Long-term toxicity of the treatment of Hodgkin’s disease

Armitage, Jamés O.

doi:10.1093/annonc/9.suppl_5.s133

Cited by 13 publications

(4 citation statements)

References 25 publications

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“…We found that gender, age, length of time since diagnosis and cancer type affect the frequency and type of health effects experienced by long‐term cancer survivors. Other investigators have noted significant late morbidity in Hodgkin's disease survivors,26 as well as correlations between age and adverse effects 27. We also found a high preponderance of health effects in Hodgkin's disease survivors; despite their young age, they frequently reported heart problems (26.3%), thyroid problems (33.8%), arthritis/osteoporosis problems (14.4%) and lung problems (10%).…”

Section: Discussionsupporting

confidence: 61%

“…Another study reported that 20% of ovarian cancer survivors had abdominal and gynecologic side effects and neurotoxicities 16. Others have reported on late effects in long‐term survivors of Hodgkin's disease including children 17, 18, 19, 20. Overall, the available studies tend to focus on relatively specific health questions, to pertain to individual cancer types and to have fairly brief follow‐up duration.…”

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confidence: 99%

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Health profiles in 5836 long‐term cancer survivors

Schultz

Beck

Stava

et al. 2003

Intl Journal of Cancer

132

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Increasingly, prolonged survival follows the diagnosis of cancer. Cancer therapies result in complex and lasting health effects that create unique health-care needs for the survivors but are poorly understood (especially in survivors of adult cancers). Cancer survivors were asked to respond to a mailed health survey and provide medical and social information pertaining to their cancer experience. Information about demographics and perceived disease-related medical problems was analyzed. We analyzed the response of 5,836 survivors of adult cancers. Two-thirds of the responses came from women, and the response rate was 51% in both sexes. The mean interval since cancer diagnosis was 18.0 ؎ 8.5 years. Younger survivors and men were more likely to report that cancer had affected their health. The health effect most commonly reported by survivors was arthritis/osteoporosis (26% of respondents). Survivors of Hodgkin's disease prominently reported thyroid and lung problems (33.8% of responders with the diagnosis). Prior diagnosis of lymphoma was associated with frequent mention of memory loss (14.7%). The passage of time decreased some perceived effects (memory loss) but increased others (arthritis/osteoporosis, cataracts). Compared with the general population, the incidence of several age-and gender-adjusted health conditions in cancer survivors is different. This group of cancer survivors reported generally good health but outlined multiple lasting medical problems. The health survey described represents 1 approach to the development of comprehensive information about the health needs of cancer survivors.

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Section: Discussionsupporting

confidence: 61%

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confidence: 99%

Health profiles in 5836 long‐term cancer survivors

Schultz

Beck

Stava

et al. 2003

Intl Journal of Cancer

132

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“…Second malignant neoplasms affect up to 10% of these patients [11,48]. In addition to these potentially fatal late complications, these patients have to face delayed adverse effects of therapy on the thyroid, reproductive system, and skeleton [8].…”

Section: Hodgkin's Diseasementioning

confidence: 99%

Psychosocial rehabilitation of cancer patients after curative therapy

Ronson

Body

2001

Support Care Cancer

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The concept of rehabilitation of cancer patients is based on the relatively recent awareness of the strong interrelations existing between physical, psychological and social aspects of human life. Cancer potentially disrupts all of these primary components of quality of life. The aim of rehabilitation is to promote global physical and psychosocial adjustment by acting at all modifiable levels, namely strengthening individual coping resources through psychotherapy, improving quantity and quality of familial and social support, and restoring optimal physical functioning.

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“…1,2,5,13 Hodgkin lymphoma (HL) treatment historically entailed high-intensity irradiation and chemotherapy, which has resulted in diverse long-term complications. 14,15 DHS is seen in HL survivors up to 4 decades after mantle field irradiation, [16][17][18][19][20][21][22][23] which can damage neurological and muscular structures adjacent to lymph nodes of the axillae, chest, and neck. 24 Leydig cell damage is a complication in male HL survivors who have undergone chemotherapy with alkylating agents (eg, cyclophosphamide and procarbazine).…”

Section: Introductionmentioning

confidence: 99%

Testosterone Therapy for Dropped Head Syndrome: A Case Report

Felong

Balos

Silvestri

2022

Journal of Clinical Neuromuscular Disease

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Dropped head syndrome (DHS) is an impairment of neck extension resulting in a chin-on-chest deformity. DHS is rarely seen but a major hindrance to daily function in affected patients. DHS has been associated with movement disorders, neuromuscular disorders, and electrolyte and endocrine abnormalities. DHS has also been seen in survivors of Hodgkin lymphoma (HL) years after irradiation. HL survivors are also at risk for endocrine hypogonadism after chemotherapy. We present the case of a 58-year-old male HL survivor with dropped head and limited strength in his atrophic neck extensor muscles. Laboratory testing and imaging, nerve conduction studies, electromyography, and muscle biopsy of the neck extensors revealed myopathic and neurogenic changes. Conservative management was unsuccessful. With a desire to avoid surgical fixation, he asked his primary care physician to check his testosterone levels, which returned as low normal. Within 4 months of starting testosterone therapy, he no longer experienced dropped head.

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Long-term toxicity of the treatment of Hodgkin’s disease

Cited by 13 publications

References 25 publications

Health profiles in 5836 long‐term cancer survivors

Health profiles in 5836 long‐term cancer survivors

Psychosocial rehabilitation of cancer patients after curative therapy

Testosterone Therapy for Dropped Head Syndrome: A Case Report

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