Long-term tracking and population characteristics of lipoprotein (a) in the Cardiovascular Risk in Young Finns Study

Raitakari, Olli T.; Kivelä, Annukka M.; Pahkala, Katja; Rovio, Suvi; Mykkänen, Juha; Ahola‐Olli, Ari; Loo, Britt-Marie; Lyytikäinen, Leo-Pekka; Lehtimäki, Terho; Kähönen, Mika; Juonala, Markus; Rönnemaa, Tapani; Lamina, Claudia; Kronenberg, Florian; Viikari, Jorma

doi:10.1016/j.atherosclerosis.2022.07.009

Cited by 9 publications

(8 citation statements)

References 66 publications

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“…We studied 800 individuals aged 49 (44-53) years (68% women), including 17.8% with Lp(a) >50 mg/dl with a higher proportion of females in this subgroup (Table 1). The prevalence of Lp(a) >50 mg/dl was 18.4% in Germany, which is almost identical to our population while in Finland or Greece, it was 6.0% [5,6]. Our result is slightly lower than in the study by Ratajczak et al [3], which evaluated CVD risk factors in subjects aged 18-80 (median, 52 [43-60]) years, while we assessed younger subjects.…”

Section: Resultssupporting

confidence: 65%

Elevated lipoprotein (a) in middle-aged Polish population: preliminary data on genetic background

Konieczyńska,

Nowak,

Pudło

et al. 2023

Kardiol Pol

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Section: Resultssupporting

confidence: 65%

Elevated lipoprotein (a) in middle-aged Polish population: preliminary data on genetic background

Konieczyńska,

Nowak,

Pudło

et al. 2023

Kardiol Pol

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“…No association was found between serum phytosterol levels and Lp(a). This was expected, as the expression of Lp(a) is genetically determined and its levels are stable throughout the lifetime [ 23 ]. This lack of association would have been found had Lp(a) been measured in both follow-ups.…”

Section: Discussionmentioning

confidence: 99%

Association between Serum Phytosterols and Lipid Levels in a Population-Based Study

Stanasila,

Lütjohann,

Popp

et al. 2024

Nutrients

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The association between phytosterols and lipid levels remains poorly assessed at a population level. We assessed the associations between serum levels of six phytosterols (campesterol, campestanol, stigmasterol, sitosterol, sitostanol and brassicasterol) and of lipids [total, low-density lipoprotein (LDL)- and high-density lipoprotein (HDL)-cholesterol, triglycerides, apolipopoprotein A-IV and lipoprotein Lp(a)] in two cross-sectional surveys of a population-based, prospective study. Data from 910 participants (59.1% women, 70.4 ± 4.7 years) for the first survey (2009–2012) and from 721 participants (60.2% women, 75.1 ± 4.7 years) for the second survey (2014–2017) were used. After multivariable adjustment, all phytosterols were positively associated with total cholesterol: slope and (95% confidence interval) 1.594 (1.273–1.915); 0.073 (0.058–0.088); 0.060 (0.044–0.076); 2.333 (1.836–2.830); 0.049 (0.033–0.064) and 0.022 (0.017–0.028) for campesterol, campestanol, stigmasterol, sitosterol, sitostanol and brassicasterol, respectively, in the first survey, and 1.257 (0.965–1.548); 0.066 (0.052–0.079); 0.049 (0.034–0.063); 1.834 (1.382–2.285); 0.043 (0.029–0.057) and 0.018 (0.012–0.023) in the second survey, all p < 0.05. Similar positive associations were found between all phytosterols and LDL cholesterol. Positive associations were found between campesterol and sitosterol and HDL-cholesterol: slope and (95% CI) 0.269 (0.134–0.405) and 0.393 (0.184–0.602) for campesterol and sitosterol, respectively, in the first survey, and 1.301 (0.999–1.604) and 0.588 (0.327–0.849) in the second survey, all p < 0.05. No associations were found between phytosterols and triglyceride or lipoprotein Lp(a) levels, while a positive association between campesterol and apolipoprotein A-IV levels was found: 2.138 (0.454–3.822). Upon normal dietary intakes, serum phytosterol levels were positively associated with total and LDL cholesterol levels, while no consistent association with other lipid markers was found.

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“…Participants were considered having hypertension if they had systolic blood pressure ≥ 140 mmHg, diastolic blood pressure ≥ 90 mmHg or they were under antihypertensive medications 30 . Data on cardiovascular outcomes (N = 45) such as coronary artery disease, peripheral artery disease and atherosclerotic cerebrovascular disease, was obtained from national data registries and the Care Register for Health Care and the National Death Index 31 . Data on lipid-lowering (N = 62) and antihypertensive (N = 163) medication was self-reported while register-based data on diabetes medication (N = 22) was used.…”

Section: Methodsmentioning

confidence: 99%

Determinants of echocardiographic epicardial adipose tissue in a general middle-aged population - The Cardiovascular Risk in Young Finns Study

Gustafsson,

Rovio,

Ruohonen

et al. 2024

Sci Rep

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Epicardial adipose tissue (EAT) is the cardiac visceral fat depot proposed to play a role in the etiology of various cardiovascular disease outcomes. Little is known about EAT determinants in a general population. We examined cardiometabolic, dietary, lifestyle and socioeconomic determinants of echocardiograpghically measured EAT in early adulthood. Data on cardiometabolic, dietary, lifestyle and socioeconomic factors were collected from participants of the Cardiovascular Risk in Young Finns Study (YFS; N = 1667; age 34–49 years). EAT thickness was measured from parasternal long axis echocardiograms. Multivariable regression analysis was used to study potential EAT determinants. Possible effect modification of sex was addressed. Mean EAT thickness was 4.07 mm (95% CI 4.00–4.17). Multivariable analysis [β indicating percentage of change in EAT(mm) per one unit increase in determinant variable] indicated female sex (β = 11.0, P < 0.0001), type 2 diabetes (β = 14.0, P = 0.02), waist circumference (cm) (β = 0.38, P < 0.0001), systolic blood pressure (mmHg) (β = 0.18, P = 0.02) and red meat intake (g/day) (β = 0.02, P = 0.05) as EAT determinants. Sex-specific analysis revealed age (year) (β = 0.59, P = 0.01), alcohol intake (drinks/day) (β = 4.69, P = 0.006), heavy drinking (yes/no) (β = 30.4, P < 0.0001) as EAT determinants in women and fruit intake (g/day) (β = −1.0, P = 0.04) in men. In the YFS cohort, waist circumference, systolic blood pressure and red meat intake were directly associated with EAT among all participants. In women, age, alcohol intake, heavy drinking and type 2 diabetes associated directly with EAT, while an inverse association was observed between fruit intake and EAT in men.

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Long-term tracking and population characteristics of lipoprotein (a) in the Cardiovascular Risk in Young Finns Study

Cited by 9 publications

References 66 publications

Elevated lipoprotein (a) in middle-aged Polish population: preliminary data on genetic background

Elevated lipoprotein (a) in middle-aged Polish population: preliminary data on genetic background

Association between Serum Phytosterols and Lipid Levels in a Population-Based Study

Determinants of echocardiographic epicardial adipose tissue in a general middle-aged population - The Cardiovascular Risk in Young Finns Study

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