Long-Term Treatment of Nasal Polyps With Beclomethasone Dipropionate Aerosol II. Clinical Results

Pedersen, Carsten; Mygind, Niels; Sørensen, H.; Prytz, S.

doi:10.3109/00016487609120898

Cited by 31 publications

(9 citation statements)

References 2 publications

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“…DISCUSSION Topical glucocorticoids have been used successfully for a long time in the treatment of NPs, and are known to lead to improvement in clinical symptoms, nasal peak flow, and size of NPS. 7 Kanai et all re-P< .05 II n.s. 250 -ported that clinical improvement might result from reduction of activated eosinophi1sand T lymphocytes within NPs.…”

Section: Inhibitory Effects Of Dex On Gm-csf Production By Npecsmentioning

confidence: 95%

Effects of Glucocorticoids on Infiltrating Cells and Epithelial Cells of Nasal Polyps

Watanabe¹,

Kanaizumi²,

Shirasaki³

et al. 2004

Ann Otol Rhinol Laryngol

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Glucocorticoids are known to be effective in the treatment of nasal polyps (NPs). To examine the mechanisms of their effect, we evaluated 1) the ability of glucocorticoids to induce the apoptosis of eosinophils and T lymphocytes in NPs, and 2) the ability of dexamethasone to down-regulate epithelial cell functions that relate to eosinophilic inflammation. In vitro and in vivo, glucocorticoids increased the apoptosis of both eosinophils and T lymphocytes in NPs. Dexamethasone inhibited the production of granulocyte-macrophage colony-stimulating factor (GM-CSF) from both NP epithelial cells that were unstimulated and NP epithelial cells that were stimulated with interleukin-4 or tumor necrosis factor alpha. These results suggest that the clinical efficacy of glucocorticoids on NPs may be due to 1) induction of apoptosis in both eosinophils and T lymphocytes that infiltrate NPs, and 2) down-regulation of epithelial GM-CSF production, which prolongs eosinophil survival.

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Section: Inhibitory Effects Of Dex On Gm-csf Production By Npecsmentioning

confidence: 95%

Effects of Glucocorticoids on Infiltrating Cells and Epithelial Cells of Nasal Polyps

Watanabe¹,

Kanaizumi²,

Shirasaki³

et al. 2004

Ann Otol Rhinol Laryngol

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“…Many studies have investigated the symptomatic efficacy of intranasal corticosteroids such as beclomethasone dipropionate and budesonide in patients with nasal polyposis. A Danish study conducted in 1975 demonstrated the efficacy of beclomethasone &propionate, compared with placebo, in reducing the seventy of nasal symptoms (16,17) [Fig. 3 ) .…”

Section: Lntranasal Corticosteroidssymptomatic Efficacymentioning

confidence: 99%

3. Advances in the medical treatment of nasal polyps

Mygind

1999

Allergy

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The objectives of the medical management of nasal polyposis are to eliminate or reduce the size of polyps, re-establish nasal breathing, reduce symptoms of rhinitis, restore the sense of smell and prevent the recurrence of nasal polyps. Corticosteroids have a proven therapeutic effect on the symptoms of nasal polyposis and may reduce one of the underlying causes of polyps, inflammation. The efficacy of topical corticosteroids such as beclomethasone dipropionate nasal spray and betamethasone nasal drops in reducing polyp size and rhinitis symptoms has been demonstrated in several randomized, placebo-controlled trials. Flunisolide and budesonide have also been shown to delay the recurrence of polyps after surgery. Topical corticosteroids can be used as long-term therapy either alone in mild cases, or combined with systemic corticosteroids and/or surgery in severe cases. Most patients will respond well to topical corticosteroid treatment of their nasal polyposis; consequently, the requirement for repetitive nasal surgery will be reduced.

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“…Corticosteroids, both systemic 1,2 and topical, 3 in the form of nasal drops 4 or spray have been demonstrated to be an effective drug in the treatment of nasal polyps and the prevention of their regrowth after surgery 5 …”

Section: Introductionmentioning

confidence: 99%

Do corticosteroids induce apoptosis in nasal polyp inflammatory cells? in vivo and in vitro studies

et al. 1999

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Long-Term Treatment of Nasal Polyps With Beclomethasone Dipropionate Aerosol II. Clinical Results

Cited by 31 publications

References 2 publications

Effects of Glucocorticoids on Infiltrating Cells and Epithelial Cells of Nasal Polyps

Effects of Glucocorticoids on Infiltrating Cells and Epithelial Cells of Nasal Polyps

3. Advances in the medical treatment of nasal polyps

Do corticosteroids induce apoptosis in nasal polyp inflammatory cells? in vivo and in vitro studies

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