Long-Term Toxic Effects, Swallow Function, and Quality of Life on MC1273: A Phase 2 Study of Dose De-escalation for Adjuvant Chemoradiation in Human Papillomavirus-Positive Oropharyngeal Cancer

Price, Katharine A.; Abel, Kathryn M. Van; Moore, Eric J.; Patel, Samir H.; Hinni, Michael L.; Chintakuntlawar, Ashish V.; Graner, Darlene E.; SLP.D, M. Neben-Wittich; Garces, Yolanda I.; Price, Daniel L.; Janus, Jeffrey R.; Foster, Nathan R.; Ginos, Brenda; Foote, Robert L.; Ma, Daniel

doi:10.1016/j.ijrobp.2022.05.047

Cited by 3 publications

(4 citation statements)

References 31 publications

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“…According to the study design, 10 articles were prospective study designs (55.6%) [ 14 – 16 , 18 , 21 , 22 , 24 , 28 – 30 ] while seven were retrospective studies [ 13 , 17 , 20 , 23 , 25 – 27 ]. One study was based on a prospective case series [ 19 ].…”

Section: Resultsmentioning

confidence: 99%

“…Although some studies demonstrated no significant difference between the cohorts [ 24 , 26 , 28 ], most of the evaluated studies demonstrated a shorter recovery time to reach baseline or better QOL in patients who underwent TORS. The deterioration in QOL in the presence of adjuvant therapy is also worth noting in decision-making on the suitable treatment option.…”

Section: Discussionmentioning

confidence: 99%

“…Additionally, the comparison group in most of the included studies underwent adjuvant therapy under various management protocols, and this could have significantly affected the post-operative QOL they reported [ 17 , 18 , 22 ]. Varying survey time points [ 13 , 15 , 17 , 22 , 29 ], lack of pre-operative QOL data [ 13 , 27 , 28 ] and lack of long-term follow up [ 21 ] were also mentioned as possible limitations in the included studies.…”

Section: Discussionmentioning

confidence: 99%

“…A majority of the patients tolerated total oral intake without restrictions Patients with oropharyngeal squamous cell carcinoma treated with neoadjuvant chemotherapy and TORS may achieve favourable long-term swallowing outcomes, by preventing post-operative radiotherapy. Nevertheless, the pre-treatment MDADI scores were not available to detect the precision changes in the swallowing function 16 Price et al (2022) [ 28 ] USA (System not mentioned) Prospective cohort study 79 patients (71 males [89.9%] and 8 females) with Oropharyngeal CA. All underwent surgery (94.9% TORS) with adjuvant CRT under two different regimes.…”

Section: Methodsmentioning

confidence: 99%

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Quality of life of patients treated with robotic surgery in the oral and maxillofacial region: a scoping review of empirical evidence

Bandara,

Kanmodi,

Salami

et al. 2024

BMC Oral Health

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Background There is a blooming trend in the application of robotic surgery in oral and maxillofacial care, and different studies had evaluated the quality of life (QoL) outcomes among patients who underwent robotic surgery in the oral and maxillofacial region. However, empirical evidence on the QoL outcomes from these procedures is yet to be mapped. Thus, this study was conducted to evaluate the available scientific evidence and gaps concerning the QoL outcomes of patients treated with robotic surgery in the oral and maxillofacial region. Methods This study adopted a scoping review design, and it was conducted and reported based on the Arksey and O’Malley, PRISMA-ScR, and AMSTAR-2 guidelines. SCOPUS, PubMed, CINAHL Complete, and APA PsycINFO were searched to retrieve relevant literature. Using Rayyan software, the retrieved literature were deduplicated, and screened based on the review’s eligibility criteria. Only the eligible articles were included in the review. From the included articles, relevant data were charted, collated, and summarized. Results A total of 123 literature were retrieved from the literature search. After deduplication and screening, only 18 heterogeneous original articles were included in the review. A total of 771 transoral robotic surgeries (TORSs) were reported in these articles, and the TORSs were conducted on patients with oropharyngeal carcinomas (OPC), recurrent tonsillitis, and obstructive sleep apnoea (OSA). In total, 20 different QoL instruments were used in these articles to assess patients’ QoL outcomes, and the most used instrument was the MD Anderson Dysphagia Inventory Questionnaire (MDADI). Physical functions related to swallowing, speech and salivary functions were the most assessed QoL aspects. TORS was reported to result in improved QOL in patients with OPC, OSA, and recurrent tonsillitis, most significantly within the first postoperative year. Notably, the site of the lesion, involvement of neck dissections and the characteristics of the adjuvant therapy seemed to affect the QOL outcome in patients with OPC. Conclusion Compared to the conventional treatment modalities, TORS has demonstrated better QoL, mostly in the domains related to oral functions such as swallowing and speech, among patients treated with such. This improvement was most evident within the initial post-operative year.

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