Long Term Tirofiban Infusion Before Pci in Patients With Angiographically Massive Intracoronary Thrombus

Timurkaynak, Timur; Arslan, Ümit; Balcıoğlu, Serhat; Kocaman, S.A.; Türkoğlu, Suna

doi:10.1016/s1567-5688(08)70838-9

Cited by 4 publications

(6 citation statements)

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“…It enhanced epicardial reperfusion rate of fibrinolytics and also improved the flow rate in the infarct-related arteries treated with stent implantation [5][6][7]. Moreover, some medical literatures that has been published recently also propose that tirofiban could dissolve massive intracoronary thrombus [1,8,9]. We also observed a similar effect of tirofiban in both of our cases.…”

supporting

confidence: 79%

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Position of tirofiban in ST segment elevation myocardial infarction treatment

Karabulut

Cakmak

2011

Blood Coagulation & Fibrinolysis

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supporting

confidence: 79%

“…Most of the cardiac centers use fibrinolytics or glycoprotein IIb/IIIa inhibitors in single or combined form. Usage and efficacy of tirofiban in failed primary PCI patient were reported only in selective cases [8][9][10]. There has not been any comprehensive data reported about tirofiban usage in failed primary PCI reported before.…”

mentioning

confidence: 99%

Position of tirofiban in ST segment elevation myocardial infarction treatment

Karabulut

Cakmak

2011

Blood Coagulation & Fibrinolysis

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“…2 Two methods used to prevent the occurrence of no/slow reflow after PCI are the application of enhanced thrombus removal devices and anticoagulant antiplatelet therapy. 3 A higher incidence of bleeding is associated with methods that use low-molecular weight heparin or triple antiplatelet therapy, both of which can increase mortality rates during hospitalization. 4 Thrombus aspiration during emergency PCI can improve the myocardial reperfusion index and prognosis in patients with acute ST-segment elevation during MI.…”

Section: Introductionmentioning

confidence: 99%

Clinical evaluation of thrombus aspiration combined with tirofiban in patients with acute myocardial infarction with elective percutaneous coronary intervention

et al. 2013

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Objective: To compare the efficacy and safety of combined treatment with thrombus aspiration and intracoronary tirofiban in patients with acute myocardial infarction (MI), with elective percutaneous coronary intervention (PCI). Methods: Patients undergoing elective PCI during recovery from acute MI were randomized into two groups; the intervention group received thrombus aspiration and intracoronary tirofiban; the control group received conventional PCI. Baseline clinical characteristics, postoperative coronary blood flow (thrombolysis in myocardial infarction [TIMI] grade), TIMI myocardial perfusion (TMP) grade, no/slow reflow rate and cardiac function (measured by echocardiography 1 month postoperatively) were evaluated. Major adverse cardiac event rate and bleeding complications during surgery (and at 1 month and 1 year postoperatively) were also evaluated. Results: A total of 80 patients were included. Postoperatively, the number of patients with TIMI flow grade 3 and the mean TMP grade were both significantly higher, and the no/slow reflow rate was significantly lower, in the intervention group versus the control group. Echocardiography indicated that cardiac function was significantly improved in the intervention group compared with the control group. There were no major complications in either study group. Conclusion: Thrombus aspiration combined with intracoronary tirofiban during recovery from acute MI was effective and relatively well tolerated.

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“…The contribution of GP IIb/IIIa inhibitor therapy on clot dissolution remains unclear, but it was thought to have a beneficial effect on coronary clot dissolution. GP IIb/IIIa inhibitors can be helpful for dissolving coronary thrombus by assisting spontaneous fibrinolysis 20 21…”

Section: Discussionmentioning

confidence: 99%

Acute inferior myocardial infarction in a young male patient associated with Behcet's disease and sildenafil

et al. 2014

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Behcet's disease (BD) is a multisystemic inflammatory disorder of unknown origin, presenting with mucocutaneous, ocular, articular, vascular, gastrointestinal and central nervous system manifestations. Coronary involvement is very rare in patients with BD. Sildenafil, an oral drug used to treat erectile dysfunction, was shown to cause significant cardiovascular problems including acute myocardial infarction (MI) and sudden cardiac death. Acute MI associated with BD and sildenafil has not been reported previously. We present a case of a 23-year-old male patient with an acute inferior MI associated with BD diagnosed after admission of sildenafil, who was successfully treated with thrombus aspiration and tirofiban administration.

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Long Term Tirofiban Infusion Before Pci in Patients With Angiographically Massive Intracoronary Thrombus

Cited by 4 publications

References 0 publications

Position of tirofiban in ST segment elevation myocardial infarction treatment

Position of tirofiban in ST segment elevation myocardial infarction treatment

Clinical evaluation of thrombus aspiration combined with tirofiban in patients with acute myocardial infarction with elective percutaneous coronary intervention

Acute inferior myocardial infarction in a young male patient associated with Behcet's disease and sildenafil

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