Long-term treatment with supraphysiological doses of nandrolone decanoate reduces the sensitivity of Bezold–Jarisch reflex control of heart rate and blood pressure

Bissoli, Nazaré Souza; Medeiros, Ana Raquel Santos; Santos, Maria Carmen S.; Busato, Vera Cristina W.; Jarske, Robson Dettman; Abreu, Gláucia Rodrigues de; Moysés, Margareth Ribeiro; Andrade, Tadeu Uggere de

doi:10.1016/j.phrs.2009.03.001

Cited by 34 publications

(22 citation statements)

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“…After one week habituation, animals were divided into 4 male, female control, and test groups (N = 10) as follow: Male and female test groups which received supraphysiological dose of (15 mg/kg im) ND daily for 2 weeks but male and female control groups received the same volume of peanut oil (oil vehicle) during the test period [17].…”

Section: Methodsmentioning

confidence: 99%

The Effects of Subacute Supraphysiological Dose of Nandrolone Decanoate on Liver Enzymes and Lipid Pofiles in Rats

Shahraki

Rafeei

2015

Zahedan J Res Med Sci

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Background: Nandrolone decanoate (ND) is a doping agent which is used by athletes and has a lot of adverse effects on the body. Objectives: This survey was carried out to evaluate the effects of subacute supraphysiological dose of ND administration on liver enzymes and lipid profiles in male and female rats. Materials and Methods: This experimental study was performed on 40 Wistar-Albino rats, which after weighing divided into 4 groups as control (female and male) and test (female and male) groups (N = 10). The test groups received 15 mg/kg nandrolone decanoate by intra muscular (im) injection for 2 weeks, but control groups received the same volum of oil vehicle. At the end, animals were deeply anesthetized by diethyl ether, scarified and their blood samples were collected. Liver enzymes and lipoproteins were measured by usual methods. Obtained data were analyzed by SPSS-15, applying ANOVA and Tukey tests. Results were expressed as mean ± SD. Statistical difference was recognized significant by P ≤ 0.05. Results: Results showed that AST value in the test groups were significantly increased compared to those of the control groups. In addition, HDL and cholesterol values in female test group were significantly increased compared to those of male test group. Moreover, final weight, food, and water intake in all test groups were significantly increased compared to those of control groups. Conclusions: These results indicated that subacute administration of nandrolone decanoate alters liver enzymes, lipoprotein profile, final weight, food, and water intake in rats. The exact mechanism needs future studies.

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Section: Methodsmentioning

confidence: 99%

The Effects of Subacute Supraphysiological Dose of Nandrolone Decanoate on Liver Enzymes and Lipid Pofiles in Rats

Shahraki

Rafeei

2015

Zahedan J Res Med Sci

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“…Regarding the effect of chronic administration of nandrolone and exercise on HR, most of similar studies reported lack of significant effect of exercise (46,47,49) or chronic administration of nandrolone (48,50) on HR of rats. Soares et al (29) reported insignificant effect of exercise and nandrolone, alone or in combination, on HR of rats.…”

Section: Discussionmentioning

confidence: 99%

Nandrolone plus moderate exercise increases the susceptibility to lethal arrhythmias

Joukar¹,

Baravati²,

Fathpour³

et al. 2015

Res Cardiovasc Med

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Background: Until now, no experimental study has directly assessed the arrhythmogenesis of chronic consumption of anabolic androgenic steroids along with moderate-intensity endurance exercise. Objectives: We evaluated the influence of integration of anabolic androgenic steroids along with moderate-intensity endurance exercise on susceptibility to lethal ventricular arrhythmias in rat. Materials and Methods:The animal groups were as follows: control group (CTL); exercise group (EX) which were under 6 weeks of treadmill exercise; nandrolone group (Nan) which received 5 mg/kg of nandrolone decanoate twice a week; vehicle group (Arach) which received Arachis oil (solvent of nandrolone); trained vehicle group (Arach + Ex); and trained nandrolone group (Nan + Ex). One day after ending of the intervention period, arrhythmia was inducted by intravenous infusion of aconitine and ventricular arrhythmias were recorded. Then malondialdehyde (MDA) and glutathione peroxidase (GPX) of heart tissue were measured. Results: Nandrolone, exercise, and their combination were associated with heart hypertrophy. Exercise could prevent the incremental effect of nandrolone on MDA/GPX ratio. Chronic administration of nandrolone with moderate-intensity endurance exercise had no significant effect on blood pressure, heart rate, and basal electrocardiographic parameters. Combination of nandrolone and exercise significantly increased the incidence of ventricular fibrillation (VF) and reduced the VF latency (P < 0.05). Conclusions:The findings suggest that chronic coadministration of nandrolone with moderate-intensity endurance exercise facilitates the VF occurrence in rat. Complementary studies are needed to elucidate the involved mechanisms of this abnormality.

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“…Besides the testosterone-induced effects on baroreflex, this sexual hormone may also modulate the cardiopulmonary reflex and the chemoreflex. Bissoli et al (2009) demonstrated that long-term treatment (8 weeks) with supraphysiological doses of nandrolone decanoate reduces the sensitivity of BJR control of HR in male rats. The effects of testosterone on BJR seem to be time-dependent, since the same treatment for 4 weeks had no effects on BJR nor the basal HR (Andrade et al, 2008).…”

Section: Testosteronementioning

confidence: 95%

Neurohumoral Control of Heart Rate

Graceli¹,

Pedrosa²,

Gava³

2012

Cardiac Arrhythmias - New Considerations

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Long-term treatment with supraphysiological doses of nandrolone decanoate reduces the sensitivity of Bezold–Jarisch reflex control of heart rate and blood pressure

Cited by 34 publications

References 50 publications

The Effects of Subacute Supraphysiological Dose of Nandrolone Decanoate on Liver Enzymes and Lipid Pofiles in Rats

The Effects of Subacute Supraphysiological Dose of Nandrolone Decanoate on Liver Enzymes and Lipid Pofiles in Rats

Nandrolone plus moderate exercise increases the susceptibility to lethal arrhythmias

Neurohumoral Control of Heart Rate

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