Long term treatment of moderate hypertension with the beta1-receptor blocking agent metoprolol

Hansson, Björn; Jf, Dymling; Hedeland, H; Ul, Hulthén

doi:10.1007/bf00607671

Cited by 60 publications

(7 citation statements)

References 32 publications

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“…These findings Indicate that either an Increase In stroke volume or arterlo-venous oxygen difference had to occur to maintain exercise capacity. These findings are In agreement with other studies (34,49,78). However, other reports Indicate t h a t beta-adrenergic blockade may decrease exercise tolerance and maximal oxygen consunptIon (10, 25,29,64,72).…”

Section: Discussionsupporting

confidence: 94%

The Effect of Propranolol on the Training Response to Endurance Exercise in Normal Human Adults

Cleary

Kirby

Shook

et al. 1985

Medicine & Science in Sports & Exercise

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INFORMATION T O USERSThis re p ro d u c tio n was m ad e from a copy of a d o cu m en t sent to us f o r microfilming. While th e m o st advanced technology has b e e n used to photograph a n d reproduce this d o c u m e n t, the q u ality o f the reproduction is heavily d e p e n d e n t upon the quality o f th e material su b m itte d .The fo llo w in g explanation o f techniques is pro v id ed to help c la rify markings or notations w h ich may ap p ear o n this reproduction.1 .T h e sign or "ta rg e t" fo r pages a p p a re n tly lacking from th e document p h o to g rap h ed is " M issing Page(s)". If it w as possible to o b ta in the missing p ag e(s) o r section, th e y are spliced into th e film along with a d ja c e n t pages. This m ay have necessitated cu ttin g through an im age and duplicating adjacent pages to a ssu re complete c o n tin u ity .2. W hen an image on th e film is obliterated w ith a round b lack m ark, it is an in d ic a tio n of either blurred copy b ec au se o f movement d u rin g exposure, d u p lic a te copy, or copyrighted materials t h a t should not have b e e n filmed. For b lu rre d pages, a good im age of the page c a n be found in the a d ja c e n t frame. If c o p y rig h te d materials w ere deleted, a ta rg e t n o te will appear lis tin g the pages in th e a d ja c e n t frame.3. W hen a map, drawing o r chart, etc., is p a r t o f the material being photographed, a d e fin ite method o f " sectioning" th e m aterial has been follow ed. It is c u s to m a ry to begin film in g at the upper l e f t hand comer of a la rg e sheet and to c o n tin u e from left to rig h t in equal se c tio n s with small overlaps. I f necessary, se c tio n in g is continued again-beginning b e lo w the first row a n d continuing on u n til com plete.4. F o r illustrations th a t cannot be satisfacto rily reproduced b y xerographic m e a n s, photographic p rin ts can be p u rc h a se d at additional c o s t and inserted in to y o u r xerographic copy. These prints a re available upon r e q u e s t from the D issertatio n s Custom er Services D epartm ent.5. S om e pages in any d o c u m e n t may have indistinct print. In all cases the best availab le copy has been filmed.

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Section: Discussionsupporting

confidence: 94%

The Effect of Propranolol on the Training Response to Endurance Exercise in Normal Human Adults

Cleary

Kirby

Shook

et al. 1985

Medicine & Science in Sports & Exercise

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“…Plasma renin activity decreased in all except the case with polycystic kidneys (Hansson et al 1977). Seven were con¬ sidered to have essential hypertension, one had polycystic kidney disease.…”

Section: Methodsmentioning

confidence: 90%

Effect of Insulin Induced Hypoglycaemia on the Blood Levels of Catecholamines, Glucagon, Growth Hormone, Cortisol, C-Peptide and Proinsulin Before and During Medication With the Cardioselective Beta-Receptor Blocking Agent Metoprolol in Man

Hökfelt

Hansson

Hedïng

et al. 1978

Acta Endocrinologica

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Studies were performed in 8 males with moderate hypertension to explore the influence of metoprolol on the sensitivity to insulin and on the response to hypoglycaemia with respect to plasma catecholamines, glucagon, growth hormone and cortisol. C-peptide and proinsulin were determined in some instances. All subjects were studied before treatment, after one month on placebo and after 3 months on metoprolol. The final maximal dose used was 50\p=n-\150 mg three times daily. The sensitivity to insulin was the same during all three conditions studied. The response in catecholamines, glucagon, growth hormone and cortisol following insulin induced hypoglycaemia was similar during placebo as compared to no treatment. Adrenaline, growth hormone and cortisol showed a greater response to hypoglycaemia during metoprolol whereas no difference was seen with respect to noradrenaline and glucagon. The half-life of exogenous insulin was the same before and during metoprolol (7.6 min). Metoprolol caused no changes in the basal C-peptide levels. During the hypoglycaemic phase C-peptide showed a continuous gradual fall, which was similar before and during metoprolol. Proinsulin was below the lower limit of detection before and following the injection of insulin both without treatment and during metoprolol.

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“…pertension,": 7 we recorded blood pressure levels in patients given dosages up to 600 mg daily to determine the most effective daily dose.…”

mentioning

confidence: 99%

Metoprolol kinetics and dose response in hypertensive patients

Myers

Thiessen

1980

Clin Pharmacol Ther

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The kinetics and dose-response characteristics of metoprolol were examined in a series of hypertensive patients. In 14 the elimination half-life of metoprolol after single 100-mg doses (4.1 +/- 0.6 hr) was prolonged (p less than 0.05) after 6 to 12 wk of therapy (5.6 +/- 0.7 hr). In 5 patients receiving 100 mg twice daily evidence of nonlinear metoprolol kinetics emerged, because the area under the concentration-time curve at steady state was 86.8% more (p less than 0.02) than predicted from a single dose. Kinetic data from single doses of metoprolol appear to be a poor predictor of steady-state kinetics. Single metoprolol dosage also induced a fall (p less than 0.01) in blood pressure with pretreatment levels (163/108), reaching a minimum at 5 hr (133/189). During long-term therapy incremented doses of metoprolol between 100 and 600 mg/day in 34 hypertensive patients resulted in a relatively horizontal dose-response curve at doses above 200 mg/day.

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Long term treatment of moderate hypertension with the beta1-receptor blocking agent metoprolol

Cited by 60 publications

References 32 publications

The Effect of Propranolol on the Training Response to Endurance Exercise in Normal Human Adults

The Effect of Propranolol on the Training Response to Endurance Exercise in Normal Human Adults

Effect of Insulin Induced Hypoglycaemia on the Blood Levels of Catecholamines, Glucagon, Growth Hormone, Cortisol, C-Peptide and Proinsulin Before and During Medication With the Cardioselective Beta-Receptor Blocking Agent Metoprolol in Man

Metoprolol kinetics and dose response in hypertensive patients

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