Long-term T2 and Qualitative MRI Morphology After First-Generation Knee Autologous Chondrocyte Implantation

Salzmann, Gian M.; Erdle, Benjamin; Porichis, Stella; Uhl, Markus; Ghanem, Nadir; Schmal, Hagen; Kubosch, David; Südkamp, Norbert P.; Niemeyer, Philipp

doi:10.1177/0363546514536682

Cited by 45 publications

(61 citation statements)

References 42 publications

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“…Following microfracture for cartilage defects, Domayer et al reported the T 2 mapping value of the repair tissue is directly correlated with the Lysholm patient‐reported outcome score. A similar finding has been reported after both autologous chondrocyte implantation and matrix‐associated chondrocyte implantation, with the T2 values inversely correlated with the Lysholm score . Tadenuma et al found a strong correlation between dGEMRIC values of cartilage with the Lysholm score at a mean of 5.9 years after cartilage restoration.…”

Section: Pre‐structural Imagingsupporting

confidence: 72%

“…17 T 2 mapping and dGEMRIC have been most frequently studied in this capacity to date. [18][19][20][21][22] The advanced imaging measurements correlate with both arthroscopic findings at the time of surgical treatment of knee conditions and with patient results after treatment, reflecting the potential importance of these measurements in both diagnosis and objective evaluation of treatment outcomes. The routine addition of T 2 mapping to clinical sequences can improve the sensitivity and specificity for detection of cartilage injuries in the knee, highlighting both the feasibility of this method and the potential added benefit of acquiring this sequence.…”

Section: Cartilage Imagingmentioning

confidence: 93%

“…A similar finding has been reported after both autologous chondrocyte implantation and matrix-associated chondrocyte implantation, with the T2 values inversely correlated with the Lysholm score. 21,22 Tadenuma et al 20 found a strong correlation between dGEMRIC values of cartilage with the Lysholm score at a mean of 5.9 years after cartilage restoration.…”

Section: Cartilage Imagingmentioning

confidence: 99%

“…Measurements from multiple different quantitative MR sequences also correlate with clinical outcomes after cartilage repair surgery . T 2 mapping and dGEMRIC have been most frequently studied in this capacity to date . The advanced imaging measurements correlate with both arthroscopic findings at the time of surgical treatment of knee conditions and with patient results after treatment, reflecting the potential importance of these measurements in both diagnosis and objective evaluation of treatment outcomes.…”

Section: Pre‐structural Imagingmentioning

confidence: 99%

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Clinical Utility of Advanced Imaging of the Knee

Lansdown

Benjamin

2019

Journal Orthopaedic Research

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Advanced imaging modalities, including computed tomography, magnetic resonance imaging (MRI), and dynamic fluoroscopic imaging, allow for a comprehensive evaluation of the knee joint. Compositional sequences for MRI can allow for an evaluation of the biochemical properties of cartilage, meniscus, and ligament that offer further insight into pathology that may not be apparent on conventional clinical imaging. Advances in image processing, shape modeling, and dynamic studies also offer a novel way to evaluate common conditions and to monitor patients after treatment. The purpose of this article is to review advanced imaging modalities of the knee and their current and anticipated future applications to clinical practice. © 2019 Orthopaedic Research Society. Published by Wiley Periodicals, Inc. J Orthop Res 38:473–482, 2020

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Section: Pre‐structural Imagingsupporting

confidence: 72%

Section: Cartilage Imagingmentioning

confidence: 93%

Section: Cartilage Imagingmentioning

confidence: 99%

Section: Pre‐structural Imagingmentioning

confidence: 99%

See 2 more Smart Citations

Clinical Utility of Advanced Imaging of the Knee

Lansdown

Benjamin

2019

Journal Orthopaedic Research

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“…However, MRI morphology often does not correlate with the clinical outcome after cartilage repair surgery. It could also be that specific parameters that correlate best can vary according to the type of procedure performed [108,109]. …”

Section: Discussionmentioning

confidence: 99%

Osteoarthritis in the Knee Joints of Göttingen Minipigs after Resection of the Anterior Cruciate Ligament? Missing Correlation of MRI, Gene and Protein Expression with Histological Scoring

et al. 2016

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IntroductionThe Göttingen Minipig (GM) is used as large animal model in articular cartilage research. The aim of the study was to introduce osteoarthritis (OA) in the GM by resecting the anterior cruciate ligament (ACLR) according to Pond and Nuki, verified by histological and magnetic resonance imaging (MRI) scoring as well as analysis of gene and protein expression.Materials and MethodsThe eight included skeletally mature female GM were assessed after ACLR in the left and a sham operation in the right knee, which served as control. 26 weeks after surgery the knee joints were scanned using a 3-Tesla high-field MR tomography unit with a 3 T CP Large Flex Coil. Standard proton-density weighted fat saturated sequences in coronal and sagittal direction with a slice thickness of 3 mm were used. The MRI scans were assessed by two radiologists according to a modified WORMS-score, the X-rays of the knee joints by two evaluators. Osteochondral plugs with a diameter of 4mm were taken for histological examination from either the main loading zone or the macroscopic most degenerated parts of the tibia plateau or condyle respectively. The histological sections were blinded and scored by three experts according to Little et al. Gene expression analysis was performed from surrounding cartilage. Expression of adamts4, adamts5, acan, col1A1, col2, il-1ß, mmp1, mmp3, mmp13, vegf was determined by qRT-PCR. Immunohistochemical staining (IH) of Col I and II was performed. IH was scored using a 4 point grading (0—no staining; 3-intense staining).Results and DiscussionSimilar signs of OA were evident both in ACLR and sham operated knee joints with the histological scoring result of the ACLR joints with 6.48 ± 5.67 points and the sham joints with 6.86 ± 5.84 points (p = 0.7953) The MRI scoring yielded 0.34 ± 0.89 points for the ACLR and 0.03 ± 0.17 for the sham knee joints. There was no correlation between the histological and MRI scores (r = 0.10021). The gene expression profiles as well as the immunohistochemical findings showed no significant differences between ACLR and sham knee joints. In conclusion, both knee joints showed histological signs of OA after 26 weeks irrespective of whether the ACL was resected or not. As MRI results did not match the histological findings, MRI was obviously unsuitable to diagnose the OA in GM. The analysis of the expression patterns of the 10 genes could not shed light on the question, whether sham operation also induced cartilage erosion or if the degeneration was spontaneous. The modified Pond-Nuki model may be used with reservation in the adult minipig to induce an isolated osteoarthritis.

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3DMRI Modeling of Thin and Spatially Complex Soft Tissue Structures without Shrinkage: Lamprey Myosepta as an Example

Wood

Jia

Carmichael

et al. 2018

The Anatomical Record

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3D imaging techniques enable the nondestructive analysis and modeling of complex structures. Among these, MRI exhibits good soft tissue contrast, but is currently less commonly used for nonclinical research than X-ray CT, even though the latter requires contrast-staining that shrinks and distorts soft tissues. When the objective is the creation of a realistic and complete 3D model of soft tissue structures, MRI data are more demanding to acquire and visualize and require extensive post-processing because they comprise noncubic voxels with dimensions that represent a trade-off between tissue contrast and image resolution. Therefore, thin soft tissue structures with complex spatial configurations are not always visible in a single MRI dataset, so that standard segmentation techniques are not sufficient for their complete visualization. By using the example of the thin and spatially complex connective tissue myosepta in lampreys, we developed a workflow protocol for the selection of the appropriate parameters for the acquisition of MRI data and for the visualization and 3D modeling of soft tissue structures. This protocol includes a novel recursive segmentation technique for supplementing missing data in one dataset with data from another dataset to produce realistic and complete 3D models. Such 3D models are needed for the modeling of dynamic processes, such as the biomechanics of fish locomotion. However, our methodology is applicable to the visualization of any thin soft tissue structures with complex spatial configurations, such as fasciae, aponeuroses, and small blood vessels and nerves, for clinical research and the further exploration of tensegrity. Anat Rec, 301:1745-1763, 2018. © 2018 Wiley Periodicals, Inc.

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Long-term T2 and Qualitative MRI Morphology After First-Generation Knee Autologous Chondrocyte Implantation

Abstract: The MRI outcome is imperfect in this collective of patients. There is only weak correlation of quantitative imaging data and clinical function. Qualitative imaging data are much better correlated to functional outcomes.

Cited by 45 publications

References 42 publications

Clinical Utility of Advanced Imaging of the Knee

Clinical Utility of Advanced Imaging of the Knee

Osteoarthritis in the Knee Joints of Göttingen Minipigs after Resection of the Anterior Cruciate Ligament? Missing Correlation of MRI, Gene and Protein Expression with Histological Scoring

3DMRI Modeling of Thin and Spatially Complex Soft Tissue Structures without Shrinkage: Lamprey Myosepta as an Example

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