Long-term treatment outcome of oral premalignant lesions

Holmstrup, Palle; Vedtofte, Poul; Reibel, Jesper; Stoltze, Kaj

doi:10.1016/j.oraloncology.2005.08.011

Cited by 399 publications

(468 citation statements)

References 51 publications

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“…The association between the grade of epithelial dysplasia and OSCC development is supported by several other studies [1,3,4,23]. It is important to note that patients with mild dysplasia may develop OSCC [9].…”

Section: Discussionsupporting

confidence: 58%

“…The current best practice of care is to remove these lesions for histologic analysis. The presence of epithelial dysplasia, albeit with well-documented limitations, is still the gold standard in evaluating the malignant potential of suspicious lesions of the oral mucosa [1][2][3][4]. It is also well-documented that a number of PMDs, regardless of the presence of dysplasia, do not progress to carcinoma [5].…”

Section: Introductionmentioning

confidence: 99%

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Correlation Between Dysplasia and Ploidy Status in Oral Leukoplakia

Zyl

Heerden

Langenegger

et al. 2012

Head and Neck Pathol

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Oral leukoplakia and other potentially malignant disorders (PMD) may progress to oral squamous cell carcinoma (OSCC). The gold standard for assessing the potential for malignant transformation remains histologic examination with the aim of grading the dysplastic changes. However, not all lesions with dysplasia will progress to OSCC. DNA ploidy has been suggested as a method to predict the clinical behaviour of PMD. This study reports on the use of high-resolution flow cytometry to determine the ploidy status of formalin-fixed, paraffin-embedded material from PMD compared to their dysplasia grade on histology. Aneuploidy was found in 13 % of mild, 31 % of moderate, and 54 % of severe dysplasia cases. This difference was statistically significant (p = 0.011). The differences in ploidy status were more significant when grouping the dysplasia into low-risk and high-risk categories (p = 0.008). These findings indicate that the ploidy status of PMD as determined by high-resolution flow cytometry may be of value in predicting biological behaviour in PMD such as leukoplakia.

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Section: Discussionsupporting

confidence: 58%

Section: Introductionmentioning

confidence: 99%

Correlation Between Dysplasia and Ploidy Status in Oral Leukoplakia

Zyl

Heerden

Langenegger

et al. 2012

Head and Neck Pathol

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“…Oral epithelial dysplasia is considered by many (Holmstrup et al, 2006;Arduino et al, 2009) and there is some controversy as to the best dysplasia grading system to employ. In the present study, epithelial dysplasia (mild) was found in one patient with lichenoid lesion.…”

Section: Discussionmentioning

confidence: 99%

Oral Potentially Malignant Disorders among Dental Patients: a Pilot Study in Jordan

Hassona¹,

Scully²,

Almangush³

et al. 2015

Asian Pacific Journal of Cancer Prevention

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Background: To determine the prevalence, types, and risk factors of oral potentially malignant disorders (OPMDs) among a group of Arab Jordanian dental patients, and to evaluate their awareness and attitudes toward early diagnosis and treatment. Materials and Methods: A total of 1,041 patients attending a University Hospital for dental care were examined for the presence of OPMDs. Histopathological examination was performed on all cases clinically diagnosed and patients were directly interviewed to evaluate their knowledge and attitudes toward early detection and treatment of oral cancer. Results: The prevalence of OPMDs overall was 2.8%. Lichen planus/lichenoid lesions were the most common lesions (1.8%) followed by leukoplakias (0.48%), chronic hyperplastic candidiosis (0.38%), and erythroplakia (0.096%). Smoking, alcohol, and age (>40 years) were the main identifiable risk factors. Patients with OPMDs displayed a general lack of awareness and negative attitudes towards early diagnosis and treatment. Conclusions: OPMDs among Arab dental patients are relatively uncommon and awareness about oral cancer among Jordanian dental patients is low. Interventions to improve public knowledge about oral cancer and attitudes toward early diagnosis and treatment are urgently indicated.

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“…In cases diagnosed as speckled leukoplakia, histopathological study showed mild and severe dysplasia, and in erythroplakia cases, its histopathologic diagnosis was mild epithelial dysplasia, severe epithelial dysplasia, and one case of SCC. A study conducted, in 2006, by Holmstrup et al [14] showed, out of 236 patients, there were 39 cases of homogenous Erythroplakia is defined as ''A fiery red patch that cannot be characterized clinically or pathologically as any other definable disease." The clinical presentation may be flat or depressed with a smooth or granular surface.…”

Section: Discussionmentioning

confidence: 99%

Leukoplakia and erythroplakia: A clinicians perspective and histopathologist verdict - A retrospective study

Sreelatha¹,

Chuppa²,

Bharati³

et al. 2016

JCRI

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Background: Precancerous lesions and conditions which are replaced by the term potentially malignant disorders (PMDs) may precede oral cancer. The PMDs present as visible clinical changes may belie the true nature of the lesion. Histopathologic diagnosis is the gold standard in evaluating these lesions for dysplasia and malignant potential. The aim of the present study is to evaluate the clinicopathological findings of oral leukoplakia and erythroplakia. Materials and Methods: Pathological report of cases, which were clinically diagnosed as leukoplakia and erythroplakia, were studied retrospectively from 2013 to 2015.

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Long-term treatment outcome of oral premalignant lesions

Cited by 399 publications

References 51 publications

Correlation Between Dysplasia and Ploidy Status in Oral Leukoplakia

Correlation Between Dysplasia and Ploidy Status in Oral Leukoplakia

Oral Potentially Malignant Disorders among Dental Patients: a Pilot Study in Jordan

Leukoplakia and erythroplakia: A clinicians perspective and histopathologist verdict - A retrospective study

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