Abstract:Background-We examined whether population-level hospitalization rates for heart failure (HF) and subsequent survival have continued to improve since the turn of the century. We also examined trends in the prescribing of evidence-based pharmacological treatment for HF.
“…Advances in both the medical and device based treatments, have been associated with improved survival rates in patients with HF in many [17][18][19][20] but not all national registry-based studies. 21 Age-standardized death rates from heart failure have been reported to decrease by 40% in seven European countries between 1987 and 2008.…”
Aims: To evaluate whether the survival rates of patients with heart failure (HF) in the community are better than those with a diagnosis of the 4 most common cancers in men and women in a contemporary primary care cohort in Scotland.
Methods and Results:The data were obtained from the Primary Care Clinical Informatics Unit from a database of 1.75 million people registered with 393 general practices in Scotland. Sex-specific survival modeling was undertaken using Cox proportional hazards models, adjusted for potential confounders. A total of 56,658 patients were eligible to be included in the study with 147,938 person years follow up (median follow up 2.04 years). In men, heart failure (reference group; 5yrs survival 37.7%) had worse mortality outcomes than patients with prostate cancer (HR 0.61, 95%CI 0.57-0.65; 5yrs survival 49.0%), and bladder cancer (HR 0.88, 95%CI 0.81-0.96; 5yrs survival 36.5%), but better than lung cancer (HR 3.86, 95%CI 3.65-4.07; 5yrs survival 2.8%) and colorectal cancer (HR 1.23 95%CI 1.16-1.31; 5 yrs survival 25.9%). In women, patients with HF (reference group; 5yrs survival 31.9%) had worse mortality outcomes than patients with breast cancer (HR 0.55 95%CI 0.51-0.59; 5yrs survival 61.0%), but better outcomes than lung cancer (HR 3.82, 95%CI 3.60-4.05; 5yrs survival 3.6%), ovarian cancer (HR 1.98, 95%CI 1.80-2.17; 5yrs survival 19%) and colorectal cancer (HR 1.21, 95%CI 1.13-1.29; 5yrs survival 28.4%).
Conclusions:Despite advances in management, heart failure remains as 'malignant' as some of the common cancers in both men and women.3
“…Advances in both the medical and device based treatments, have been associated with improved survival rates in patients with HF in many [17][18][19][20] but not all national registry-based studies. 21 Age-standardized death rates from heart failure have been reported to decrease by 40% in seven European countries between 1987 and 2008.…”
Aims: To evaluate whether the survival rates of patients with heart failure (HF) in the community are better than those with a diagnosis of the 4 most common cancers in men and women in a contemporary primary care cohort in Scotland.
Methods and Results:The data were obtained from the Primary Care Clinical Informatics Unit from a database of 1.75 million people registered with 393 general practices in Scotland. Sex-specific survival modeling was undertaken using Cox proportional hazards models, adjusted for potential confounders. A total of 56,658 patients were eligible to be included in the study with 147,938 person years follow up (median follow up 2.04 years). In men, heart failure (reference group; 5yrs survival 37.7%) had worse mortality outcomes than patients with prostate cancer (HR 0.61, 95%CI 0.57-0.65; 5yrs survival 49.0%), and bladder cancer (HR 0.88, 95%CI 0.81-0.96; 5yrs survival 36.5%), but better than lung cancer (HR 3.86, 95%CI 3.65-4.07; 5yrs survival 2.8%) and colorectal cancer (HR 1.23 95%CI 1.16-1.31; 5 yrs survival 25.9%). In women, patients with HF (reference group; 5yrs survival 31.9%) had worse mortality outcomes than patients with breast cancer (HR 0.55 95%CI 0.51-0.59; 5yrs survival 61.0%), but better outcomes than lung cancer (HR 3.82, 95%CI 3.60-4.05; 5yrs survival 3.6%), ovarian cancer (HR 1.98, 95%CI 1.80-2.17; 5yrs survival 19%) and colorectal cancer (HR 1.21, 95%CI 1.13-1.29; 5yrs survival 28.4%).
Conclusions:Despite advances in management, heart failure remains as 'malignant' as some of the common cancers in both men and women.3
“…Available online June 2, 2010. Published June 11, 2010. Heart failure (HF) is an important cause of mortality and hospitalization in Brazil and worldwide and, despite recent advances in the medical treatment of HF, mortality rates and morbidity due to this entity remain elevated (1)(2)(3)(4). Identification of prognostic factors is an important aspect of HF management that has been the focus of intense clinical and basic research (5,6).…”
“…Encouragingly progress continues as new pharmacological therapies further improve the prognosis of patients with HF over and above best current treatment [2]. Yet translating these successes into meaningful gains in population level prognosis has been difficult [3]. A number of factors are responsible.…”
mentioning
confidence: 99%
“…At the same time we have witnessed a change in the epidemiology of HF. The aging population coupled with better secondary prevention in those with coronary heart disease have conspired to increase the incidence of HF and the age at which people first develop HF [3]. Despite this there are encouraging reports from across the globe that in developed countries the incidence of HF is falling [3,5], another success.…”
mentioning
confidence: 99%
“…The aging population coupled with better secondary prevention in those with coronary heart disease have conspired to increase the incidence of HF and the age at which people first develop HF [3]. Despite this there are encouraging reports from across the globe that in developed countries the incidence of HF is falling [3,5], another success. While we assimilate the information from clinical trials, registries and epidemiological studies to build a contemporary picture of HF, few studies are able to provide a comprehensive overview of HF.…”
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