Long-term trends in incidence, survival and mortality of primary penile cancer in England

Arya, Manit; Li, Ruoran; Pegler, Kat; Sangar, Vijay; Kelly, John D.; Minhas, Suks; Muneer, Asıf; Coleman, Michel P

doi:10.1007/s10552-013-0293-y

Cited by 104 publications

(64 citation statements)

References 21 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Trend analyses for penile cancer seem less clear‐cut, some studies reporting a decrease, some no change and some an increase . Few studies have examined trends in penile cancer mortality and/or survival, but the existing evidence suggests that any changes for these outcomes are small and may also differ between geographical regions …”

Section: Introductionmentioning

confidence: 99%

Trends in incidence, mortality and survival of penile squamous cell carcinoma in Norway 1956–2015

Hansen

Orumaa

Lie

et al. 2017

Intl Journal of Cancer

View full text Add to dashboard Cite

We examine trends in incidence, mortality and survival of penile squamous cell carcinoma (SCC) in Norway over 60 years. Data on all cases of penile cancer diagnosed in Norway during 1956–2015 were obtained from the Cancer Registry of Norway. Trends in age‐standardized rates of penile SCC incidence, mortality and 5‐year relative survival were assessed by the annual percentage change statistic and joinpoint regression. A total of 1,596 penile cancer cases were diagnosed during 1956–2015, among which 1,474 (92.4%) were SCC. During 2011–2015, the age‐standardized incidence and mortality of penile SCC were 0.91 (95% confidence interval (CI): 0.78; 1.05) and 0.50 (0.42; 0.60) per 100,000, respectively, and the 5‐year relative survival was 61.6% (41.9; 76.4). The incidence of SCC increased during 1956–2015, with an average annual percentage change (AAPC) of 0.80% (0.46; 1.15). The increase was strongest among men diagnosed at a relatively early age (age<=64 years; AAPC: 1.47% (0.90; 2.05)). Mortality also increased over the study period (AAPC: 0.47% (0.10; 0.85)), whereas 5‐year relative survival did not change (AAPC: 0.08% (−0.19; 0.36)). We conclude that the incidence of penile SCC has increased at a moderate and constant rate during 1956–2015, and that the most consistent increase occurred among younger men. Mortality also increased during the study period. However, survival did not change, thus changes in diagnostics and treatment had little impact on survival from penile SCC. Since a substantial proportion of penile SCC is caused by human papillomavirus (HPV), the incidence increase may in part be attributed to increased exposure to HPV in the population.

show abstract

Section: Introductionmentioning

confidence: 99%

Trends in incidence, mortality and survival of penile squamous cell carcinoma in Norway 1956–2015

Hansen

Orumaa

Lie

et al. 2017

Intl Journal of Cancer

View full text Add to dashboard Cite

show abstract

“…In England, the incidence has increased by approximately 20% over the last 40 years [1], and there are now just over 500 cases annually in the United Kingdom. Penile cancer has a characteristic stepwise lymphatic dissemination pattern, first to the inguinal lymph nodes and then to the pelvic lymph nodes.…”

Section: Introductionmentioning

confidence: 99%

Investigating the role of SPECT/CT in dynamic sentinel lymph node biopsy for penile cancers

Saad

Omorphos

Michopoulou

et al. 2017

Eur J Nucl Med Mol Imaging

Self Cite

View full text Add to dashboard Cite

PurposeCurrently, most centres use 2-D planar lymphoscintigraphy when performing dynamic sentinel lymph node biopsy in penile cancer patients with clinically impalpable inguinal nodes. This study aimed to investigate the role of SPECT/CT following 2-D planar lymphoscintigraphy (dynamic and static) in the detection and localization of sentinel lymph nodes in the groin.MethodsA qualitative (visual) review was performed on planar followed by SPECT/CT lymphoscintigraphy in 115 consecutive patients (age 28–86 years) who underwent injection of 99mTc-nanocolloid followed by immediate acquisition of dynamic (20 min) and early static scans (5 min) initially and further delayed static (5 min) images at 120 min followed by SPECT/CT imaging. The lymph nodes detected in each groin on planar lymphoscintigraphy and SPECT/CT were compared.ResultsA total of 440 and 467 nodes were identified on planar scintigraphy and SPECT/CT, respectively. Overall, SPECT/CT confirmed the findings of planar imaging in 28/115 cases (24%). In the remaining 87 cases (76%), gross discrepancies were observed between planar and SPECT/CT images. SPECT/CT identified 17 instances of skin contamination (16 patients, 13%) and 36 instances of in-transit lymphatic tract activity (24 patients, 20%) that had been interpreted as tracer-avid lymph nodes on planar imaging. In addition, SPECT/CT identified 53 tracer-avid nodes in 48 patients (42%) that were not visualized on planar imaging and led to reclassification of the drainage basins (pelvic/inguinal) of 27 tracer-avid nodes.ConclusionsThe addition of SPECT/CT improved the rate of detection of true tracer-avid lymph nodes and delineated their precise (3-D) anatomic localization in drainage basins.

show abstract

“…Penile cancer is relatively rare in the developed world, but represents a global health problem, showing high prevalence and posing significant morbidity and mortality in developing countries (1,2). The age standardized incidence of penile cancer is 0.3-1.0 per 100,000 men in European countries and the United States, equating to approximately 1,600 new cases per annum in the United States (2).…”

Section: Introductionmentioning

confidence: 99%

Epigenetics Markers of Metastasis and HPV-Induced Tumorigenesis in Penile Cancer

Feber

Arya

Winter

et al. 2015

Clinical Cancer Research

Self Cite

View full text Add to dashboard Cite

Purpose: Penile cancer is a rare malignancy in the developed world with just more than 1,600 new cases diagnosed in the United States per year; however, the incidence is much higher in developing countries. Although HPV is known to contribute to tumorigenesis, little is known about the genetic or epigenetic alterations defining penile cancer.Experimental Design: Using high-density genome-wide methylation arrays, we have identified epigenetic alterations associated with penile cancer. Q-MSP was used to validate lymph node metastasis markers in 50 cases. A total of 446 head and neck squamous cell carcinoma (HNSCC) and cervical squamous cell carcinoma (CESCC) samples were used to validate HPV-associated epigenetic alterations.Results: We defined 6,933 methylation variable positions (MVP) between normal and tumor tissue, which includes 997 hypermethylated differentially methylated regions associated with tumor supressor genes, including CDO1, AR1, and WT1. Analysis of penile cancer tumors identified a 4 gene episignature which accurately predicted lymph node metastasis in an independent cohort (AUC of 89%). Finally, we explored the epigenetic alterations associated with penile cancer HPV infection and defined a 30 loci lineage-independent HPV specific epi-signature which predicts HPV status and survival in independent HNSCC, CESC cohorts. Epi-signature-negative patients have a significantly worse overall survival [HNSCC P ¼ 0.00073; 95% confidence interval (CI), 0.021-0.78; CESC P ¼ 0.0094; HR ¼ 3.91, 95% CI ¼ 0.13-0.78], HPV epi-signature is a better predictor of survival than HPV status alone.Conclusions: These data demonstrate for the first time genome-wide epigenetic events involved in an aggressive penile cancer phenotype and define the epigenetic alterations common across multiple HPV-driven malignancies.

show abstract

Long-term trends in incidence, survival and mortality of primary penile cancer in England

Cited by 104 publications

References 21 publications

Trends in incidence, mortality and survival of penile squamous cell carcinoma in Norway 1956–2015

Trends in incidence, mortality and survival of penile squamous cell carcinoma in Norway 1956–2015

Investigating the role of SPECT/CT in dynamic sentinel lymph node biopsy for penile cancers

Epigenetics Markers of Metastasis and HPV-Induced Tumorigenesis in Penile Cancer

Contact Info

Product

Resources

About