Long-term tracking of cells using inorganic nanoparticles as contrast agents: are we there yet?

Taylor, Arthur; Wilson, Katie; Murray, Patricia; Fernig, David G.; Lévy, Raphaël

doi:10.1039/c2cs35031a

Cited by 160 publications

(166 citation statements)

References 67 publications

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“…In recent years, synthesis and conjugation of nanoparticles (NPs) have experienced a rapid evolution making possible advanced medical applications such as carriers for drug delivery [1,2], contrast agents for imaging [3], and radiosensitizers for radiotherapy [4] among others. However, this rapid evolution is often linked to an incomplete characterization or a lack of understanding on the mechanisms involved on the final application.…”

Section: Introductionmentioning

confidence: 99%

The role of PEG conformation in mixed layers: from protein corona substrate to steric stabilization avoiding protein adsorption

Comenge¹

2015

ScienceOpen Research

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Although nanoparticles (NPs) have been traditionally modified with a single ligand layer, mixture of ligands might help to combine different functionalities and to further engineer the NP surface. A detailed study of the competition between an alkanethiol (11-mercaptoundecanoic acid) and SH-PEG for the surface of AuNPs and the resultant behaviors of this model nanoconjugate is presented here. As a result, the physicochemical properties of these conjugates can be progressively tuned by controlling the composition and especially the conformation of the mixed monolayer. This has implications in the physiological stability. The controlled changes on the SH-PEG conformation rather than its concentration induce a change in the stabilization mechanism from electrostatic repulsion to steric hindrance, which changes the biological fate of NPs. Importantly, the adsorption of proteins on the conjugates can be tailored by tuning the composition and conformation of the mixed layer.

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Section: Introductionmentioning

confidence: 99%

The role of PEG conformation in mixed layers: from protein corona substrate to steric stabilization avoiding protein adsorption

Comenge¹

2015

ScienceOpen Research

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“…Common isotopes that can be chelated on to or incorporated within NPs (in an analogous way to the gadolinium ions used for MRI) include 18 F, 11 C, 15 O, 13 N, 64 Cu, 124 I, 68 Ga, 82 Rb, and 86 Y. PET imaging using 18 F, which is the most widespread radionuclide probe used in this field, has become an established clinical tool for whole-body imaging.…”

Section: Radionuclide Labeled Nanoparticlesmentioning

confidence: 99%

“…They are used to improve the enhancement of image contrast as compared to molecular species and improve the visibility of features that would otherwise be difficult to detect. They go on receiving considerable attention in this field for their potential as contrast agents, [2][3][4][5][6][7][8][9] offering many advantages compared to more conventional chemical agents such as greater biocompatibility and reduced toxicity [8,[10][11][12][13].…”

Section: Introductionmentioning

confidence: 99%

Functionalized nanomaterials: their use as contrast agents in bioimaging: mono- and multimodal approaches

Trequesser¹,

Seznec²,

Delville³

2016

Nano Online

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The successful development of nanomaterials illustrates the considerable interest in the development of new molecular probes for medical diagnosis and imaging. Substantial progress was made in synthesis protocol and characterization of these materials whereas toxicological issues are sometimes incomplete. Nanoparticle-based contrast agents tend to become efficient tools for enhancing medical diagnostics and surgery for a wide range of 2 imaging modalities. Multimodal nanoparticles (NPs) are much more efficient than conventional molecular-scale contrast agents. They provide new abilities for in vivo detection and enhanced targeting efficiencies through longer circulation times, designed clearance pathways, and multiple binding capacities. Properly protected, they can safely be used for the fabrication of various functional systems with targeting properties, reduced toxicity and proper removal from the body. This review mainly describes the advances in the development of mono-to multimodal NPs and their in vitro and in vivo relevant biomedical applications ranging from imaging and tracking to cancer treatment. Besides specific applications for classical imaging, (MRI, PET, CT, US, PAI) are also mentioned less common imaging techniques such as terahertz molecular imaging (THMI) or ion beam analysis (IBA).Perspectives on multimodal theranostic NPs and their potential for clinical advances are also mentioned.

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“…Common isotopes that can be chelated onto or incorporated within NPs (in an analogous way to the gadolinium ions used for MRI) include 18 F, 11 C, 15 O, 13 N, 64 Cu, 124 I, 68 Ga, 82 Rb, and 86 Y. PET imaging using 18 F, which is the most widespread radionuclide probe used in this field, has become an established clinical tool for whole-body imaging.…”

Section: Radionuclide Labeled Nanoparticlesmentioning

confidence: 99%

Functionalized nanomaterials: their use as contrast agents in bioimaging: mono- and multimodal approaches

Trequesser¹,

Seznec²,

Delville

2013

Nanotechnology Reviews

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Abstract:The successful development of nanomaterials illustrates the considerable interest in the development of new molecular probes for medical diagnosis and imaging. Substantial progress was made in the synthesis protocol and characterization of these materials, whereas toxicological issues are sometimes incomplete. Nanoparticlebased contrast agents (CAs) tend to become efficient tools for enhancing medical diagnostics and surgery for a wide range of imaging modalities. The multimodal nanoparticles (NPs) are much more efficient than the conventional molecular-scale CAs. They provide new abilities for in vivo detection and enhanced targeting efficiencies through longer circulation times, designed clearance pathways, and multiple binding capacities. Properly protected, they can safely be used for the fabrication of various functional systems with targeting properties, reduced toxicity, and proper removal from the body. This review mainly describes the advances in the development of mono-to multimodal NPs and their in vitro and in vivo relevant biomedical applications ranging from imaging and tracking to cancer treatment. Besides the specific applications for classical imaging (magnetic resonance imaging, positron emission tomography, computed tomography, ultrasound, and photoacoustic imaging), the less common imaging techniques such as terahertz molecular imaging (THMI) or ion beam analysis (IBA) are mentioned. The perspectives on the multimodal theranostic NPs and their potential for clinical advances are also mentioned.

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Long-term tracking of cells using inorganic nanoparticles as contrast agents: are we there yet?

Cited by 160 publications

References 67 publications

The role of PEG conformation in mixed layers: from protein corona substrate to steric stabilization avoiding protein adsorption

The role of PEG conformation in mixed layers: from protein corona substrate to steric stabilization avoiding protein adsorption

Functionalized nanomaterials: their use as contrast agents in bioimaging: mono- and multimodal approaches

Functionalized nanomaterials: their use as contrast agents in bioimaging: mono- and multimodal approaches

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