Long-term treatment and suicidal behavior in severe depression: ECT and antidepressant pharmacotherapy may have different effects on the occurrence and seriousness of suicide attempts

Brådvik, Louise; Berglund, Mats

doi:10.1002/da.20134

Cited by 23 publications

(30 citation statements)

References 37 publications

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“…Adequate treatment of depressive episodes with antidepressant pharmacotherapy and ECT was similar throughout the course of depression in suicides and controls and so was improvement, as has been described in a previous paper (Brådvik & Berglund, 2006). There were also similar low rates of Lithium treatment, mainly for bipolar I.…”

Section: Course Of Depressionsupporting

confidence: 55%

Depressive Episodes with Suicide Attempts in Severe Depression: Suicides and Controls Differ Only in the Later Episodes of Unipolar Depression

Brådvik

Berglund

2010

Archives of Suicide Research

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The aim of the present study was to investigate the distribution of suicide attempts across the depressive episodes in suicides and controls with a severe depression. A blind record evaluation was performed of 100 suicide victims and matched controls admitted to the Department of Psychiatry between 1956 and 1969 and monitored to 2006. There was a similar number of episodes in suicides and controls and in the early episodes a similar number of suicide attempts in both groups. However, in the later episodes future suicides showed more suicide attempts as compared to controls. This was found for unipolar depression only. This difference was found despite previously shown similar rates of adequate treatment and improvement. In conclusion, more depressive episodes including suicide attempts appeared to be related to suicide.

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Section: Course Of Depressionsupporting

confidence: 55%

Depressive Episodes with Suicide Attempts in Severe Depression: Suicides and Controls Differ Only in the Later Episodes of Unipolar Depression

Brådvik

Berglund

2010

Archives of Suicide Research

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“…It may be a coincidence, but it could also indicate an effect of ECT on suicidality. 30 We need further studies on the effect of different regimens of combined pharmacotherapy and ECT on the risk for suicide attempts and suicide, including the benefit and risks of lithium therapy.…”

Section: Discussionmentioning

confidence: 99%

Continuation Electroconvulsive Therapy With Pharmacotherapy Versus Pharmacotherapy Alone for Prevention of Relapse of Depression

Nordenskjöld¹,

Knorring²,

Ljung³

et al. 2013

The Journal of ECT

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“…In a subsequent study, the same researchers also found that while suicide attempts were, overall, less frequent after ECT than after antidepressant drugs, there were significantly more severe suicide attempts (defined as highly lethal suicide attempts, (i.e. requiring intensive care) following ECT than following antidepressants (Bradvik & Berglund, 2006).…”

Section: Does Ect Prevent Suicide?mentioning

confidence: 93%

The effectiveness of electroconvulsive therapy: A literature review

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Bentall²

2010

Epidemiol Psychiatr Sci

105

113

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SUMMARYAim – To review the literature on the efficacy of electroconvulsive therapy [ECT], with a particular focus on depression, its primary target group. Methods – PsycINFO, Medline, previous reviews and meta-analyses were searched in an attempt to identify all studies comparing ECT with simulated-ECT [SECT]. Results – These placebo controlled studies show minimal support for effectiveness with either depression or ‘schizophrenia’ during the course of treatment (i.e. only for some patients, on some measures, sometimes perceived only by psychiatrists but not by other raters), and no evidence, for either diagnostic group, of any benefits beyond the treatment period. There are no placebo-controlled studies evaluating the hypothesis that ECT prevents suicide, and no robust evidence from other kinds of studies to support the hypothesis. Conclusions – Given the strong evidence (summarised here) of persistent and, for some, permanent brain dysfunction, primarily evidenced in the form of retrograde and anterograde amnesia, and the evidence of a slight but significant increased risk of death, the cost-benefit analysis for ECT is so poor that its use cannot be scientifically justified.Declaration of Interest: Neither author has any financial conflicts of interest in relation to this paper.

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Long-term treatment and suicidal behavior in severe depression: ECT and antidepressant pharmacotherapy may have different effects on the occurrence and seriousness of suicide attempts

Cited by 23 publications

References 37 publications

Depressive Episodes with Suicide Attempts in Severe Depression: Suicides and Controls Differ Only in the Later Episodes of Unipolar Depression

Depressive Episodes with Suicide Attempts in Severe Depression: Suicides and Controls Differ Only in the Later Episodes of Unipolar Depression

Continuation Electroconvulsive Therapy With Pharmacotherapy Versus Pharmacotherapy Alone for Prevention of Relapse of Depression

The effectiveness of electroconvulsive therapy: A literature review

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