doubt whether or not partners of men with NGU should be treated (Bhattacharyya and Morton, 1973;Evans, 1977). Although the numbers were small, our findings (Table 4) showed that among those whose partners were not treated patients given the seven-day regimen had a significantly higher recurrence rate than patients given the 21-day regimen.…”

Section: Discussionmentioning

confidence: 60%