Long-term Therapeutic Effect of M3 Muscarinic Acetylcholine Receptor Agonists in Patients with Sjögren’s Syndrome

Sakamoto, M.; Moriyama, Masafumi; Shimizu, Masakata; Mitsui, Takashi; Ogata, Kenichi; Ishiguro, Nozomu; Chinju, Akira; Ohta, Miho; Nakamura, Seiji

doi:10.6014/jjsom.26.77

Cited by 1 publication

(1 citation statement)

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“…Hence, a good indication for pilocarpine hydrochloride administration would be cases with a Schirmer 1 test value of 5 mm or more, in which there is some degree of preserved lacrimal gland function. Sakamoto et al [ 45 ] reported that salivary secretion was maintained after 8 years with the long-term oral administration of M3R agonists, and multivariate analysis showed a significant rate of increase in salivary secretion in patients with preserved salivary function or without severe tissue abnormalities at the initial visit. Those findings suggest that when lacrimal and salivary gland function is preserved, the early initiation and continuation of oral M3R agonists such as pilocarpine is important to maintain quality of life in patients with SS.…”

Section: Discussionmentioning

confidence: 99%

Effectiveness of Single-Dose Oral Pilocarpine Administration in Patients with Sjögren’s Syndrome

Komuro,

Yokoi,

Sotozono

et al. 2023

Diagnostics

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In this study, we evaluated the effectiveness of a single-dose oral pilocarpine administration on tear film (TF), as well as dry eye and dry mouth symptoms, in 53 eyes of 27 Sjögren syndrome (SS) patients who were experiencing dry mouth. To evaluate the changes in tear volume, a digital video-meniscometer was used to measure the radius of the lower central tear meniscus curvature (R, mm) of each eye at prior to the administration of 5 mg oral pilocarpine, and at 15 (R:(15)), 30 (R:(30)), and 60 (R:(60)) minutes after administration. The fluorescein breakup time (FBUT, seconds) and ocular and oral dryness symptoms were evaluated before and at 60 min after administration using a visual analogue scale (VAS, mm). A significant increase in R was observed at 15 and 30 min after administration compared to that at prior to administration. FBUT showed significant improvement at 60 min after administration, and the VAS score for ocular and oral dryness symptoms was found to have decreased significantly at 60 min after administration. A single-dose administration of 5 mg oral pilocarpine had a beneficial effect on TF, as well as on ocular and oral dryness symptoms, in patients with SS.

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Section: Discussionmentioning

confidence: 99%