Long-Term Therapy of Acne with Tetracycline

Cornbleet, Theodore

doi:10.1001/archderm.1961.01580090064006

Cited by 9 publications

(6 citation statements)

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“…There are over 1000 reports of effective treatment for acne; unfortunately many papers are of little scientific value because of the lack of adequate objective assessment of acne and placebo groups. AH except two (Cornbleet, 1961;Gould & Cunliffe, 1978) relate to the treatment of acne for 2 or 3 months with no follow-up. Clinical experience dictates that acne often requires treatment for many months or even years and highlights an important gap in the published literature regarding the long-term management of acne.…”

Section: Review Of Existing Treatment For Acnementioning

confidence: 99%

Acne vulgaris-its aetiology and treatment. A review*

et al. 1981

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Acne vulgaris is so common that it can almost be regarded as a physiological phenomenon of adolescence. However, up to 30",, of teenagers develop acne of such severity to require treatment from their general practitioner or dermatologist. Acne is rarely life-threatening, but its cosmetic effects often produce social problems in the home, at school and at work, which in extreme cases has led to suicide.In order to appreciate the reasoning behind the treatment for acne it is first necessary to review its aetiology and pathogenesis. Aetiology and pathogenesis of acneAcne affects the face and less frequently the back and chest. These are the sites of maximum density of sebaceous glands and there is a high correlation between the amount of sebum produced (on the forehead) and the severity of acne (on the face) (Cunhffe & Shuster, 1969a). The precise biochemical control of sebum production is uncertain. Some acne patients have increased levels of circulating plasma androgens (Forstrom et al.y 1974;Lim & James, 1974) but the most likely explanation for acne is that the sebaceous glands over-respond to 'normal' amounts of circulating androgens (possibly on a genetic basis).If an increased sebum production were solely responsible for acne, then we might expect sebum production to decrease as acne resolves. By the age of 25 years, acne has remitted in most males and 95",, of females, but sebum production still remains high compared with age-matched non-acne subjects (Cunliffe & Shuster, 1969a).

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Section: Review Of Existing Treatment For Acnementioning

confidence: 99%

Acne vulgaris-its aetiology and treatment. A review*

et al. 1981

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“…This may not necessarily reflect that patients with acne are treated badly but the lack of knowledge on this problem suggests that long-term therapy could possibly be improved. The only other published long-term study (Cornbleet, 1961) indicated the beneficial effect of tetracycline over a period of t2 months in most patients; the same study also indicated that in 6",, of patients tetracychne therapy was of no value whatsoever.…”

Section: Discussionmentioning

confidence: 93%

“…Most trials have been involved with a single therapy rather than the combined use of topical and oral preparations (Michaelsson, Juhlin & Vahlquist, 1977) which are often used in clinical practice. In addition, there are few long-term studies (Cornbleet, 1961) indicating the overall effectiveness or otherwise, of treatment given to patients with acne vulgaris. We have, therefore, reviewed 57 patients whom we have followed for 12 months in a routine dermatological clinic.…”

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confidence: 99%

The long-term treatment of acne vulgaris

Gould

Cunliffe

1978

Clin Exp Dermatol

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Summary A clinical investigation of 57 patients with moderate acne indicated that the response to treatment with long‐term antibiotics and appropriate topical therapy could be divided into three groups. One group of patients (28%) showed an 80% improvement within 4 months of starting treatment. In 37% such an improvement took 12 months and in a third group (35%) only a 57% improvement was obtained at the end of 12 months. There was no obvious clinical reason for these three responsive groups.

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“…Crounse [226] failed to obtain better results with tetracycline than with placebo in a crossover study in acne nurses. Cornbleet [227] brought evidence of the beneficial effects of tetracycline even in doses much lower than those usually used against infectious diseases. Baer and Witten [228] observed that many nonpustular forms of acne responded to antibacterial treatment.…”

Section: From Acne Microbacillus To P Acnes: Facts Controversies Anmentioning

confidence: 99%

“…Baer and Witten [228] observed that many nonpustular forms of acne responded to antibacterial treatment. Furthermore, as Cornbleet [227], they pointed out the fact that in some patients acne could be suppressed with doses which might be regarded as insufficient for bacteriostatic or bactericidal action. They proposed that antibiotics may act not on the microorganisms in the acne lesions but on those in the intestinal tract and that modes of action other than antibacterial had to be considered [228].…”

Section: From Acne Microbacillus To P Acnes: Facts Controversies Anmentioning

confidence: 99%

Acne Pathogenesis: History of Concepts

Tilles¹

2014

Dermatology

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From the first reliable descriptions of acne in the early 19th century, dermatologists recognized it as a disease of the pilosebaceous follicle. Until the middle of the 20th century, they hypothesized that seborrhoea, follicular keratosis and microorganisms could be individually responsible for the acne lesions. Inflammation was only regarded as the final and inescapable step of the acne process. Although the importance of these factors has been reevaluated, recent works still regarded them as mandatory. In the 1970s, the onset of isotretinoin dramatically improved acne management. It also provided great opportunities for a better understanding of the pathogenic factors of acne. This study analyzes their genesis and development from the seminal contributions until recent advances.

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Long-Term Therapy of Acne with Tetracycline

Cited by 9 publications

References 0 publications

Acne vulgaris-its aetiology and treatment. A review*

Acne vulgaris-its aetiology and treatment. A review*

The long-term treatment of acne vulgaris

Acne Pathogenesis: History of Concepts

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