Long-term taurine administration improves motor skills in a tubulinopathy rat model by decreasing oxidative stress and promoting myelination

Vargas-Castro, Viridiana; Gomez-Diaz, Ricardo; Blanco-Álvarez, Víctor Manuel; Tomás-Sanchez, Constantino; Gonzalez-Vazquez, Alejandro; Aguilar-Peralta, Ana Karina; González-Barrios, Juan Antonio; Martínez‐Fong, Daniel; Eguíbar, José Ramón; Vivar, Carmen; Ugarte, Araceli; Soto-Rodríguez, Guadalupe; Brambila, Eduardo; Millán-Pérez-Peña, Lourdes; León-Chávez, Bertha Alicia

doi:10.1016/j.mcn.2021.103643

Cited by 7 publications

(4 citation statements)

References 71 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Taurine improves innate motor behaviors such as cliff aversion, grip strength, and forelimb suspension with respect to untreated taiep rats. Taurine is also capable of significantly decreasing the number of immobility episodes induced by gripping the tail of adult taiep rats [57]. These results also show that early intervention with taurine could change the progression of myelination in taiep rats.…”

Section: Plos Onementioning

confidence: 52%

“…Recently, we showed that the long-term administration of 50 mg/L of taurine (2-aminoethanesulfonic acid) in drinking water from gestational age 15 to postnatal day 240 decreases nitrites and lipoperoxidation in the central nervous system in adult male taiep rats and this amino acid increases cell proliferation in the dentate gyrus and in the pons in our tubulinopathy rat model [57]. Taurine improves innate motor behaviors such as cliff aversion, grip strength, and forelimb suspension with respect to untreated taiep rats.…”

Section: Plos Onementioning

confidence: 86%

See 1 more Smart Citation

4-aminopyridine improves evoked potentials and ambulation in the taiep rat: A model of hypomyelination with atrophy of basal ganglia and cerebellum

Eguibar,

Cortes,

Hernandez

et al. 2024

PLoS ONE

Self Cite

View full text Add to dashboard Cite

The taiep rat is a tubulin mutant with an early hypomyelination followed by progressive demyelination of the central nervous system due to a point mutation in the Tubb4a gene. It shows clinical, radiological, and pathological signs like those of the human leukodystrophy hypomyelination with atrophy of the basal ganglia and cerebellum (H-ABC). Taiep rats had tremor, ataxia, immobility episodes, epilepsy, and paralysis; the acronym of these signs given the name to this autosomal recessive trait. The aim of this study was to analyze the characteristics of somatosensory evoked potentials (SSEPs) and motor evoked potentials (MEPs) in adult taiep rats and in a patient suffering from H-ABC. Additionally, we evaluated the effects of 4-aminopyridine (4-AP) on sensory responses and locomotion and finally, we compared myelin loss in the spinal cord of adult taiep and wild type (WT) rats using immunostaining. Our results showed delayed SSEPs in the upper and the absence of them in the lower extremities in a human patient. In taiep rats SSEPs had a delayed second negative evoked responses and were more susceptible to delayed responses with iterative stimulation with respect to WT. MEPs were produced by bipolar stimulation of the primary motor cortex generating a direct wave in WT rats followed by several indirect waves, but taiep rats had fused MEPs. Importantly, taiep SSEPs improved after systemic administration of 4-AP, a potassium channel blocker, and this drug induced an increase in the horizontal displacement measured in a novelty-induced locomotor test. In taiep subjects have a significant decrease in the immunostaining of myelin in the anterior and ventral funiculi of the lumbar spinal cord with respect to WT rats. In conclusion, evoked potentials are useful to evaluate myelin alterations in a leukodystrophy, which improved after systemic administration of 4-AP. Our results have a translational value because our findings have implications in future medical trials for H-ABC patients or with other leukodystrophies.

show abstract

Section: Plos Onementioning

confidence: 52%

Section: Plos Onementioning

confidence: 86%

4-aminopyridine improves evoked potentials and ambulation in the taiep rat: A model of hypomyelination with atrophy of basal ganglia and cerebellum

Eguibar,

Cortes,

Hernandez

et al. 2024

PLoS ONE

Self Cite

View full text Add to dashboard Cite

show abstract

“…The evaluator's average speed for manipulating the mesh should be a five-degree inclination per 2 s of testing. The test was repeated three times for each pup, and the average value was used to determine the mean ± SEM of at least 7 pups per group [ 3 , 5 ].…”

Section: Experimental Design Materials and Methodsmentioning

confidence: 99%

“…Therefore, the present datasets can be valuable for researchers who attempt to use the taurine supplement on healthy animal models at gestational stages; and explore the relation with taurine intake during pregnancy in human patients. These datasets are related to the article “Long-term taurine administration improves motor skills in a tubulinopathy rat model by decreasing oxidative stress and promoting myelination” [5] .…”

mentioning

confidence: 99%

Effects of chronic taurine administration on healthy pregnant rats and the consequences on the offspring: Datasets for motor tests and oxidative stress

et al. 2022

Self Cite

View full text Add to dashboard Cite

Neuroprotection elicited by taurine in sporadic Alzheimer-like disease: benefits on memory and control of neuroinflammation in the hippocampus of rats

Huf,

Gutierres,

da Silva

et al. 2023

Mol Cell Biochem

View full text Add to dashboard Cite

Long-term taurine administration improves motor skills in a tubulinopathy rat model by decreasing oxidative stress and promoting myelination

Cited by 7 publications

References 71 publications

4-aminopyridine improves evoked potentials and ambulation in the taiep rat: A model of hypomyelination with atrophy of basal ganglia and cerebellum

4-aminopyridine improves evoked potentials and ambulation in the taiep rat: A model of hypomyelination with atrophy of basal ganglia and cerebellum

Effects of chronic taurine administration on healthy pregnant rats and the consequences on the offspring: Datasets for motor tests and oxidative stress

Neuroprotection elicited by taurine in sporadic Alzheimer-like disease: benefits on memory and control of neuroinflammation in the hippocampus of rats

Contact Info

Product

Resources

About